We need more engineers involved in independent peer-review of medical research. They're not "captured" by the system and they're good at identifying weak scientific arguments and experimental trials.

Big pharma told us that cholesterol is bad. Then they sell us Statins.

They could have used a healthy source of carbohydrates like sweet potatoes and will have the same benefit . But Oreos will bring more attention . Very well done

My dad's cholesterol level is in the 1000. He eat mostly natural foods. At 80 he still works. It's genetic.

Statins, like most pharma isn't optimal

I had tried no-carb in the early 2000s for my prediabetes,and my cholesterol went to over 400. My doctor knew there were people like me and after several years of no-carb and a heart attack he got me to eat carbs again and it dropped over 100 points very quickly. He knew for a certain cohort that switching back to carbs would help immediately. Same as we see here.

I think it is outstanding and that Dave deserves some type of medical community award for lining up his own funding for his study. It is truely an amazing and ground breaking feat!

So wonderful that a non-scientist has made such a great contribution to medical science. Not only that, but he has received interest and support from an otherwise corrupt institution.

My dad and myself were always advised to lower our cholesterol even when I was on a totally vegan diet. I was always in good shape rather athletic like my dad. I concluded at that time that the doctors had no idea what they were talking about and rejected any cholesterol medication. I found it strange that I felt super well and healthy, but they tried to medicate me. Now I am eating meat and animal fat again, and my cholesterol is the same as before when I was doing the vegan diet. I can totally relate to these findings.

I have an apple shaped figure and was brought up on a low sugar diet. I was thin all my life and started putting on weight in my forties so went on the Atkins diet and lost 10kgs over a year. I was also diagnosed with high LDL so started on statins. I stopped taking them 15yrs later and stayed on a low carb diet for weight control. In my sixties I had an angiogram which showed no heart damage to the cardiologist’s surprise as my LDL was 10. I am now 71 and still going strong.

How ironic is this that I should come across this video after eating a whole bag of oreo cookies over the last week. My real concern now thou, is will they be banned? Will they be cocidered a threat? Will they ban milk too? They go so well together! Great research.

I am a software engineer for 40 years. At 50 I had all the symptoms of comorbidity. I reviewed my diet and changed. At 62 I now have a metabolic age of 46

I am a LMHR also. Was fat and on statins for 13 or more years. Then, at age 66, I decided to try keto and tossed all processed foods and begin walking then eventually joining a gym and working with a trainer. Also ditched the statins. I lost 55 lbs in 12 months. My ldl is over 400 but Triglycerides below 60 and hdl above 110. Had a CAC score last year of 255 which is concerning but I feel it's due to years of body abuse, statin use and being borderline T2D. Never looked or felt better. Insurance won't pay for my CAC so will pay again for one next year to see if the calcium has progressed. PCP sent me to a cardiologist who stated (without any testing other than the lipid panel) that i obviously have FH (familial hypercholesterolemia) . I begged for a treadmill test (passed with flying colors!) and CAC (i had to pay for it). They prescribed a statin again but i am not taking it. Can't wait to see the results.of Dave's Citizen Science research results!

I have high cholesterol my doctor prescribed me 2 meds I ask him why 2 he said one to lower ur cholesterol and the one to protect ur liver so I told him i will not take any of the meds...

I am blown away by this data. I experienced a similar effect on my blood chemistry but I am not yet a LMHR. I have had diabetes for over 30 yrs and on insulin. I found out that diabetes is reversible and started fasting, reducing carbs and quit insulin and everything except metformin. In about 9 months my LDL went up and HDL up to 71 with Triglycerides down to 87 (they had been over 230). I used to be classified as dislipedimic. Of course my doc wants me back on statins. My lipid triad is closer to the LMHR than a diabetic. I would volunteer for a study. I am a woman, 67 and not lean mass but losing weight. His work is amazing and I can’t get over how the way my body is responding may have a very interesting explainable mechanism.

This is amazing. We need more people who think like this. Please apply this research to COVID. It's causing high ldl in healthy lean people. This could really be a game changer for people dealing with endothelial dysfunction after COVID or vax injury.

I just wanted to pop in and tell @Mobeen Syed what a stabilizing force you have been since your videos took off. I rely on you for information that's the truth. May Many blessings flow🙌🏼

My husband and I are keto for going on 3 years. His cholesterol has gone up on keto...so high that they cannot give a count for the LOL. Total was over 500. He has lost 70 lbs, has great blood pressure, hba1c of 4.8. His doctor was terrified of the cholesterol number, so we did a CAC test. His score was 129. Now he is seeing a cardiologist. Cardiologist does not want to start statins. He thinks the score may go down when we repeat the CAC in a year. In other words, keto may actually be healing a plaque problem that was pre keto.

Lovely discussion!!!! Thank you Dave Feldman

Doesn't this just indicate that the LDL model is incorrect. Highly likely that original hypothesis based on a correlation not a cause

How exciting for you as a medical educator, physician and software engineer to continue to use your mind to understand this exciting research and teach others about the mechanisms as the research unfolds! Citizen science is so very interesting and perhaps it is the only science we can trust at present. Thank you!

I have very high LDL, 62 year old. The doctor put me on statins for ten years. Started getting severe cramps and leg spasms after starting to jog, so stopped the statins. Worried I had arterial sclerosis - so had a CT calcium scan. Had zero arterial cholesterol blockage, zero calcium. Five years later, no statins, high LDL and my second CT scan shows zero arterial sclerosis!, zero calcium rating. My father's five brothers (fought in WW2, high stress, PTSD, heavy drinkers and smokers) all died of strokes or cardiac arrest - except one who was very lean.

Sorry I missed being live with you on this interview. This was great. I look forward to the next time you have Dave or Nick on live.

Wow, good man for spreading word of these important developments in human metabolism !! Thank you !!

Dr Been, this is my first time watching your program and I have to thank you! You asked EVERY ONE of the questions that were rolling around in my mind. I deeply appreciate your thinking.

There been a study that individual with low LDL have more heart attacks then ones with high LDL and also there is studies that cholesterol is important in different functions of the body. Especially the brain plus statins has lead to dementia and alzheimer.

Wow, Dave! Your ability to discuss this is so spectacular! I'm going to have to find out what you do for career is! You have brought a light for more people to better understand this subject! Thank you & Dr Syed for posting this!

Yay! Dave is doing incredible work, so happy to see him here

I have been following Dave for years! ❤

Amazing discovery and discussion. Thank you!

Great talk. I made an exception to watch this one. I rarely watch your videos anymore because there are just too many ads. I've been frustrated by the skewed view of cholesterol and insulin dysregulation for a long long time. I welcome any wave makers. Maybe this will help to reveal some truths.

This is quite illuminating to me , my daughter has gone thru this. Very great interview. Thank you so very much

Great chat Dr Been. I’ve been following Dave since 2017 and fall into the category of Lean Mass Hyper Responder.

Super interesting and important interview! Thank you Dr Been. It would be so great to check a cohort of lean hyper responders on pure lion diet carnivore. This would remove confounding factors from oxalates and other plant toxins, fiber and pre/pro/post biotics, and issues from pork, poultry, etc.

DrBean this is a good topic to follow up on. Please include some videos outlining the basics of lipid metabolism and historical background.

I think an important lesson that the Oreo/Statin experiment is highlighting as well is that not all interventions that can reduce LDL is necessarily the better option. As Dave said, Oreo was chosen on purpose as it is generally agreed that refined sugars/carbs do not bring any benefit to human health. It is even damaging in chronic excess in the context of hyperinsulinaemia and the development of insulin resistance as a normal physiological response to that excess. Long-term, insulin resistance and sugar excess becomes a problem that leads to a plethora of metabolic conditions (metabolic syndrome such as high blood pressure, obesity, T2DM, cancer, autoimmune conditions, IBS/IBD etc.). It's important to realise that the current medical intervention with regards to LDL is based on the "assumption" that LDL is "causative" in CVD/Stroke when in fact, there is no research that unequivocally demonstrate "causation" between LDL and disease but certainly establishes "association" (as with LPa as well I believe so far) which should not be completely dismissed either as he said. It's about fully understanding the mechanisms involved so we can improve intervention for the benefit of all. For example, there's much to say about the benefits of looking at hyperinsulinaemia and the Triglyceride/HDL ratio instead of LDL with regards to liver output/management of carbs and metabolic disease outcomes and prevention. So I believe that study will also help clarify whether our current interventions may actually be more detrimental to health under various circumstances (e.g. risk vs benefits of statins and other medications). It should, at the very least prompt a review of the long held "lipid hypothesis" which has already been seriously challenged by other trials such as the Minnesota coronary experiment, the Sydney heart trial and the Women's initiative trial. The message I also get from that study is that essentially, a high carbohydrate diet that reduces LDL (just as Oreo does) doesn't necessarily mean that it's a healthy approach long-term as a high carb diet has other health implications due how differently it affects our metabolism and hormonal response (e.g. insulin, leptin, ghrelin, glycation, endothelial damage via oxidation and inflammation, mitochondrial damage from ROS produced from excess glucose burning for ATP, lipotoxicity all potentially contributing to ceramides/diacylglycerol production from impaired mitochondrial fuel burning that can In turn down regulate the Glut4 cell receptors on top of the Randle process that is engaged when chronic high glucose compete with fatty acids for ATP production. All this can contribute to insulin resistance and mitochondrial toxicity/mitochondrial damage/impaired apoptosis/cancer. There is also the addiction factor of carbs/sugars). I do hope that their work will also help adjust the global dietary guidelines which has been demonising saturated fat from healthy sources of food such as unprocessed animal-based food including grass fed beef, oily fish and eggs in favour of more plant-based carbohydrate heavy alternatives and processed vegetable oils. I am hopeful for a better future where unbiased science and honest research takes centre stage again instead of the system we now have that's tainted with conflict of interests, blind ideology and prestige.

Thanks Drbeen. I was confused about my LDL and Apo-B with all other markers great, very fit, keto. Then I saw Dave getting into this and have followed his journey, parallel to mine. 10 years later still torn between Doctors Attia/Dayspring and others like Dave and Nick.

Very excited and hopeful for this new discovery. God bless

It would be good to also measure calcium levels and vitamin k

Wonderfull to see us getting space in your channel too as I find your channel useful. I am a LMHR engineer too. Been in the keto-carnivore space over ten years. Deuterium is a topic you should follow as well. A lot of politics in this genre.

Wow, I have a friend who is very fit and thin, yet with high ldl. This is fascinating. Thanks for sharing!!!

Thank you so much Drbeen for giving these two men a platform. And, also thank you for all the content that you put forward. This comes like or miracle or as a revelation to me. I fall into this possible "new phenotype." I am on statins at as my LDL is well above 300. I have tried dieting and excessive exercise to get it down, along with statins to no success. My doctor says that I'm an enigma or possibly have a genetic cause behind my conditon. I am lean, so she warns me that if I were ever to gain weight I would become diabetic. Hopefully we can find a new approach to my and others condition. Thank you.

This is a great example of individual vs "statistical" medicine.

Never know what your body is going to do-I refused statins and my cholesterol dropped when I discontinued fish oil

What else are we completely unaware of????

I used to be part of their Facebook group, LMHR's. I am 5'7", 115 lbs, and my LDL cholesterol went up to 200 during the time I was doing keto back in 2018. The funny thing is I just had a calcium heart scan last month. The result? My score was ZERO. So, I don't think the high LDL is hurting me much. (Oh, my triglycerides were 49 and my HDL was 110. It is currently similar.)

Would be interesting to know what happened to blood glucose with the sudden introduction of 100g carbs every day

Oreos to be classed with Ivermectin in 3, 2, 1.... 😂

This is fascinating! I hope more and more research can be done to provide knowledge and help to individual patients. Medicine should never be “one size fits all” but rather individualized to meet the patients needs.

This video spoke to me. My lab work came back with high cholesterol, no surprise to me in my 50s and had high cholesterol my whole life, even during my time of be healthy and high intensity work outs. Family doc has recommended statins and I do not want to take statins, so will work with cardiologist to see other options in addition to working out more and eating healthier. I'm not supporting big pharma, plus as we age more activity, less fats, sugars and less stress are important for longevity.

This explains what happened to me recently! I am not lean and my Keto diet was short term. My cholesterol numbers were tested in May 2023 and December 2023. May December Total 326 401 LDL. 236 298 HDL. 57 63 Trigly. 157 213 Chol/HDLC ratio 5.7 6.4 Non HDL chol. 268. 338 In June, age 57, I was told to lose weight, eat a Mediterranean diet, and exercise regularly. I did a short term strict Keto diet that I have done in the past. Very low calorie and very low carbs. 6 months later I was retested and shocked to see that I lost weight but my already high cholesterol numbers went even higher!

Me too! 65 female 5'1". 128. LDL almost 400 LDL. Started KETO. I won't take a statin because of it's connection to DEMENTIA. Insisted on the scan for calcium - and it came back 0%. My doctor is confused and at a loss and to quote, "We'll just watch it I guess.". Plaques - seem to be the world killers. My mother and grandmother had MS and dementia was my dad and his father. Interesting.

Wow! More proof that diet, not just pills can change things. I dropped mine with a low fat diet, and no prescription.

This reminds me of a discussion back in the 80s when a doctor then pointed out super athletes with high ldl and saying "the jury is still out on cholesterol"

I live for this!

Look at the long running Naval Aviators Study out of Pensacola Florida. They have decades of info on these people and some of these aviators are the lean with high LDL phenotype. Good data that can be used in a meta study.

I am lean and always have been. I’ve been eating low carb and my cholesterol went high. It makes no sense to me that healthier individuals show higher cholesterol. I think the diagnosis of high cholesterol is inaccurate when applying the term dangerous. I am starting to believe that the whole thing is in order to push statins. My Dr. recommended statins and I decided they were not for me and refused them. I will continue my healthy lifestyle without them.

Hopefully you will keep me apprised of your research on cold fusion.

Thanks Dr Syed for cutting thru the jargon in the comments section, simplifying that Oreos work with the thin phenotype only. David’s work indicated not all is fiat in Pharma driven cholesterol/cardio treatment these days. Thank you. Dr. T

Dear Doctor Been, Absolutely loved this video, I’ve bem following your YT channel with great interest, and your honesty in explaining/ sometimes debunking controversial medical issues, I find this really refreshing. I’ve been Keto for 5 years, had amazing results, of course this path I adopted was from a lot of online research which led me to be very interested in CVD. I coming to the conclusion that one cause of CVD is or modern high carb diet that causes inflammation and raises BP that starts the arterial damage. I recently started researching Dr Malcolm Kendrick’s hypothesis that says the current entrenched Lipid Heart hypothesis that currently demonizes LDL as causal is and always has been a false narrative, and that inflammation is causal. Have you ever thought of doing an interview with Dr Malcom Kendrick? Maybe you have and I missed it? ❤

Eat meat and eggs. Grass fed. The whole American diet is a mess. Sugar is the worst thing for u

A lot of people will run with this without thinking and start eating boxes of Oreos every day. Just like the alcoholics who turned to studies about wine and beer being good for you it becomes an excuse to drink.

Thank you!

Super interesting, that guy is incredibly smart!

Just this ‘thumbnail’ makes you my hero 🤣😂

Although I have a BMI of 29.5, I fit the description of this cohort; I used to be thin and athletic. My LDL is high, my HDL is high and my triglycerides are low. I am 71 years old. I've had the calcium test, and I am extremely low, especially for my age. I was on statins for awhile, twenty years ago, but because of side-effects, I went off. I have a deal with my cardiologist that I will go back on statins if something in my circulatory system indicates that I should. So interesting to see that I am not as much of an anomaly as I thought.

The names are Dave Feldmam and Nicholas Norwitz. It was difficult to see on a phone.

I wish this was presented in a terminology that a simple person like me could understand.

When I quit dieting everything improved. I listened to my body, but I did start to use extra virgin olive oil in cooking, balsamic vinegar, more Mediterranean and Asian diet with some few Mexican food. Added dark chocolate to it - good chocolate not cheap stuff - added homemade bread from particular flour - drink no soda - but do spend a few extra bucks on Caribou coffee for my Keurig machine - occasionally treat with frozen yogurt or lemon pie - my weight dropped and mood improved. Supplements I added 5000 IU of Vit D and a good magnesium gel cap, selenium and zinc. Dave is onto something. BTW the move to get fat out of one's diet is a disaster. More studies indicate the uptick in dementia and Alzheimer's may have to do with not enough fat - or oil in your diet - your brain needs it. I have gone to totally cooking with a good extra virgin oil and using butter NOT margarine for toast etc. I do buy good salmon filet at the Asian market and more fish. I drive to Atlanta once a month to stock up on fish at the market - worth the drive. But beef is still a good choice - you do not have to give up meat just eat a bit more fish or beans even.

This is me. I am interested in the mechanism. I reduced carb intake and my HDL and LDL went up and TRIs went down. I am a very fit 64 yr old female. CAC score zero.

I suspect that with a high HDL and low triglyceride, the predominant LDL in these individuals would be the large,buoyant LDL (harmless LDL unlikely to precipitate out into plaques) vs the small, dense LDL(harmful LDL likely to form plaque and contribute to atherosclerotic cardiovascular disease). These patients should have their elevated LDL fractionated into small,dense vs large buoyant LDL. That will likely shed light on impact to risk of atherosclerotic cardiovascular disease

I learned a bit about cholesterol and about how it's mostly involved in ' fat moving ' not plugging up your system. Then I learned about vitamin K2 which helps keep your calcium from going to the wrong places ( like your arteries )and started taking some regular. Then I quit taking the high doses of statins they had me on. Then after awhile I had blood work and they told me my cholesterol was high, but I didn't worry about it. I took it as ' there was a lot of cholesterol moving my fat around ' ( mostly out )

Thanks!

Perhaps a discussion with Dr. Rob Lustig could shed more light on the types of LDL and impact on risk for atherosclerotic cardiovascular disease. He may also shed some light on why Oreos might cause LDL to go down in someone with high HDL, low triglycerides. Please consider inviting him to discuss on your channel

Thank you

Wow , we have started carnivor diet tow weeks ago . Interested to see the results of our labs in May.

I know you tried to explain by the pizza box analogy but is there anyway with a chart that you could show how the normal body does the enery fat cycle and what happens(ed) with nicks intervention?

I was under the understanding that only oxidised LDL were contributing to risk factors as they are not reabsorbed by the liver for the usual recycling action (the empty pizza boxes being re-used) thus remaining in circulation undetected 🤔

Calcium score only correlates well with the presence of hard plaque. CT angiography would be needed to visualize soft plaque- especially using new AI systems such as those pioneered by the Elucid and Carisi imaging systems, that will revolutionize plaque assessment, not only in primary diagnosis but also to follow patients over time to sequentially monitor their disease progression or regression with ongoing dietary and therapeutic intervention.Much lower levels of radiation are used making such sequential follow- up scanning much safer.

Thanks for an interesting topic! What could be other life-style habits that affect the gene expression? Sleep quality for sure - "too little sleep also leads to high levels of LDL cholesterol, according to a study published by the Journal of Cardiovascular Nursing. What is also relevant is the quality of physical exercise, too little, optimally moderate, or too intensive?

Very interesting

Nice that Dave finally learned about transcytosis, after I commented about this for years. Sad that he still talks about endothelial damage.

I’d like to hear more and will come back. I’ve always been told I have high cholesterol and lipids, but now I turn 81 on 3/2 and I had some doctors who wanted me to take statins. They made by body in pain, so I stopped. I’ve been active my whole life, but now I’m about 200 lbs and I’m just under 5’11 female. Around 2019 I stopped walking outside because of crime and lost any trust in the general medical drs. I have and started reading and writing. So I listened to Dr Bean about vaccines, etc. I don’t like the idea of not being active, so I’ll hope I can get myself going!

I am a 59 year old climbing arborist, also a LMHR. I am excited for the current and future research to lead to the removal of the word “otherwise” from the LMHR description. I hypothesize that the LMHR phenotype IS a healthy metabolism. Not only healthy but optimal and that the high LDL is actually beneficial.

In 2018 or 2019 I read a paper where the conclusion was that people have different base levels of LDL and it was fine to have a "high-ish" LDL level if that was your base one, that you only need to worry if it goes up from your base level. Also, it said that LDL wasn't the cause of heart disease, but a marker, since the levels increased when the arteries were damaged, so it was like saying firefighters caused fires because there is a firefighter where there is a fire. The actual cause of damaged arteries were others, like taking too much sugars and things like that. To better understand if your diet was good, we needed to check the triglycerides levels. I've always have a high LDL level (in the normal range but just on the limit), same as my brothers, parents, uncles, etc., but in any case, I check it now and then. The last time I went to check my levels and talked about it to a doctor, I explained this and he told me that it was true, we're understanding better these mechanisms and as long as the triglycerides were low, I didn't have to worry too much. It turned out my triglycerides were 70 mg/dL, so he said that was totally fine.

59 years old here...just found out that I have that phenotype with whacky lipids...look out Oreos here I come!!

Go Dave!

Hi, thank you…!

Very timely; Same phenotype plus, ct heart result; clear. 🤷‍♀️

York Cardiology has good videos on this too and unbiased to any diet ideology or beliefs. Our modern food system changed before the early 1900s. Many good objective reports, studies on this.

I want to participate in this study - high HDL, LDL, ApoB and low triglycerides. Relatively healthy eater, mostly lean and moderately active.

Do you have a study that accounts for gender? Is one of my questions. My grandfather and my dad were lean as was I prior to menopause and cancer treatments. Getting things back together-diet and exercise, will probably show a continued elevated LDL. Quite often there's not a gender differentiation between gender and pre and post menopausal women.

Love you and your information!

Dr, Been and Mr. Feldman: My LDL went up... But my Triglycerides is now below 60, and as low as 47, and my HDL went up to 74 to 90 from a low of below 40. Do I not get ANY brownie points for that? ALSO, LDL in most lab results is Calculated according to a formula. If that is the case.... And BTW... My Omega-3 Index is more than 11%, a level that is generally not seen outside the Japanese, Scandinavian and the Inuit populations. I have achieved this with Fish Oil supplementation. (EPA being good for the endothelium) Also, my most recent Fasting Insulin is 6, down from 11, 2 years ago. My HOMA-IR had dropped from 2.4 two years ago to 1.3. I believe that my Insulin receptors are more Insulin Sensitive. In another year, I hope to reduce my Fasting Insulin to

It’s what they make the filling out of. They should try a second trial. One group eating the Oreo filling and the other eating the cookie part only.

This phenotype*might* be related to athletes who suddenly die of heart attack, with no apparent risk factors, maybe also tied to sugar intake at certain times? (Not a "medical practitioner", merely unfortunately deeply involved in cardiac and neurological "issues"... sometimes, looking in an unusual direction leads to surprisingly valuable findings!)

Is calcium score enough or would an angiogram be necessary to see soft plaque?

I’m eating my breakfast of 2 eggs, pork, cabbage, blueberries and banana (protein and fiber plus a sweet treat). My A1c is 5.4. CRP 0.4. Triglycerides 55.

I have been living a low carb high fat lifestyle for over 30 years. The past 6 years of those 30yrs I have been Keto for 4yrs and carno/keto for 2yrs. I have been getting my bloods done yearly. I have always had high LDLs during this period. In the beginning I was worried as it was not popular and not much science done. Being science/biology trained I was interested in why ldls were high. Hearing this I am shocked Dave has not researched the obvious about LDLs that they are made by the body as small dense particles and when carbs and sugar are injested blood sugars go up so these SD LDLs are not used for energy therefore oxidising forming large buoyant particles that clog arteries. Ken Sakaris has a 10000 person study showing this. n1 doesn't cut it. Dave doesn't mention particle size of LDLs. On low carb high fat diets SDLDLs are high fraction which is good. A lipid subtraction should be done to define the good/bad LDLs. I am amazed Drbeen is promoting this bad science.

I haven’t gone low carb per se but I started ultra running, some fasting, and displacing more of my carbs with meat and some cheese… my blood pressure lowered, my triglycerides went down but my ldl went from 103 to 144. I can’t do pure keto etc but my doctor was like “why can’t you eat salads or something” now i wonder if i should just eat some oreos before my bloodwork? So maybe the ldl is high because it is moving around in the blood instead of hanging out in the arteries? my hdl has always been high and trg in the lower range