“When you take a breath in...” *takes deep breath automatically, oddly proud of my lungs for doing such a great job*

Thanks so much for taking the time to post this. I have a layman interest in virology which is to say I don't have a medical background but to have viral interaction with body cells explained so clearly is really interesting especially in explaining why fluid in the lungs is generated and the mechanics behind that. I had no idea it was breakdown of the blood vessels and leaking plasma. Thank you, especially as I grew up hearing old folks in my Welsh village speak about fluid on the lungs and too much coughing leading to scaring. Until your post I didn't understand what was behind this.

The simpler way you explain the pathophysiology is fantastic. Anybody can understand. Thank you.

Brilliant!!! I'm an RRT boning up on ARDS, and this is the most informative video i've found yet!

this guy explained it so well. haven't been this interested in a science lesson in a long time

Thank you Doc for the wonderful lecture. Well, that explains why we as healthcare professionals should not sedate heavily or paralyze these COVID pts. Because when you sedate a vented patient, the blood pressure drops. And the traditional response is give more fluids. And the result is a viscous cycle of sedate, bp drops, then more fluids given and those fluids will go to the lungs. Thus needing more peep and oxygen requirements. As a respiratory therapist, we need to find the happy medium of ventilator settings and some sedation just to keep them comfortable. Thank you.

One of the best COVID tutorials I've seen!

Hi Dr. Mike! Thank you, this is the best coronavirus video so far. I’ve been watching your videos for my A&P class, you make it so easy to understand. You helped me a lot 😀

I was waiting for macrophages to come in earlier but the scenario didn’t go as I planned in my head! You’re explaining in such a great way that I remember the joy of studying when I was studying biology in university. Thank you :)

I love people like you sharing important information for free

Thanks for explaining it the way you did! Great video

A Big THANK YOU for making this video, it was asked in my VIVA examination.

Incredible! Thank you for this explanation. You inspired me

Thanks Doc Mike.. wonderful lecture..Now I understand the concepts very well..You are a great teacher ☺️👍🏻

sir, that was mind-blowing. tomorrow i have an exam, and this helped me much♥️

Awesome description, great understanding about pathophysiology of COVID 19

Excellent. Thank you. Clear and concise.

Superb presentation... well done

Ngl I originally clicked because I thought you were shirtless in the thumbnail and I was intrigued by the thought of chaotic science man, but then I stayed for the engaging and informative presentation and overall I was absolutely not disappointed

It would help plenty to have links to research articles in the description or in the comment section, as references or for further reading

you explained it amazingly, thank you so much for all the effort, you are helping a lot of students.

well done doctor💜

Great explanation! Thanks from NZ

Thanks doc...great explanations

Awesome video, been trying to get my head around the whole coronavirus thing and watching this video really helped clear the gaps and understand it so much better. Great explanation cheers!

Hey! Just wanted to say I was watching your videos when I was reviewing for the licensure exams, and now i’m a registered medical lab scientist! So great to have watched this, as always, so easy to follow 😊

What does your fitness routine look like? You get a gold star for health good sir!

Outstanding presentation!

Great teaching!

wow, your explanation on what surfactant does was really helpful, finally get it now thank you heaps

Great explanation. Cheers!

Amazing video. Appreciate the time and effort!

Thanks for the video ! Ur a genius for simplifyiing medicine in sucha manner !

saving me minutes before my pathology exam

this is excellent. Great job

he's so quirky and cute. like the awkward moment at the start and end where he just smiles lol

Thanks a lot, Doc!

Good explanation, thank you.

Pathophysiology: I learned a new word.

Great Information Thanks

Beautifully explained!

Thank you. Your video is very helpful and it's also easy to understand.

Very helpful.. Thank you so much!

u are the best,sir

Very good, clear explanation.

Thank you so much for your such elaborated video. It helps to clear my concepts.

Brilliant explanation Mike

Nicely explained. Thank you.

Thanku for this.....👏👏👏

Very great video ! easily to understand and memorize!

good and clear , easy to understand. thanks

i took good notes and learned more about sars-cov-2 virus.thanks #stayhome #alertnotanxious

Realistically video, thank you so much, Doc

Would you be kind enough to review how the virus in its relation to Cytokine Storm causes issues with coagulopathy? Thank you!

excellent!

Thanks for the explanation. Its very helpful.

Thanx.. Very good

Excellent explanation as usual, but somehow you are very underrated

Great lecture! Thank you!

Excellent and very clear Dr

Amazing video !!thank you

Wonderful lecture

Oh god , you are amazing 🤩 Keep uploading such lectures

Amazing expansion 😊

You're amazing please make a video about dialysis hemo and peritoneal

Nicely explained..thanks

Great summary!

very thorough !!

Great video

Thanks a lot from me in Germany! Very clear information.

Nice presentation

Thank you Doc, I t gave me a good understanding. I really appreciate you having done. I buried so many during the AIDS crisis and feeling like were are in the medical storm of a lifetime once again.

Very nice lecture

Very good. Thank you

Thank u for this

You really helped me through school last year and I see you are still doing amazing videos. Thank you..🙌🙌

Thank you Doc

Thank you!

great info mate...

Hey Dr. Mike and Dr Matt - Thanks ever so much for this detailed explanation of the pathophysiology of SARS-CoV-2 - My wife and I really enjoyed it! Nice one! In other news, my placement in ED was unfortunately cancelled (no more students in ED) - Totally makes sense from a risk mitigation perspective. I've been redeployed to the renal ward - Which of course is, AWESOME. The renal system is grouse! Your previous videos are helping heaps in this placement. Thanks mate. Take care!

Nice explaination 👍

Great presentation.

nice information but can you make a concept map of virus that how it links to varioussymptoms , risk factors , diagnosis and treatment please. waiting for this video

good work

Thanks sir 😍😍

Informative indeed.

I really understand the pathogenesis of the virus. Thanks very much.

Very very informative

Thanks Dr. Mike this video was really helpful. One thing that I didn't quite understand is, how does the virus inhibit the anti-inflammatory effects of AT 1-7? Does it use up the ACE2 proteins on the type 2 cells thereby reducing their availability or is their another mechanism I'm not understanding?

This is excellent information, not too technical for the lay-person (me), and very clearly explained. One thing I've not seen discussed, probably because no one knows, is the infectious dose necessary to start an an infection. My understanding is that different viruses vary widely in that regard. With HIV, for instance, I'm told that a huge dose is necessary, and that with norovirus, as few as a dozen individual viruses can be enough to start an infection and make you sick.

Thank you very much👍👍👍

Thank you so much

Thank you very much, useful video

Can you do a video on the microvascular thrombotic properties of COVID-19

It was very good presentation. Thanks for explaining so nicely. But you didn't explain the fecal oral transmission.

perfect thank you

good job !

Thank you

Thanks a lot, you make it so easy to understand. I don't even know much about medicine.

this is sooo good! pls keep making videos 😊