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This is the second installment of a series dedicated to the molecular biology of the highly unusual and deadly turbo cancers (called hyperprogressive disease in medicine). In this episode, we look at how IgG4 can play a role by itself in cancer progression via its Fc stalk and its ability to interact with either other cancer-fighting IgG1 (and preventing their protective role) or by blocking immune cells from performing their protective roles.
What we cover:
*Cancer patients showed 11% IgG4 levels of total IgG antibodies in comparison to 3% in healthy subjects
*IgG4 levels positively correlated with the stage of cancer
*IgG4 level/total amount of IgG can be prognostic of cancer recurrence (past studies)
*IgG4 is about 4X higher in cancer tissue than adjacent tissue
*IgG4 can bind to anti-cancer IgG1 antibodies and inhibit their function
*IgG4 does not have to target the cancer itself at all to help cancer growth
*Co-injection of IgG4 of any type with cancer cells into mice always increases the tumor size/weight
*It is the Fc stalk of IgG4 antibody that is responsible for its pro-tumor effects
Location: Yamnusca Mountain, Alberta
Described content:
jitc.bmj.com/content/8/2/e000661
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Dr. Raszek Credentials: merogenomics.ca/en/about/
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