She is an amazing educator. I am grateful to be able to access high quality lecture like this for free.

Imagine the world we'd craft for ourselves if all science was communicated so brilliantly and unpretentiously. Bravo.

This has to be one of the most interesting presentations I've seen in a while. Absolutely fascinating.

I'm here after reading her book "The Epigenetics Revolution" to learn about possible updates in the field since it came out a few years ago. I would highly suggest the book to anyone as I had no background knowledge other than high school Biology and yet every chapter would blow me away.

The 8 proteins are histones and form a protein complex known as a histone octamer, which is spool shaped (marshmallows were used in the demonstration). The 8 proteins in the histone octamer are actually 2 copies of 4 proteins, H2A, H2B, H3 and H4. DNA wraps around the histone octamer known as a nucleosome and they form chains like beads on a string making up chromatin. A nucleosome can be defined as a small length of DNA wrapped around eight histone proteins. The key difference between chromatin and nucleosome is that chromatin is a whole structure of complex DNA and proteins while nucleosome is a basic unit of chromatin. The beads on a string make up something called euchromatin or open chromatin that is enriched in genes and active under transcription (transfer of genetic instructions) which is why it is so important in epigenetics and changes in the phenotype (physical traits- e.g. appearance).

I absolutely have to watch this again and again. She has few equals in terms of clarity and lucidity. I am going to forward this to my entire family. One of the most interesting topics explained by one of the best presenters.

This was the the biggest eye opener for me in the past years. This knowledge opens so many doors.

Finally! we have an exciting, summation of information about this field! Thank you for posting. Best explanations, clear analogies and diagrams I've ever found .I've been interested in this field for many years, though no longer a formal student. This great video brings me up to date.

Amazing lecture! She takes complicated information and breaks it down into interesting info using jokes, history, stories, movies and more! Brilliant!

Wonderful talk! I can't get enough of these Royal Institution lectures.

This is absolutely incredible! I'm completely floored.

We really need epigenetics to advance as a civilization, some might even say it's... nessacarey

You make it so easy to absorb! You're an amazing professor! Thank you!

What a great presentation. Loved it!

Thank Nessa, it is my pleasure to attend your tutorial today at MCRS

fantastic delivery of a fantastically fascinating subject -- thoroughly enjoyable, especially being a twin myself.

Superb presentation skills! Just the right amount of humor, story telling and information transfer to resonate with almost everyone.

Fascinating subject, i'd never heard of this subject before. Props to the lecturer for giving such an entertaining lecture on a complicated subject! I hope you have her back again.

Absolutely brilliant presentation. I just wanted to learn a little for my pathophysiology class and left amazed!

What an incredible communicator. Science needs many more with her skill.

Thank you for the very fascinating and lively lecture! I love it!

So well done. Answered questions I didn't know I had.

I'm currently reading 'Junk DNA' and I can assure you that it is really informative and it doesn't bore you. As a first-year medical college student, it is really helpful to visualize the epigenetic differentiation. Examples she gives are hilarious.

Fascinating. Interesting material and very well done presentation.

How fortunate that I in india can access this extraordinary lecture delivered so well and generously sprinkled with humor. Great contribution to science education. Have her books which are so precious for me

Extremely clarifying presentation, her book is also a gem of science communication...

Such an amazing talk ma'am..really really loved it to the core...

Reading her book now after watching this a few months ago! Brilliant and exciting literature! Epigenetics is such a fascinating field! This is telling us how we can affect our future progeny!

Thank you for uploading. Very interesting☺️

I really enjoyed this talk thank you

Her book, The Epigenetics Revolution, is fantastic by the way.

all i can give to this lady is 🙇 Respect! amaizing

SO intriguing! How the things, habits, nutrients we do now can genetically modify our future progeny!

She destroys it. Good talk. Her book gets a bit complicated at times but this is spot on.

Really good - packed with interesting insights and good for the RI to tackle what is admittedly a controversial topic.

thank you for sharing

What a spectacular lecture!

What a BRILLIANT educated and informative video, love it!

What a brilliant lady!

Outstanding presentation. Very clear. Congratulations!!!!

Its really a great lecture never had idea management student can enjoy science.

Fascinating, fascinating, fascinating. Absolutely fascinating.

First-rate presentation on this topic. Thanks very much.

Extraordinary lecture, thank you. blessings, Kimmy

Its all actually very simple to understand when you grasp what is actually occurring in terms of epigentics and how we are products of evolution - genetics and events - what we do and what is done to us

A great way to transmit knowledge

I'd love her as a professor for all my bio classes

Excellent; thanks for your great work.

excellent video to describe epigentics, its a subject i wanted to write on next for my blog.

thank you so very much. This is wonderful. I am glad to say I was wrong.

First time i am watching her. Today I purchased her book " The Epigenetics Revolution. Not my subject. But i have interest. Happy to watch. Thank you Madam. Regards

Outstanding presentation

Great talk

I would very much like to hear professor Carey's view on the mRNA vaccines and their potential influence on the human epigenetics!

She's great ! ❤️

Great lecture!

Great presentation. And she's just a natural. Very entertaining. 🙂

Great delivery

Just wonderful! 🧬

An awesome presentation.

Interesting topic, delightful presentation.

well done and entertaining presentation on the topic of epigenetics

Well worth the listen! Thank you mame

Will be buying her book

So much to love about this. Even all these years later rewatching it still give me all those uh-huh feelings.

brilliant

Amazing teaching learning knowledge about the modification and genetic codes sequence of genome 🙏🙏👏👏❤️❤️💐💐

The DNA code starts from the same then the coding changes but the DNA coding is all the same in the start of the code. Example is like computer coding. Code DNAMOMDAD then add on EYESLASHES or DNADADMOM Liver etc etc. It's so damn AMAZING

Wow, really enjoyed this lecture. Any sociological/psychological applications or assumptions linked to these findings? ie, poverty, oppression, consistent trauma etc...

THANK you now I kind of get it

EXCELLENT

What a great woman !

Brilliant Thanks

Absolutely love her x

One of the best speakers I've seen on this channel. We need more sweets-based analogies in scientific discourse.

Crocodiles and Dinosaurs share a common ancestor, crocs are not descended directly from dinosaurs. Brilliant talk, especially your dna analogies

Fantastic, Love the energy your brought to your book The Epigenetics Revolution" I wonder if you can see the link between Epigenetics and Buddhist Karma. (They are both very deep matters) Any Buddhist's out there pls read this and think....

This is EPIC!! Lamarck is partly vindicated, but that's the least of it. We are more "adjustable" than we realized before, and some of these adjustments can be passed on to the next generation. LOTS to think about, even for the ordinary person in the street who wants their offspring to be healthy and talented.

Showed this video to a friend. She responded, "it's true with exception to Mary, the mother of Jesus".

Thank you for great presentation! Ive been thinking about one question. In the "bullied" mouse experiment epigenetics were not transmitted but in cherry blossom smell, the fear was transmitted to offspting due to epigenetics. Is that a contradiction that in some cases environmental quality gets passed in others not?

If for whatever reason molecular biology doesn't work out for Nessa Carey, she can surely do well as a stand-up comedian! Very entertaining and enlightening talk!

Brilliant talk, engaging presentation..... - i feel for the mice, though.....

This was so interesting . Thank you very much

Great video! I can imagine that practical living advice can come from epigenetics, like how i can change my own in a positive way. Any chance to get that?

Does anyone know if algorithms were used to define theoretical epigenetic research concepts individually and where to find the results? Im into pattern recognition.

All I want to do right now is eat strawberry laces and jelly tots.....on a serious note, this lecture was FASCINATING - thank you Nessa for your fabulous energy teaching this

🪄✨ Made with SummarizeYT ​0:49 - The human genome sequence was first released in 2001, causing a huge hoopla. ​2:03 - Epigenetic phenomena have been known for a long time but were not given much attention. ​3:00 - Laboratory mice with the same genetic background can have different weights due to epigenetic factors. ​5:01 - Gender in crocodiles is determined by the temperature at which the eggs develop, not genetics. ​6:01 - Different cell types in our body have the same DNA code but exhibit different characteristics. ​8:08 - Epigenetics plays a crucial role in gene expression and can be influenced by external factors. ​12:00 - Epigenetic modifications can switch genes on and off, leading to different gene expressions. ​14:00 - Epigenetic modifications can be compared to different flavors of jelly tots, introducing flexibility in gene expression. ​16:15 - Epigenetic modifications can also compact DNA, permanently switching off gene expression. ​17:27 - Epigenetic modifications can go wrong and contribute to diseases like cancer and diabetes. ​19:01 - Children who have experienced abuse or trauma in their childhood are more likely to develop chronic diseases later in life. ​20:07 - Epigenetics can influence what happens in organisms without altering the DNA sequence. ​20:42 - Baby rats that are loved and cared for by their mothers have low levels of stress hormones. ​22:03 - Epigenetic modifications in rats can be passed down from generation to generation. ​24:01 - Epigenetic information is necessary for mammalian reproduction. ​26:41 - Epigenetic changes can result in significant differences in physical characteristics, as seen in agouti mice. ​30:03 - Mice can learn to associate a smell with something negative, and this fear response can be passed on to their offspring. ​31:43 - Lamarck's theory of acquired characteristics is not entirely accurate, but epigenetic changes can be influenced by the environment. ​34:01 - Trauma experienced by male mice can be passed on to their offspring. ​35:05 - Epigenetic changes can affect the offspring's physical characteristics, as seen in the experiment with female mice. ​36:03 - Identical twins can have different outcomes due to epigenetic changes.

Always love a new RI video, always get annoyed about the huge difference between the sound level of the title credit and the lecture itself.

Her explanation about stress and childhood experiences is interesting. I was very fortunate because I had a pretty stable, happy childhood with a protective father who thought I was a piece of gold and a loving mother who was a great nurturer. Even though I was overweight and constantly bullied, I retained my happiness and confidence that has allowed me to be successful in my career and personal life. I am married to a great person, but have noticed that he is usually depressed and insecure. His sister has finally admitted that out of 6 siblings, he was given the least amount of attention and praise and was often criticized. This was needed information for me as his spouse because I can now understand why he rather that I remain overweight. When I lost most of my weight, my husband would exhibit jealousy and insecurity. He would retreat into his den, and not talk to me. Now that I have lost my mobility, my husband seems happy which I find hurtful, but with theory, I have learned that he feels empowered because he feels no one will find me attractive and he can now be the only person I can depend

We need more real scientist dedicated to discover and instructs and inform us broadly . Thank Madam

Would a babies/child’s dna receptors be affected/changed by a traumatic birth experience? Ie would a more ‘relaxed’, non stressfull/traumatic birth experience have a better outcome for a child later in Life?

Are the 8 proteins in the nucleus of the same composition in everyone, or are they widely differing?

fantastic - thank you so much for posting

How do you determine if a characteristic is truly determined epigenetically or if there is some other factor, like the chemicals given off by gut bacteria, or some changes triggered by viruses, or some other mechanism I can't think of just now?

It would be interesting to know what foods could turn on or turn off gene expression in humans and the outcome of the change.

so the dna is still the same, just the little "jelly" dots that attach to the dna that a person might develop while interacting with his environment? But what's the mechanism behind the epigenetic changes (my guess it's still the DNA that gives instructions to the protein to make the epigenetic changes)...I mean could epigenetic changes lead to the eventual creation of a new species? Thinking more ahead, how much can we augment our body through tweaking the expression of various genes, like would we be able to grow a new arm through epigenetics, or is that sort of mutation still dependent on the manipulation of DNA? You say that the little "jelly" dots, sorry I forget the exact term you used for those molecules, attach to the genes and affect their individual expression, but how many genes do we have, what are each gene's functionalities, how does each gene interact with each other, and what explains the difference between us and a chimp or a bird or something? God damn it get more research done lady! My back is hurting from watching all these Royal Institute videos laying on my bed at 1AM in California, and I also don't have a car to go to work tomorrow morning, and I think it'd be really nice if DNA technology can allow me to grow a pair of wings! (though the image might be a bit grotesque) so I can fly around to work and buy groceries or something...

There's one thing I am confused about. So if the histones are wrapped around our genes, and say you become a smoker (but no one in your family tree extending hundreds of years smoked) and the chemical tag is added to the histones to make that gene become 'expressed', does that mean that the 'smoker gene' is predetermined? In other words, will I have a 'smoking gene' by default that is turned off, but will only be turned on if I smoke?

Actually I wouldn't say it's a new field of biology but rather one we just found out about lol ... super interesting

So correct me if I(male) am having PTSD, OCD ( like traumatized male mouse in above mentioned ) get artificially inseminated into a healthy female the offspring produced would be devoid of PTSD, OCD ( traumatized condition). Is this applicable to humans has there been any research on it?

Links to the research studies mentioned?