Dr. David Sinclair: The Biology of Slowing & Reversing Aging
Переглядів 3,284,835
День томуIn this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.
In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.
#HubermanLab #DavidSinclair #Longevity
Thank you to our sponsors:
ROKA - www.roka.com/huberman
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Magic Spoon - www.magicspoon.com/huberman
Dr. David Sinclair Links:
Lifespan Podcast: lifespanpodcast.com
Twitter: / davidasinclair
Instagram: / davidsinclairphd
UKposts: / davidsinclairpodcast
Lifespan (book): amzn.to/47MLimC
Aging Test Waitlist: www.tallyhealth.com
Harvard Lab Website: sinclair.hms.harvard.edu
Our Patreon page:
/ andrewhuberman
Supplements from Thorne:
www.thorne.com/u/huberman
Social:
Instagram - / hubermanlab
Twitter - / hubermanlab
Facebook - / hubermanlab
Website - hubermanlab.com
Newsletter - hubermanlab.com/neural-network
Timestamps:
00:00:00 Dr. David Sinclair, Harvard Medical School
00:03:30 ROKA, InsideTracker, Magic Spoon
00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging
00:10:23 What Causes Aging? The Epigenome
00:15:53 Cosmetic Aging
00:17:15 Development Never Stops, Horvath Clock
00:20:12 Puberty Rate as a Determinant of Aging Rate
00:23:00 Fasting, Hunger & Food Choices
00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy
00:34:50 Caffeine, Electrolytes
00:35:56 Blood Glucose & the Sirtuins; mTOR
00:37:55 Amino Acids: Leucine, “Pulsing”
00:44:35 Metformin, Berberine
00:50:29 Resveratrol, Wine
00:53:20 What Breaks a Fast?
00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing
01:09:10 Are Artificial Sweeteners Bad for Us?
01:12:04 Iron Load & Aging
01:15:05 Blood Work Analysis
01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary
01:26:02 Amino Acids, Plants, Antioxidants
01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen
01:40:35 Neuroplasticity & Neural Repair
01:46:19 Ice Baths, Cold Showers, “Metabolic Winter”
01:48:07 Obesity & How It Accelerates Aging, GnRH
01:52:10 Methylation, Methylene Blue, Cigarettes
01:56:17 X-Rays
01:59:00 Public Science Education, Personal Health
02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com
02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram
The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Audio Engineering: Joel Hatstat at High Jump Media
@hubermanlab 2 роки тому
The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( lifespanpodcast.com ) and here on UKposts: ukposts.info. Thank you for your interest in science!
@memastarful 2 роки тому
What a beneficial opportunity to learn and grow more. Thank you for this
@memastarful 2 роки тому
P.S.= Oh and happy almost New Year
@BS-lc5cd 2 роки тому
Type 1 diabetic here. Lots of Type 2 talk regarding longevity. I have no insulin in me, does that help me? How screwed am I
@memastarful 2 роки тому
@@BS-lc5cd my 12 year old daughter has type 1 diabetes. 8m so grateful for your question.
@rubyblu21 2 роки тому
Great interview Andrew! Thank you so much for bringing David on and asking the questions that you did, you've out done yourself yet again.
@AboodCohen 2 роки тому
Welcome to the Future everyone, where golden information like this is free and available instantly.
@sauravsingh8534 2 роки тому
We are the Future
@JC_inc 2 роки тому
. . UKposts is more than 15 yrs old.
@RichieIsRight 2 роки тому
The future is getting this info directly chipped into your brain and available immediately
@ronnieradke9240 2 роки тому
@Brett M I think you missed the point
@ronnieradke9240 2 роки тому
@@JC_inc Jesus Christ zero common sense
@kcmaxwell1509 2 роки тому
My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). He’s eaten once or twice per day for his entire life. Super interesting science. Thank you.
@sarahscottageholidaylet.5071 2 роки тому
Wow! Your Dad sounds awesome! Good for him!
@big_chungus73 2 роки тому
When someone tells a story like this, a lot of people will say or think, "That's just anecdotal." But when there are so many anecdotes pointing one direction... where there's smoke, there's fire. Love hearing stories like your Dad's, and it's inspiring for those of us half his age to continue to prioritize health and self improvement, and maybe even help others on that journey.
@luciozanela7069 2 роки тому
Dr Sinclair is an absolute genius and I am great full for his amazing work to change mankind mindset regarding aging
@gabrielkvarnberg8656 2 роки тому
low caloric intake = looking like a emaciated soyboy with no muscles.
@Zoltar1811 2 роки тому
Legend
@mss_tanja 8 місяців тому
Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen.
@sfardales 8 місяців тому
I so AGREE!
@tadasturonis 6 місяців тому
i am a man, but i totally agree, lol
@drironmom6815 5 місяців тому
Definitely! 😅
@squamish4244 5 місяців тому
I think he's spreading himself too thin, though. He's been firing off these podcasts so rapidly, and I just want to say, dude, slooooow down. You're going to burn through all your best potential guests quickly, and it's too much for a lot of us to absorb anyway.
@555SwissMiss 3 місяці тому
😂❤
@peterellis4262 4 місяці тому
I have to say that the obvious enthusiasm and excitement you both show as you discuss these topics is absolutely wonderful.
@akashprathod 2 роки тому
Two scientists that I follow all the time, now on one podcast. This is a Christmas gift.
@ballapalleballe 2 роки тому
Yeah! By Far the best Christmas Gift!
@paulaneves2548 2 роки тому
So true!! Same feeling here!
@newpixelsapp 2 роки тому
same here!
@lynnnestor7985 2 роки тому
Yep top Christmas inspiration from my two fav scientists. Very proud of our Aussie Sinclair🙏👌
@alok3129 2 роки тому
Bhai very nicely put!
@Livingwithadog 2 роки тому
Imagine how the internet has changed the world. You can now easily prolong your life for free because of technology and intelligent people like Andrew
@andybaldman 2 роки тому
Live-longer fads (and people making money off of them) have existed for decades.
@shealdedmon7027 2 роки тому
Just think of all the people that will live an extra week or two because of this video.
@AstroMartine 2 роки тому
resveratrol and nmn are not free though :>
@phoenixjoe5520 2 роки тому
People are gullible nowadays, a sad fact...
@orbifold4387 2 роки тому
Unfortunately it only works if you are not worried or thinking about living longer.
@KipIngram Рік тому
Absolutely LOVE how Dr. Huberman handles this - he carefully brings out all the right things. Fantastic interview!
@germandaria Рік тому
The best what I like about how Andrew is handling an interview is that he really does not interrupt. In this case its even more important than saying things.
@vickihughes9476 Рік тому
I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work!
@healingjourneys4241 Рік тому
Where do you practice?
@vickihughes926 Рік тому
@@healingjourneys4241 Illinois
@healingjourneys4241 Рік тому
@@vickihughes926 wish I was closer because you sound like a perfect physician for me.
@CollegeWebMag Рік тому
Hi Vicki, I couldn't agree with you more. I once had an older bodybuilder (72 yrs old) tell me to stay away from processed food, and you will be ok, Rudy. Thanks for your reply. Cheers! Rudy
@ey8648 Рік тому
Have fun making no cash. All the money is in the meds.
@katewenzell 2 роки тому
One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill.
@sarabutt3428 2 роки тому
Thank you for sharing your incredible story of resilience with us. I am so sorry for the trauma that you experienced and very grateful that you are housed and recovering now. My best wishes and prayers for you.
@katewenzell 2 роки тому
@@sarabutt3428 Thank you for your kind wishes
@anagroszek7743 2 роки тому
thank you for sharing your story .
@EmiKimura88 2 роки тому
I've just had an urgent desire to help homeless people
@katewenzell 2 роки тому
@@EmiKimura88 The homeless survive with the help of kind strangers, but the best way to help in the long-run is supporting the push for democratic socialism, for much stronger social safety nets, and social investment in mental health, addiction support and housing, instead of policing and criminalization of the homeless. The phenomenon of homelessness is absolutely connected to society at large and politics.
@Jbsa1998 Рік тому
I felt like I was sitting in on a lecture and I was engaged the whole time! Super informative and insightful! Thank you so much!
@wasimkmob1586 4 місяці тому
Dear Andrew, I want to give you a huge shoutout and express my gratitude for all the awesome info you're putting out there hosting such great minds and the incredible work you're doing to make education accessible. On top of all the cool science stuff, your subtle sense of humor really adds to the experience. Watching your videos is a blast! Thanks a ton!
@jaynanewbold8263 Рік тому
In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both!
@cindysmallwood2695 Рік тому
Except that Huberman really likes to hear himself talk. Questions could be summed up in half the time.
@alsin1597 Рік тому
@@cindysmallwood2695 he obviously wants to make questions as clear as possible and, in my opinion, very much succeeds. You mam, I assume, just jealous.
@thomasbeaumont8884 Рік тому
@@cindysmallwood2695 He knows he's a specimen
@thomasbeaumont8884 Рік тому
@@alsin1597 you offended on his behalf. He's a lecturer. It's undeniable he talks a lot
@alsin1597 Рік тому
@@thomasbeaumont8884 what... I am actually stand for him
@TheInterwebzMan 2 роки тому
I’m 35 now and starting to see and feel it. I swear I was 22 just yesterday. Time flies!
@54Rockit 2 роки тому
Funny, I'm 68 and 22 lives on inside, believe me and hope it never fades. Music is a great way of hold on to that time of your life.
@clarisaojedaleon3653 2 роки тому
same here bro but I look amazing xd
@skdjirrrdjdm3926 2 роки тому
Tell me about it...not only did I just turn 34 but now I look just like my mom.
@christianzwaga9434 2 роки тому
@chevalier577 tell us more
@templeray5692 2 роки тому
I'll be 37 next month time does go way to fast but at the same time I believe aging will be cured by 2035.
@hobbyfarmer1452 5 місяців тому
When I first listened to this podcast, it was about one year ago. Since then, I had listened to many other similar podcasts. I learned so much from all of them. This time listening to this one, I understood the subject so much better.
@carolfairfieldmua9040 Рік тому
Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol
@rubyblu21 2 роки тому
I knew it was only a matter of time until Dr David Sinclair made his way onto your show. Thank you Andrew!
@AgendaInMind 2 роки тому
Most of the more severe illnesses happen to people because an upsetting event occurs in their lives taking them by surprise, unexpectedly, impacting first in the brain, then in the corresponding organ which that part of the brain controls. The end of WWI had absolutely everything to do with the Flu and lung TB outbreak that occurred killing millions. In nature, the biological conflict linked with a territorial fear (just what it means-a fear in your territory, your home, your community, etc.) is a widening of the bronchia (tissue loss). Your body attempts to widen your bronchia in order to allow more air into your lungs to give you more strength and energy to fight to keep your territory safe. Stay with me.......The biological conflict linked with a death fright impacts the lungs. The lungs attempt to grow larger in order to allow more air in because breath equals life, as we all know. No breath equals death. While you are in the fear or death fright conflict, you notice no symptoms of “disease”, except you have cold hands, cold feet, you can’t sleep, you awaken at 3 AM every night, you have little appetite. During the war, millions of people were in fear of the bombing of their homes and cities where the war was most active. Fearing for their lives, their loved ones in the war, their ability to survive. The food in the stores was sparse due to shortages. This lasted for 4 long years! The longer the conflict, the worse the healing phase. Within 2 weeks of the German Chancellor announcing the end of WWI, these millions of people ALL went into the healing phase all at the same time. It is during the healing phase that you experience symptoms of illness! What is the healing phase of the bronchia widening? Severe bronchitis, pneumonia. The body attempts to refill this lost tissue and you experience inflammation, fever, coughing, body aches, fatigue, etc. What is the healing phase of the extra lung tissue that grew? Decomposing of the tissue by TB bacteria and fungi. The symptoms of this healing phase are: severe coughing up of blood and tissue, fever, inflammation, severe mucous, body aches, fatigue. During this decomposing of the extra tissue (tumor), the body expels a lot of protein, and without replenishment, severe protein loss can result in death. Antibiotics did not exist yet. If TB bacteria does not exist in a person or they have been vaccinated against TB (big mistake), then the tumor will simply encapsulate and become dormant and not harm you. Who died during the Spanish Flu? Mainly the poor who could not afford to buy meat and proper nourishment, and the people who were directly impacted by the bombings and destruction of their homes. Millions of people suffered fear and death frights during the fighting of WWI, and millions of people all went into healing at the end of it. Not everyone was affected because not everyone suffered the same way. It’s not a “flu”, it’s not something you “catch”. It’s biological, meaningful, and unavoidable. One hundred years later, a Fear Campaign begins, using the media to spread it......
@StoicAurelius1 2 роки тому
Me too, I knew it was gonna happen before the end of 2021
@RoscoeDaMule 2 роки тому
it was recorded in mid summer so it already happend a while ago
@oliround 2 роки тому
This channel/show is a gift to mankind and we should be forever grateful to this man
@sovereign775 2 роки тому
100% feel you. I am blown away when I share this podcast with others and they don't tune in
@markkash Рік тому
Thanking you very much for your brilliant work on genetic influences attaining fountain back to youth so to speak .people close to me are astonished at the bullet proof genetics I was blessed with I just turned,60 don't look day over 40 literally lived the life of a rockstar rarely ate and when I wasn't obliterated it was all about adrenaline surf snow skydiving racing motorcycles cars . never seen a depressed person dropping into 20ft wave wondering if adrenaline has benefits slowing deterioration of are meat suites
@brandonbarnes6493 7 місяців тому
Why I love Dr. Sinclair. He always answers so honestly. “We don’t know, but I’ll give you my best answer.” I appreciate you both for taking the time to educate us!
@TatooedDoc 7 місяців тому
LMAO!
@alisontomsett5248 6 місяців тому
Angina completely gone since taking reservatrol and NMN. Also doing intermittent fasting. Amazing info thank you. Life changing literally.
@ronandheather3079 2 роки тому
2 humble geniuses genuinely appreciating each other’s genius. No competition. No agenda. (Except to share) wow! What a gift indeed. Everybody loves this
@szymonbaranowski8184 2 роки тому
Sinclair promotes the greatest global experiment on human beings... so not so much agendaless... not mentioning nr of pharma businesses involved...
@Michael-gi5th 2 роки тому
@@szymonbaranowski8184 yeah I'm not so sure about NMN cause there's so much contradiction involved, some say no it doesn't get into the mitochondria of the cell so can't increase lifespan as it does in mice
@Darnabymom 2 роки тому
I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span.
@jelizabethpetrie6656 2 роки тому
Same here, 60 with 92 yo mom & 14 yo border collie. Learned applicable lessons for us all! Most appreciative 🧘♀️🚴♀️🧗♀️🚣♂️
@nebber1234 2 роки тому
Your mom had you at 40? That's amazing by itself.
@CB-ln2eb 2 роки тому
Could you share with us what they say their "secrets" are to living a long life? 🙏
@randdiamond8090 2 роки тому
@@nebber1234 In the first place, the “infertile by 36” data comes from a really high-mortality time and place 😂
@Darnabymom 2 роки тому
@@nebber1234 Actually my grandmother, who was born in 1884, had my aunt at 36 and my mom at 38. I had my daughter at 40 and our son at 43.
@supremecanine6848 Рік тому
Dr. Huberman, thanks for making the world a better and healthier place.
@bio_vet 6 місяців тому
That was a mindblow. What a conversation to shake everything we heard before about diets and health. Thank you for doing this podcast!
@xxlegitfailxx 2 роки тому
Was on the borderline of checking myself into drug treatment this month until i started reading Why We Sleep by Matthew Walker, watched a few of the podcasts in this series followed by a responsible psychedelic experience...can't explain how grateful I am for resources like yours, Dr Wakers, Dr Sinclairs etc. People don't talk enough about how diet, exercise and proper rest enable making the right decisions in other areas of your life so much easier. Normally i shitpost and troll in the comments but with 100% of my sincere-ness thank you.
@nikos4641 2 роки тому
You should probably look at "Why We Sleep" by Alexey Guzey. UKposts doesn't allow links but he implicates that the book is riddled with errors.
@sweetsue4204 2 роки тому
It’s always nice to come across someone else that this podcast is helping. Thanks for sharing, and good luck going forward. I feel pretty certain stories like yours are what they hoped to create when they kicked the podcast off. 👍🏻
@burnttoast6397 2 роки тому
@@nikos4641 what’re alexey’s certifications? Is he even qualified to try and discredit Dr. Walkers book? I highly doubt it
@nikos4641 2 роки тому
Burnt Toast I’m confused why qualifications matter; he just cites the relevant literature that goes against his claims.
@ES-ex5it 2 роки тому
Congratulations on your progress. Two books that I'd recommend: Spark by John J. Ratey, MD and Dopamine Nation by Dr. Anna Lembke. Godspeed!
@jessikalove4788 2 роки тому
I feel like Professor Huberman is my friend on the inside at this point, lol. I look forward to these weekly podcasts. Such a wealth of information. Also, he seems to have such a positive aura. Keep up the great work, Professor! ♥️
@walkerusmc07 2 роки тому
I couldnt agree more!
@CertainExposures 2 роки тому
Lol, it really does feel that way. Tossing my multivitamin today. Too much iron!
@jessikalove4788 2 роки тому
@@CertainExposures Me too!
@funtimes8296 2 роки тому
Oh girl don't lie, you wish he was more than just a friend.
@keng7758 2 роки тому
Hey Jessika, I gotta say…you are simply gorgeous! Nothing creepy…just a compliment!
@susanhenley8844 Рік тому
I am so happy to have stumbled upon this podcast and will be listening to more. Thank you!
@Niceonthefrenchriviera Рік тому
The video starts at 8:00 (for those who want to avoid the advertising and marketing) 😉
@jeanettewight6365 4 місяці тому
I skipped it too!
@1234highman Рік тому
I'm extremely impressed with Dr. Sinclair's insights on aging - it's incredible how much progress is being made in understanding our biology! I recently heard about a study that showed certain dietary modifications could extend lifespan and I'm excited to see what other discoveries we uncover on this fascinating topic!
@rarebird_82 Рік тому
Me too, stop shouting! 😘
@mermaid5948 9 місяців тому
What were the dietary modifications? Thanks 😊
@chuckleezodiac24 5 місяців тому
@@mermaid5948 according to Sinclair: Metformin, Botox, Spermidine, yogurt & plants.
@ifnotnowthenwhen9063 5 місяців тому
We Are being lied for many years.He actually pointed it out that living longer is connected to eating less which was ignored by the medic world no wonder why
@Nightowl1947 2 роки тому
What a gift for us, your audience. I do the fasting at 74 and feel great. Implementing new ways to maintain good health, never felt so good! Thank you both for you kindness and willingness to share .
@susanwoodward7485 2 роки тому
I do the same at 70, convinced I can beat the chronic kidney disease I have had since 2005, for which modern medicine offers nothing but ineffective drugs with powerful negative side effects. Never once has the concept of fasting, sirtuin pathway activation, mTOR inhibition, autophagy, NMN supplementation to increase NAD+, or stem cell regeneration crossed any of my MD's lips - criminal.
@jackparker6472 Місяць тому
Fasting is easy if you place yourself in a location where there is no food and you don't leave that location. Drink some water and get over it. It's not like being cold and getting colder. When you are hungry, you don't get more hungry. You're just hungry, and if you eat, you'll probably be hungry again in a few hours. So cowboy up.
@deniseunknown4576 Рік тому
I could listen to Dr. Sinclair for eternity. Great interview. I rarely stick around for 30 minutes much less 2 hours. So great job Andrew & David. Thank you for such amazing information. Enlightening to those of us that aren’t on that biological level of information. Eye opening. Truly appreciated.
@marywakely5550 6 місяців тому
Great info Tks So much
@marywakely5550 6 місяців тому
Q
@gabrielledavis7491 Рік тому
Thank you SO MUCH to both of you for allowing us to listen to this spectacularly insightful conversation. Us viewers are sincerely appreciative.
@lauralockie 2 роки тому
After viewing this podcast, I grabbed a copy of "Lifespan" by David Sinclair, and I was completely unprepared for what a well written, intriguing theory of life itself on our planet it would contain. Everyone should read this book to gain an understanding of the science of themselves and how to live a better life. Thank you so much for introducing us to his work!
@breadinthesesticks 2 роки тому
Just ordered mine now!
@joeanna1100 2 роки тому
are you going to take metaformin
@THEWIZARDDK2 2 роки тому
nice advertisement. did they pay you to write it ? because that also just happens to be a fact in commment with this type of weird doctors
@xxcorrosive 2 роки тому
Is it a tough read? And how long did it take you to finish it?
@lauralockie 2 роки тому
@@xxcorrosive Not a tough read, in fact there are illustrations and Dr. Sinclair isn't pompous or evangelical, in fact he's pretty humorous at times. I'm still reading it, because I skip around a lot of books at once, and even within the book.
@Kitten_Stomper 2 роки тому
For someone who's 52 yrs old and looking like that, Dr. Sinclair's an excellent ambassador for anti-aging science.
@jonluis2647 2 роки тому
He's done botox tho
@lionemporor 2 роки тому
@@jonluis2647 are you sure?
@joelcruz811 2 роки тому
@@jonluis2647 He said on Joe Rogan that he hasn’t done Botox
@TheSweetvyc 2 роки тому
He looks every bit of 52.. However, maybe if he wasn't taking all of his anti-aging supplements and taking care of himself, he would look older than that
@amoghdurgam5621 2 роки тому
@@TheSweetvyc bruh have u seen most 50 year olds?
@roljicb Рік тому
Thank you Andrew for all informations! I will try to do so as much as posible. I wish to look young as Dr.Sinclair who is 52!!! Awesome!
@kathy8389 10 місяців тому
Wow, even from the first question posed by Huberman and then Sinclair's answer to that, it's a paradigm shift. Now, will continue listening to the rest of the podcast.
@laurenwinters6897 2 роки тому
What a difference it makes to have well practiced professors explain these ideas! This is such a gift.
@AB-zq4fw 2 роки тому
Thank you Dr. Sinclair and Dr. Huberman for all you've done and do! We appreciate you 🙏
@franciscochacon5542 5 місяців тому
Thank Andrew and David. This is the best video I've ever seen about aging so far. Thank you for sharing all the good knowledge 💯
@Mohammadali_9999 Рік тому
I love you Mr.Huberman, I've said it before and say it again, you are my hero. Wish you the best,from Iran.
@lotfibouhedjeur 2 роки тому
Both of my favorite professors get together! This was so exciting I could listen to them all day. I love how they treat anyone who gets close enough as a potential science experiment 😂 Thank you both for making this happen.
@motherofcrows5911 2 роки тому
Every time I hear Sinclair talk I learn something new. Your interview here was just perfect and covered a wide range of actionable longevity strategies.
@adrianbalteanu6095 6 місяців тому
Andrew, fantastic job! You've placed all the right questions in order to complete the image of what Dr. David's explained, great work!
@JesseStevenPollom 3 місяці тому
I can’t believe this content is free. Thanks docs!
@hariprasanth2727 2 роки тому
This was the collab I was eagerly waiting for. I am a researcher in robotics and I am very excited to learn about a topic that is completely out of my research interest all because of you how interesting you guys made this. Thanks for all this work
@stevegreen65 Рік тому
I love Dave. He is such a smart guy, has a great sense of humor and he is able to break down complicated subjects in easy to understand pieces.
@andreaslynen6113 Рік тому
So great. Dr. Sinclair and you changed my live. I read his book. Great interview. Thanks so much🙏🙏🙏
@avinashrockstar 9 місяців тому
Great job Huber🎉 All your videos should get language subtitles for most of the used languages so that it reaches all over the world.
@JeffNixonComedy 2 роки тому
Just finished reading Lifespan last night and now waking up to this podcast. Pretty sure this means I’ll never die. Hell ya, time to get into hobbyist sky-diving!
@MMyL7 2 роки тому
😂 😂 😂
@avaidn7451 2 роки тому
🤔🤔🤔
@zorabw8948 2 роки тому
You should really do a parachute tandem jump. It is an unforgettable experience.
@paduraruovidiu201 Рік тому
I believe this is the 7th episode I'm listening to, in the past 4 days. Thank you again, Mr Huberman!
@scotchbarrel4429 2 місяці тому
Your line of questioning, and thought process is on another level here. It maybe the dynamic between the two of you, or maybe the time period. A solid four days of intermittent listening/digesting, thanks Docs 👊😎
@mohamadhasanansarizadeh7420 6 місяців тому
Super informative, I really enjoyed it as a researcher in the biotech field. this is perfect to share such videos and making them viral instead of superficial medical suggestion on social media
@allangraham3649 2 роки тому
Thank you to yourself and David for your time and to everyone involved in making these happen as ever !
@ES-ex5it 2 роки тому
I have watched many hours of David Sinclair interviews and I was able to gain new insight thanks to your interviewing skills. You posed certain questions with a clinical edge that other interviewers lacked, and you also relayed questions that "lay people"/non-scientists asked you. It was very well rounded and accesible. The timing of the podcast is great too. As we approach the new year it is refreshing to have scientifically proven ways to improve one's life paired with actionable steps. Thank you for this interview.
@filomelavarisco8183 Рік тому
So interesting! I could listen to David Sinclair all day long
@MB-my5kc 11 місяців тому
Thank you both for this most informative share. Health is wealth and knowing how to achieve that is key. Thank you for your transparency, so very refreshing!
@jonathandaniels5825 2 роки тому
This was the best interview of Dr. Sinclair and I've seen a lot of these interviews over the years. Too many times interviewers ask Dr. Sinclair questions that his book or prior podcasts answer. You asked some to unassumingly baseline an understanding and go further to ask questions I would have asked (e.g., dietary cholesterol, iron, finer protocol practices, etc). We got answers we hadn't heard before. Nicely done!
@dannypiper383 2 роки тому
Time flew by while I watched this 2 hours and 10-minute video; it was equivalent to watching a great movie. It's refreshing to see the dialog and hear unfiltered information directly from the source instead of through an intermediator. A wide array of subject matter was extrapolated from this podcast. Well done!
@jonahalldors5488 8 місяців тому
Thank you both for a fantastic podcast, I can’t thank you enough for your great work and for sharing this with us ❤
@susanstultzhauss132 2 роки тому
Dr Huberman and Dr Sinclair. Thank you so much for sharing your passion and knowledge, for free, with us!! It is very frustrating that a lot of sources want you to buy their book first or pay for the "secrets". I loved this podcast!!
@Borromeo377 2 роки тому
My two favourite scientists who I deeply admire 🙌🏼 Thank you Andrew for bringing David to your podcast 🙏🏼 I am grateful to both of you for sharing your precious knowledge and experience with us ❤️❤️❤️
@anyaturker412 Рік тому
Brilliant ! ❤❤❤ so very impressive to hear about your great grand parents winning the NOBEL PRIZE with critical periods (The apple does not fall far from the tree). Can you PLEASE do a podcast specifically how to reopen critical periods even if briefly due to infants getting ill during a critical period and having long term developmental issues ? PLEASE? This would be incredibly helpful. THANK YOU SO MUCH for sharing all this information with the public, truly brilliant !
@Susan-L193 8 місяців тому
I freaking love this conversation! Wow, the iron levels. When I was pregnant with my first child I was advised strongly by my doctor to take iron. I did so, and when my daughter was born, I could smell the iron in her/our blood! That frightened me and have only ever taken it in moderation and rarely since then. Fast forward two years, the same daughter was pale in skin tone as she inherited her father's celtic skin, and a different doctor was concerned but at least didn't go hard on advising supplements and I knew her diet was good. Fast forward a few decades and when I started donating blood, noticed my iron level was lower each time I donated, so I limited my donations to annually despite being told that it is 'safe' to do this every 6 weeks. It is so refreshing to hear the science with acknowledgements that everyone is different, as is our upbringing.
@shaktirising3854 4 місяці тому
Only trust yourself... YOU are the expert on your body, if it feels off, it is.
@treyd3433 2 роки тому
Stuff like this is a representation of some of best attributes of our species. Thank you doctors for sharing your knowledge!!
@anonona1 Рік тому
I just watched the "best gratitude practices" episode, where he shows one of the best ways to practice gratitude is to replay a story of someone being genuinely grateful to someone else, and here Andrew himself provides us with that story, such a heartfelt moment. Thank you both for all you've done.
@mayday24916 5 місяців тому
Sinclair, Huberman, Patrick.... all 3 of you have changed my life.
@tonyz7216 2 місяці тому
Who's Patrick?
@feelingoffbalance Місяць тому
Rhonda Patrick
@nancyreilly1873 8 місяців тому
Please accept an infinite Thank you Dr. David Sinclair and the one and only Huberman.
@potbellygoblin2495 Рік тому
thanks for putting education stuff out there for everyone. I never adapted well to the standard educational system and didn't do well at college, but I still love learning. Thanks to this kind of content I can still feel like I am learning and broadening my horizons.
@abdulsattarali8220 Рік тому
Truly what these incredible human beings are doing is amazing. People should follow their findings and listen to their advise and try to live healthy life and keep helping others. Together we need to spread this information as much as possible.
@tijen_ Рік тому
My father lived to be 90 years old; my mother is a healthy 93 year old. In my opinion, their longevity is based on good genes, a healthy vegetable heavy; meat light diet and, a physically active and social life style. We have a citrus orchard & they ate a lot of citrus fruits. Perhaps, vitamin C can take some credit too. Most of their senior years they lived in a Blue Zone, south-western corner of Turkiye where the seas Aegean and Mediterranean meet. There are four seasons and only summers are hot. I have been told by a doctor that continuously living in a hot climate tends to result in shorter life spans.
@angelamontes9571 Рік тому
Love you guys , congratulations on this amazing program ! ❤
@raquelvidales7568 Рік тому
Thank you Andrew for this awesome podcast! I’ve read Dr Sinclair’s book, and I’m so grateful that you have covered a lot of open questions that are not so easy to Digest, specially for the non-scientific people (like me). It really helped me and clarified a lot of the Q’s I had myself, and that you have covered them in a very easy going chat with him, by sharing, discussing and doing a deep dive on how the ageing can be reversed and so forth… it was such a great idea on inviting him to your show! I’m looking forward for your next updates and shows!
@ssiddarth 2 роки тому
This conversation is like one of the best Christmas gifts ever, thanks Dr Huberman for having Dr Sinclair on the podcast and asking such great questions
@vka82055 Рік тому
Very excited about these facts we can apply to our lives instantly with amazing results❣ Many thanks to you and David Sinclair!
@BloomByCC 9 місяців тому
Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population.
@billkemp9315 2 роки тому
Great podcast! I always love to hear what David has to say and you Andrew ask all the right questions.
@samuraiyun219 2 роки тому
I'd love to see a podcast on Discipline and raising conscientiousness.
@MMyL7 2 роки тому
Such a great idea, after having the 3rd percentil on the Jordan Peterson's personnality test in conscientiousness, I need help 😂
@BuddhishMusic 2 роки тому
@@MMyL7 lol same here
@yuliyahrybachova6473 2 роки тому
Yes, yes, yes
@samuraiyun219 2 роки тому
The advice is essentially to have a long term plan (future authoring can help with this - I got it, it's pretty good), make a schedule (Google calendar is fine to use), try following it alittle more than the day before, start small you will improve. Paraphrasing, he said more but that's all I remember and it's pretty useful imo.
@MMyL7 2 роки тому
@@samuraiyun219 wow thank you!
@annap214 8 місяців тому
People really thirst for this type of information!~ thank you for sharing all the amazing and extremely useful information in this channel ❤
@wboyle9721 9 місяців тому
One of the best channels on you tube full of great science information plus it is free to watch
@caliskanutkan 2 роки тому
I can't even dare to explain how valuable this podcast was. Thank you very much! I would also LOVE to listen to your philosophical conservation. Please consider that. The youth/future needs real influencers like you guys!
@JoyOnTheDaily Рік тому
What a gift! Thank you to both of these brilliant scientists, Sinclair & Huberman, for being not only articulate in their thoughts & data, but also entertaining! I’m on my second listen & have shared with many friends & family. Great takeaways for living an optimally healthy, long life! 🤓♥️✨
@alisonmcintosh937 6 місяців тому
This was one of the most exciting things I've listened to in a long time. So interesting. Thank you both!
@michaelwellner8151 Рік тому
Thank you, gentlemen for such forward thinking about humanity moving forward in being healthy
@sharonp.6505 2 роки тому
What an amazing podcast! I've watched dozens of interviews with David Sinclair. Dr. Huberman asked different and intriguing questions that no one else has asked before. Two brilliant and forward thinking scientists together, sharing provocative ideas and insights. This podcast gets my vote for "best of 2021". Thank you!!!!i
@bernardradcliffe6240 2 роки тому
One of the all time greatest podcasts in relation to health and longevity. Thank you guys.
@erwin_888 11 місяців тому
Comment on the first minute (before watching it all): For over 3.500 years Chinese culture knows about longevity and slowing down the aging proces by prevention, medicine and health-care. Think (but not alone) QiGong, Tai Chi, Tai Yin (Chinese Yoga), Kung Fu, acupuncture, Tui Na (massage and manual therapy), cupping, plants and herbs, and so on. Based on YinYang and or 5 Elements, An integral and holistic approach for health including reversing / slowing down aging. Just start with what resonates with you, get some intel and go from there. You won't regret it. Having said that, iam gonna watch the vid now ;-) And many thanks for Andrew Huberman for his -free- series on health. I've learned a lot 🙏
@georgeyung6185 Рік тому
Thank you for reminding us simplicity and paying attention to our nutrition, body changes, and supplementing. Also changing our habits. i like using these tools to gauge my aging and my husband’s.
@thomasbeaumont8884 Рік тому
Ironic name
@mashantha Рік тому
What a brilliant podcast! In absolute awe - extremely grateful to you both for your service to humanity and your commitment to educating the public! loved this.
@y7ti3ug9t Рік тому
Quite the opposite. Filling your silly brain with nonsense and bro-science
@segfahlt 2 роки тому
This was a phenomenal discussion. Thank you both for your time, your knowledge, and your dream to bring your knowledge to the masses.
@lisabeaumont Рік тому
Fascinating conversation - I'm presently working on optimising my own health and have taken notes. Thank you. :)
@johnburton9772 Рік тому
Very informative! Useful, “actionable” trustworthy health information from scientists. 🙏🏻
@juicebox86 2 роки тому
Huberman Team; You're truly making a positive impact in my life. The information and the way in which it is presented leaves me feeling empowered. Finally caught up to your most recent podcasts after binging all last year to catch up. I look forward to being hooked to the Lifespan Podcast as well!
@meimei2630 2 роки тому
what a time to access knowledge, narration as easy as it gets and being accessible to those who seek!! thank you.
@alritchie25 Рік тому
This was a fabulous interview! I learned so much ❤
@eonoeeonoe7647 Рік тому
this is very interesting.. so many things unheard of. i hope these 2 scientists collaborate. thank you for sharing this to us.
@brianyim22 Рік тому
We’re truly in the future. Free info from the very best. Thank you Drs!
@roadrunna. Рік тому
This is still better than any movie released since this episode. Such a high repeat value I can watch it for fun sadly not with popcorns, two of my most fav scientists today
@shabuqazi86 Рік тому
maybe do it with yoghurt + resveratrol
@abigailthomas6971 Рік тому
Yessss
@aminakhan4199 Рік тому
@@shabuqazi86 p
@loverofthewordofgod4156 11 місяців тому
I have been completely ignoring movies since I found this channel.
@m.talmagemoorehead Рік тому
Andrew, Thanks for interviewing David Sinclair. Respectfully, I wish you wouldn't interrupt him so often during the interview. Thanks. You're doing great work. Keep it going, Andrew.
@DrPeacockOfficial 2 місяці тому
He barely did… 😅
@mandyb2000 Рік тому
Really good podcast, I've followed Dr Sinclair for decades, same lifestyle choices as he chosen, I'm 44...pple think I am 25, I trust his advice completely, his intelligence continues to amaze me!!
@proGamer-fg1yz Рік тому
From where did you collect the info?
@mandyb2000 Рік тому
@@proGamer-fg1yz just from online, also my parents use to fast back in the 80's for weight control, mainly my mum, (who would do OMAD)...so my ideas came from her too!
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