Amazing how much younger he looks, 7 years later.

Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc.

your analogy of the broken marriage of genomes was the best part....

After this watch a recent video of him. Six years later he is visibly younger.

I just turned 70 and I feel great.

You are very competent and humble, Dr. Sinclair. Pls explain how we get NAD...

I like the joy he has

The world is watching you Dr. David Sinclair.. You are our hope..

Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!!

OMG.. He is just genious.. Everyone please support Dr. David Sinclair.. He is doing a fantastic job.. God bless you..

I love when he smiles as is a good thing happening! 😊

I volunteer for that aging research!!

Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India.

sleep, nutrition, movement, absence of stress, good emotions +++

Excellent lesson and info. Thx

so glad I found this . . Been on NAD, 100 mg. /day for almost 2 1/2 years along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters and at 72 function and perform as a man many years younger but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth.

I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body.

Thank you for the information.

Thanks it is fascinating!

Wow loved this video!! Thank you David!

So exciting! One can try a lot of this right now, and very safely. My goal is to live heathfully for however long I do live, and this research is exactly the ticket.

Very succinct explanation !

Very informative information 👍🙏

I understood everything!

Incredible - now I just need to find a reason to live - lol

Thanks it is fascinating

excellent.thanks

Amazing wow its good for me to enjoy my life with my family.

Great talk theorizing the future of mitochondrial development as related to aging and longevity,

INCREDIBLE

No so Serious Science! Love it 😀

The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is.

Thank you very much.

Great lecture, sounds like the progression of insulin resistance. Thank you

I love this so much

Cool video and understandable.

The price for The NAD Treatment Center Detox Method can range between $6,000 to $17,000, depending on the specific program that is recommended for you and discussed with NAD Treatment Center staff. For reference, a typical 10-day treatment is $11,850.

Every medical professionals should learn this.

Such a lovely man 💫

Thank Dr Sinclair. Can you please talk about fisetin! ? How we can take? I understand that it help the mitochondrial function! 🙏🏼🍀

Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge. You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives.....

Congratulations Its help a lot.to have hope in many people wants to have long happy life.

Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ..., 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point.

Excellent Research Belfast Ireland 🇮🇪 😎

what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane. i know South Korea has developed a healthy mitochondria injection method. and England has their mitochondrial donor program for three parent babies. Is there a connection between mitochondrial fuction and telomere? i wonder.

thanks for caring and sharing

Excellent. A very well spoken Professor. I have so many questions! Would taking NADH assist in this regeneration??

Amazing

Thanks for this. Reduce inflammation!

I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model."

So where do you find this magical "NAD" in nature? Please say donuts

Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these.

2014 pretty old news has anyone an update? It is possible now to get all the supplements to keep the krebs cycle humming and the ETC working including adjusting the nad+/nadh ratio. I am sure lots f people have tried it. It would be interesting if they would post there results. Although the only test might be still healthy at an advancing age?

Sinclair looks younger now that he is 50

How do we know the nucleus makes the proteins?

The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons.

Well yeah !

Does NAD help people with MS?

Lelouch: Suzaku live. Suzak: Should i take NMN, Metformin and resveratrol like Sinclair. Code Geass

what about the supplement Ubiquinol( Co enzyme Q10) this is supposed to raise atp production?

What’s the best NAD supplement on the market? I’ve done NAD IV treatments before (you feel TERRIBLE while doing them) but that goes away pretty quick when it’s finished. My primary concern is anxiety, brain fog and fatigue.

He definitely looks younger now, wow

I have parkinson disease can you give me advice please

"I do not want to live forever in the memory of the people. I want to live forever in my apartment." Woody Allan

Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations?

Did it work out (this video is 8 years old by now)?

NMN cause elevated homocysteine. Please advise

doed the dr take it ?

I really enjoyed your video. 8have life extension instruments

What are the natural ways of increasing DNA content of cell

David Sinclair looked older when he was younger & now he's older 7 years later he's looking younger.

is it bioavailable orally? does it only restore muscles to a youthful state or all cells and that is just the example he used towards the end of the video?

What can we do now...what really work.to slow or reverse it now....nad.plus.

I am nearly 65 and have found that taking a small amount of D-Ribose and some Creatine daily has given me a massive amount of energy and strength so much so that two or three days a week, I will run a 5K followed by an hour in the gym doing a heavy workout and then do about 3/4 hour of swimming and still feel like I could do more. I suspect am as fit as I was in my twenties.

I love anti aging science I am Amercan Board certified Endocrinlogist could you give some trading in this new science or rather do you offer fellowship in antiaging?

Got to hand it to him. He does look younger now than he did back then.

So what food makes this?

So if i have less functionality of mitochondrial DNA or i dont make enough of it when young i would die of a lack of cells with enough energy to run a marathon, when i am older, i am so glad it will happen later than earlier in life, but when is the cut off point when mitochondrial DNA start to grow less useful

Ok what’s up with this niacinamide and nicotinamide are they the same? Please explain anyone

This is almost 6 years ago and he looks younger now...

Did he say we are not living much longer than we did 10,000 years ago? How does he come to that conclusion and on based of what data?

Whats a safe real NMN brand please?

Notice his eyes.... no jaundice like 75% of other people. Also look at his knuckles no edema no tremors and no mandibular deformation from poor dental health..... I trust him. Did you know he wrote a book on this in 2019?

L Dopa is converted to Dopaquinone and then to melanin by an Enzyme tyrosinase I think Vit k2 has something to do with it?.

One of the sexiest scientists out there.

His own appearance has also changed quite drastically if you look at him today, i swear, his five years younger today, five years later, so his own concoctions seems to work..

Creatine supplements can increase atp production. Any correlation to this topic?

You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both.

You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length.

I use every day

I thought this video was made in 2021, because he looks exactly the same today. Something's working.

Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available. One thing which I never understood about is free radical? According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death. Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created .... So please do make me understand about free radicals Doctor Thankyou

Looks like David Sinclair's methods are working. In his latest videos he looks younger than he was 9 years back.

great

Exactly

Great

NAD OR NMN OR RESERVATROL?

I have tried Niagen about a week ago , Im still sceptical but, I have(had ) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair

We all want to live forever. I do not want ever to die I love the universe my home, my father in the havens, love animals. Love my family, love people, love to smell the flowers, hear the birds singing. Love to fall in love. God bless as all creatures big and small.❤❤❤❤❤🙏🙏🙏🙏🙏🙏🥰

Ketosis increases NAD+ to fight off inflammation