The Anti-Aging Effect of Removing Zombie Cells [7 Studies]
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References (Cope & Paste in Search)
[1] doi:10.1172/JCI95148
[2] doi:10.1016/j.smim.2019.04.003
[3] doi:10.1093/gerona/glab002
[4] doi:10.1111/acel.13767
[5] doi:10.1007/s11357-023-00830-5
[6] doi:10.2340/actadv.v103.4475
[7] doi:10.1016/j.ebiom.2018.09.015
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#antiaging #senescence #agingbackwards
@Physionic 5 місяців тому
1 AMENDMENT POSTED BELOW First video in this series: ukposts.info/have/v-deo/bnR8haadqIV1pps.html AMENDMENT: @4:15 - it should read 'SASP', not 'SAPs'
@xntumrfo9ivrnwf 5 місяців тому
Man, if you think of cells as individual people, biology becomes this epic adventure worthy of Tolkien
@ThelmaThais1 5 місяців тому
Cells are alive...they are not people, when he say zombies he means they are half alive in the process to die apoptosis this happens all the time...
@ishheredia9626 5 місяців тому
It's called Osmosis Jones
@mowthpeece1 5 місяців тому
Yes, it really would be. Fascinating stuff.
@marknasia5293 5 місяців тому
My colon was like “you shall not pass”
@laurensargent9471 5 місяців тому
Would be an excellent way to teach biology at the HS level.
@Spartnick 5 місяців тому
I very rarely write comments, but man your content is great and way more people should watch it Keep it up!
@Physionic 5 місяців тому
I appreciate that!
@mag4926 5 місяців тому
A subjective opinion.
@lauragee3365 Місяць тому
@@Physionic question would autography with intermittent fasting work to remove zombie cells?
@dlg5485 5 місяців тому
Wouldn't routine fasting achieve the same result by way of natural atophagy? I get it, most of us aren't so good at abstaining from food, but it does seem to have amazing life extension benefits if done on a regular basis.
@kb030303 5 місяців тому
Attia had an interesting perspective about balancing benefits of fasting against potential loss of muscle. Might be worth checking out.
@dlg5485 5 місяців тому
@@kb030303 Not a fan of Attia. Watching him in interviews is so annoying because he never answers a question directly. He sounds like a politician. I've been doing 18:6 IF for 4 years and a 48 hr fast each month. I've actually added muscle in that time. Muscle loss is not an issue unless you are doing extended fasts and your diet isn't right. I don't go beyond 48 hours, which is more than long enough to trigger autophagy, and I eat a very nutrient dense meal before a 2 day fast.
@richardbreeze7898 5 місяців тому
Use exercise instead does the same thing baby.
@dlg5485 5 місяців тому
@@richardbreeze7898 Exercise alone is not as effective as fasting alone, but doing both together is obviously going to be most effective, ideally exercise toward the end of your daily fast. That's what I do and I am in the best health of my entire 55 yrs.
@richardbreeze7898 5 місяців тому
@dlg5485 it's overrated baby.
@atabetuatara 5 місяців тому
Hi Nic. Left me aching for more! Great video!
@abc_cba 5 місяців тому
Next topic : How to keep skin youthful and wrinkle-free, please! 😢
@incognitotorpedo42 5 місяців тому
sunscreen every day.
@watttylerthesecond7056 5 місяців тому
Hyaluronic acid,Astaxanthin,collagen.
@spakchitown 2 місяці тому
If all college professors presented like you, how much more would we all get out of advanced education? A lot more. Compelling, succinct yet thorough. Usually my eyes glaze over at these levels of detail but not with the way you communicate. Thanks for also not being snarky.
@InsolentVillager 5 місяців тому
An NLM article I'd like your thoughts on. "The flavonoid quercetin inhibits thyroid-restricted genes expression ..." "In a previous report, we showed that quercetin inhibits thyroid-cell growth and iodide uptake. The latter effect was associated with down-regulation of sodium/iodide symporter gene expression."
@michaelcalibri3620 5 місяців тому
Thanks for that. I definitely needed to know that on someone else's behalf.
@vladislavroytapel2830 5 місяців тому
yep..i noteced low iodide
@evebaker4740 4 місяці тому
Really enjoying these videos! Ty so much
@bill2292 5 місяців тому
Water only fasting seems to naturally clear out unusable cellular products, so does fasting eliminate zombies?
@kiko7723 2 місяці тому
Yes
@jimwood1062 5 місяців тому
How would Methylene Blue impact continued cell division or recovery of senescent cells?
@Chaotic313 5 місяців тому
I started down the rabbit hole of taking biohacking supplements a little over a year ago, fisetin included. One of the recommended (by a number of UKposts proponents) way to dose was a large amount for several consecutive days once a month. But I also take quercetin daily which can also act as a senolytic - a less slash and burn approach, but continuous. So when I ran out I didn't buy more, opting for the kinder gentler approach, lol. However I am considering taking it again, but on an every few months schedule. The last thing I need is a bunch of zombies messin' with my innards. Thoughts?
@baneverything5580 5 місяців тому
Are any of these in plants I can grow, especially indoors, since I grow my own salad greens, mini tomatoes, mint, watercress, peppers, etc inside in winter? I have gigantic mustard greens in my outdoor garden and a lot of turnip greens and radish plants. I did freeze several bags of wild blackberries from a 100ft long patch bordering my yard but I had to share those with raccoons, squirrels, possums and birds since it`s the only patch around here. I think those contain quercetin.
@ashleyparker1203 5 місяців тому
From what I have read, purple onions are high in quercetin and strawberries are an excellent, growable source of fisetin. Happy gardening!
@baneverything5580 5 місяців тому
I have purple onion seeds. I guess I need to order strawberry plants and try my luck. It looks like they aren`t easy in indoor hydro gardens though. @@ashleyparker1203
@silkhead44 5 місяців тому
Been taking quercetin and nac for decades
@marknasia5293 5 місяців тому
I do the liposomal Fisetin three days high dosage, but do daily liposomal quercetin along with liposomal curcumin and I feel it at the end of the three day, and do it every 28 days
@bartoszkazibudzki2729 5 місяців тому
Great insights. Last time I'm thinking about senescence in relation of integrated stress response. Do you think these topics cover themselves on some point?
@kiko7723 2 місяці тому
Good video, good explanation not too difficult to understand. Also trustworthy sources. thx
@Physionic 2 місяці тому
Thanks, Kiko. I put a lot of work into it. I appreciate it.
@annettestevens2260 5 місяців тому
Thanks
@Physionic 5 місяців тому
Merci, Anette!
@beezowdoodoozoppitybopbopb9488 5 місяців тому
Any thoughts on dry fasting supposedly being hyper effective at inducing autophagy?
@189643478 5 місяців тому
I've been taking rapamycin for almost a year now with no side effects. I wouldn't experiment with senolytics because my big worry is that we cannot be certain that they don't have off-target cell killing (like some rare stem cell population or some highly specialized immune cells that would not be detected in gross necropsy studies).
@lolerie 5 місяців тому
But stem cells all have activated telomerase they are Immortal just like cancer cells
@walkingSherpa 5 місяців тому
Hello I would be pleased if you could expand a bit if Spermidine has some , and if yes, what influence on senescent Cells
@seranonable 5 місяців тому
Will you do a video on the best OTC senolytics?
@richardbreeze7898 5 місяців тому
Nick do a video on Rapamycin and whether its a good idea. The fact its a immunosupressant is a bit worrying.
@sergey9986 5 місяців тому
Fisetin is almost identical to Quercetin from chemical standpoint is there a big difference? Many people consume Quercetin already.
@incognitotorpedo42 5 місяців тому
Fisetin is said to be a more effective senolytic. When it comes to biologic response to molecules, a single atom's difference can be a night and day difference in outcome.
@sergey9986 5 місяців тому
@@incognitotorpedo42 Could you please help me finding the proper reference?
@georgiosdaskalakis5263 5 місяців тому
brilliant video
@redemptivedialectic6787 5 місяців тому
It would be cool and interesting to hear your take on peptides.
@Physionic 5 місяців тому
Which ones?
@Froddel-xy7wg 5 місяців тому
GH secreting peptides
@redemptivedialectic6787 5 місяців тому
@Physionic there's a few like Epithalon, thymalin, and cortagen which supposedly help with anti aging. Some like BPC-157, TB-500 and Vilon which are said to help with healing tissue damage. And quite a few for Fat Loss and muscle gain including but not limited to the growth hormone releasing peptides. I took some AOD9604 and lost 15 pounds and have been able to keep it off with minimal changes to my diet
@redemptivedialectic6787 5 місяців тому
@Physionic there are also a few nootropic peptides like selank and semax which have positive anecdotal reviews.
@KunstPicker 4 місяці тому
@@Physionic delta-sleep-inducing-peptide seems really cool
@MiguePizar 5 місяців тому
Thanks for video, by the way, can you do a video about fatty15 ( c15:0)? Supposedly it's also an anti aging supplement and nobody is talking about it, like it was with NMN a few years ago when it was new. Best
@stephenwillis9571 5 місяців тому
A bit of a tease - circumin is another. I do think you should point out the dangers of senoytics - they appear ot be crucial in wound signalling and may be involved in suppressing tumours. There is some reference of one senolytic being withdrawn in the 80s irrc which some cancer patients bled to death. One or two people taking sustained high doses have reported some problems with wound healing.
@amytucker6142 5 місяців тому
I used in cancer therapy no problems
@Joe_C. 5 місяців тому
I recall reading several years ago that fisetin should be cycled in some way. I think there was one protocol that said to dose once or two consecutive days a week, and another that said to take everyday for ??two weeks?? like once per quarter 🤔... Also, fisetin by itself is VERY poorly bioavailable. I think the trick was to take with a compound extracted from either fennel or fenugreek. Can't recall which of the two, but it I know it was a 'fen'. And it also has a synergistic effect when taken with quercitin, which also has senolytic properties
@Battery-kf4vu 5 місяців тому
Fat increases the absorption of fisetin and also quercetin IIRC. I mix my fisetin and quercetin with a gram or so of olive oil and eat that every couple hours during the senolytics days.
@Joe_C. 5 місяців тому
@@Battery-kf4vu, yes true. Good addition 👍.... How do you cycle your concoction?
@Battery-kf4vu 5 місяців тому
@@Joe_C. I do one 3 day cycle every year at 51 years old. 600mg quercetin+1500mg fisetin+100mg dasatinib. I also add 400mg oleuropein, it's been shown to have a senolytic effect. To tell you the truth I don't know if it is optimal, I don't think anybody really knows what the best dosage and frequency are. So it might be better to err on the side of caution. My 2 cents.
@MightyRoy 3 місяці тому
The senolytic fisetin was not found to extend lifespan in the Interventions Testing Program (ITP), although it could be a dosage issue.
@jmc8076 5 місяців тому
@8:04 Me and most watching? No. But IMHO these days incr number would. Plug the insiders club. Offering that quality of info and format is needed now. It’s on top of my list after this phase of health challenges. ✌️
@volos_olympus 5 місяців тому
You forgot about the clinical trial done by the ITP on fisetin which showed no lifespan extension.
@steve-o7620 5 місяців тому
Since cell death is normal, how many "zombie" cells are considered normal and what point would that number be considered abnormal?
@CessnaPilot99 5 місяців тому
I liked your zombie drawing and animation! Did you draw those yourself?
@lluviahirschortega1393 5 місяців тому
Great video!! First time i heard of zombie molecules, have you heard of the opposite? The hope molecules, which I am not sure they do exists, but i heard about it all the time, thank you for the video ❤
@Battery-kf4vu 5 місяців тому
What is the optimal dosage of senolytics? Some people do 2-3 days per months but I fear it is way too much. D, Q, and F don't have very good selectivity so it may kill a lot of good cells, and also killing all the senescent cells may not be the the best thing to do. I do 3 days once per year of D+Q+F but really I have to so say it's a wild guess.
@gdiup9241 21 день тому
Would HGH help get rid of / push out senescent cells?
@Roberta-qe7km 5 місяців тому
Mr Physionic - What is your health regime?
@TJAllcot 5 місяців тому
Was that Dr. Cynthia Kenyon towards the beginning of this video?
@incognitotorpedo42 5 місяців тому
Yes.
@johnallen7230 5 місяців тому
I found a UKposts video referring to a Fisetin Flush......I've been practicing the John Hopkins recommended protocol for 3 months......👍👍👍
@jackbuaer3828 5 місяців тому
I am going to guess that neither John Hopkins nor the Mayo Clinic is recommending that you do a supplement program to reduce senescent cells at this point in time.
@jodyjackson5475 5 місяців тому
Maybe so but I very much doubt that Johns Hopkins would
@george6252 5 місяців тому
I've been using Grape Seed Extract a couple times a week for zombie cells.
@whatthefunction9140 5 місяців тому
Is it bad that I took quercetin for like 6 months...?
@JustAnotherYoutubeHandle666 5 місяців тому
I watched another video about how fisetin probably won’t work on humans. That mouse study used a bunch of inbred, genetically similar mice and when fisetin was used on genetically diverse mice they saw no positive or harmful effects.
@Corteum 5 місяців тому
It does work ron humans. Do more researrch.
@JustAnotherYoutubeHandle666 5 місяців тому
@@Corteum Look up who paid for the studies. If the study was done by a lab owned by a company that sells fisetin supplements then you're just being fooled. Unbiased, third party labs called, "Intervention Testing Programs" have shown that fisetin did nothing to senescent cells.
@stephenbrickwood1602 5 місяців тому
Long term lock or loss ?????? at 3.45
@gristlevonraben Місяць тому
Soursop fruit helps fight cysts and cancers by helping the body recognize bad cells and foreign intruders, through protein markets, I thought. Is soursop fruit, graviola, a silenescent?
@MarcMallary 5 місяців тому
You mentioned quercitin. It's a lot more natural.
@JustAnotherYoutubeHandle666 5 місяців тому
Anthrax is natural too. Natural doesn’t mean anything.
@grego4835 5 місяців тому
Do you sauna for this effect?
@MN76. 5 місяців тому
Interesting 👍🏻✌🏻
@user-ik7rk7lz9p 5 місяців тому
Omega-3 Fatty Acid And Anti Aging? Butter And Anti Aging? 15 Years Old Ask.
@rejiequimiguing3739 5 місяців тому
Keep the fasting insulin at minimum. That's the best strategy to slow down aging process.
@Dan-dg9pi 5 місяців тому
This video might have been better timed for Halloween!
@Physionic 5 місяців тому
Honestly, I really tried to make that happen. The idea came to me about a month before Halloween, but doing all the research, writing the notes, creating the illustrations, paying the editors to edit 5 videos, and then doing the background work post editing wasn't feasible in 4 weeks. I definitely tried, though! :)
@free_spirit1 4 місяці тому
Those UV damage spots some people have on their skin... are those senescent cells? Is that the reason Bryan Johnsom lasers his skin?
@misiukowalski5653 3 місяці тому
Hey babe, I’m not that smart but I need get rid of my zombie cells ASAP what do I do!!!!?!?
@totmirmis 5 місяців тому
if the zombie cells call the immunesystem, and inflamation does happen, why doesn't the immune cells gobble up the zombie cells?
@markaguilera493 5 місяців тому
Does fasting get rid of senescent cells?
@mowthpeece1 5 місяців тому
Yes.
@user255 5 місяців тому
No.
@incognitotorpedo42 5 місяців тому
Maybe, Maybe not.
@markaguilera493 5 місяців тому
@@incognitotorpedo42 🥇
@theshadow8008 5 місяців тому
Epigenetic-induce deregulation of longevity genes.
@Nthompson50000 5 місяців тому
seems like messing with this could be a costly double edged sword
@_chimera_ 5 місяців тому
You look like you need to get rest and fluids. The cells will still be there once you recover ❤
@ZappyOh 5 місяців тому
In Danish, Fisetin would mean Farting-metal ... Just sayin'
@Physionic 5 місяців тому
How can it NOT be effective, then? ;-)
@bytefu 5 місяців тому
Good name for a genre of metal. Such a genre may not be "officially" recognized by the metal community, but there are definitely many bands that play it.
@WattisWatts 5 місяців тому
Who (or what) are we trying to make ourselves perpetually young and strong for?
@louisemorgan3237 5 місяців тому
Who do you want to get old and weak for
@rejiequimiguing3739 5 місяців тому
You want to be in wheelchair for 3 years before you die?
@WattisWatts 5 місяців тому
Why are comments assuming I want to be old and sick?
@ericzimmerman7775 5 місяців тому
Review your original question…
@MyBeautifulHealth 5 місяців тому
My children, and potential grandchildren. I want to be here for them as long as possible.
@petervafeades4095 5 місяців тому
the ITP found fisetin ineffective
@incognitotorpedo42 5 місяців тому
Don't they only look at lifespan? Nick mentioned that senolytics seem to improve healthspan more than lifespan.
@manvsmachine1 5 місяців тому
Wasn't there evidence that Metformin could kill these cells?
@andrewchoi5808 5 місяців тому
#DefeatAging #AntiAging
@todrichards1105 5 місяців тому
Oof! Nick! At 15 seconds in, you say, “extremely unique..,” C’mon brother, you’re better than that. :)
@Physionic 5 місяців тому
I don't understand? Something can't be varying levels of unique?
@todrichards1105 5 місяців тому
@@Physionic unique means one of a kind.
@marcv2648 5 місяців тому
Why do you always say SASPs, but write SAPs?
@Physionic 5 місяців тому
My illustrator, not me. Not sure why. Simple mistake, not a big deal.
@man_at_the_end_of_time 5 місяців тому
How is Aubrey de Grey is doing these days? This topic was his bread and butter.
@susymay7831 5 місяців тому
Exercise is a senoletic
@StyleshStorm 5 місяців тому
I've heard my granpap talk about this before but I ignored him mostly because he doesn't know any new science. However. Now that he's talking about this topic I now know it's real and worthy of attention. Let's see.
@user-ik7rk7lz9p 5 місяців тому
"Foxo Gene".
@cedarabbey 5 місяців тому
God, you're so cute.
@LowHangingFruitForest 5 місяців тому
But zombies don’t age? Shouldn’t we be multiplying the zombie cells?
@jayrawlings8938 5 місяців тому
Wear a white shirt or something my man. You need to represent your intelligence with slickness. Great work though!
@ausmiku 5 місяців тому
It's a waste of time designing anti-aging drugs. None of them will ever control all the mechanisms of aging at the same time. Even if senescence is controlled, aging will still occur from all the other triggers. All the anti-aging clickbait is a sick joke.
@rosaflorpuig3971 5 місяців тому
Nick… I thought the Interventions Testing Program concluded that Fisiten had no effect on removing senescent cells. This is very confusing. Please advise.
@Physionic 5 місяців тому
I’ll need to look into it :)
@rosaflorpuig3971 5 місяців тому
@@Physionic Thank you! I love your channnel!
@sweetness583 5 місяців тому
I read an article that explained why senescent cells aren't all bad.
@Physionic 5 місяців тому
They aren’t, it’s true.
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