Dr. E.J. Chichilnisky: How the Brain Works, Curing Blindness & How to Navigate a Career Path

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Andrew Huberman

Andrew Huberman

День тому

In this episode, my guest is Dr. E.J. Chichilnisky, Ph.D., a professor of neurosurgery and ophthalmology at Stanford University. He studies how we see and uses that information to build artificial eyes that restore vision to the blind.
We discuss how understanding the retina (the light-sensing brain tissue that lines the back of our eyes) is critical to knowing how our brain works more generally.
We discuss brain augmentation with biologically informed prostheses, robotics, and AI and what this means for medicine and humanity.
We also discuss E.J.’s unique journey into neuroscience and how changing fields multiple times, combined with some wandering, taught him how to guide his decision-making in all realms of life.
This episode ought to be of interest to anyone interested in learning how the brain works from a world-class neuroscientist, those interested in the future of brain therapeutics and people seeking inspiration and tools for navigating their own professional and life journey.
Thank you to our sponsors
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Dr. E.J. Chichilnisky
Academic profile: stanford.io/3TdtdIg
Publications: stanford.io/4adV0iM
Lab website: stan.md/49UpMNL
Chichilnisky Lab Make a Gift: stan.md/4cmqSns
Lab media: stan.md/4cgmIgH
Stanford Artificial Retina Project: stan.md/3IGydAl
Stanford Artificial Retina Project Make a Gift: stan.md/3ThSt0h
LinkedIn: / e-j-chichilnisky-97857429
X: / stanfordretina
Article & Other Resources
Donor Network West: www.donornetworkwest.org
NeuraLink: neuralink.com
National Eye Institute: www.nei.nih.gov
Huberman Lab Episodes Mentioned
Dr. Erich Jarvis: The Neuroscience of Speech, Language & Music: www.hubermanlab.com/episode/d...
People Mentioned
Krishna Shenoy: professor of engineering, Stanford: stanford.io/49Z9Rhw
Jaimie Henderson: professor of neurosurgery, Stanford: stanford.io/48Yl2Wb
Eddie Chang: professor of neurosurgery, UCSF: bit.ly/3SLsjmd
Eric Knudsen: professor of neurobiology, Stanford: stanford.io/48XgZcW
Robert G. Heath: psychiatrist, early brain stimulation research: bit.ly/3TAIaFP
Brian Wandell: professor of psychology, Stanford: stan.md/3TEgVtW
Markus Meister: professor of biology, Caltech: bit.ly/3x5iE2y
Timestamps
00:00:00 Dr. E.J. Chichilnisky
00:02:31 Sponsors: Eight Sleep, ROKA & BetterHelp
00:06:06 Vision & Brain; Retina
00:11:23 Retina & Visual Processing
00:18:37 Vision in Humans & Other Animals, Color
00:23:01 Studying the Human Retina
00:29:48 Sponsor: AG1
00:31:16 Cell Types
00:36:00 Determining Cell Function in Retina
00:43:39 Retinal Cell Types & Stimuli
00:49:27 Retinal Prostheses, Implants
01:00:25 Artificial Retina, Augmenting Vision
01:06:05 Sponsor: InsideTracker
01:07:12 Neuroengineering, Neuroaugmentation & Specificity
01:17:01 Building a Smart Device, AI
01:20:02 Neural Prosthesis, Paralysis; Specificity
01:25:21 Neurodegeneration; Adult Neuroplasticity; Implant Specificity
01:34:00 Career Journey, Music & Dance, Neuroscience
01:42:55 Self-Understanding, Coffee; Self-Love, Meditation & Yoga
01:47:50 Body Signals & Decisions; Beauty
01:57:49 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, UKposts Feedback, Momentous, Social Media, Neural Network Newsletter
#HubermanLab #Neuroscience #EyeHealth
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: www.hubermanlab.com/disclaimer

КОМЕНТАРІ: 305
@chrisisdunn
@chrisisdunn Місяць тому
This comment is for Huberman in general not necessarily this episode in particular. I just wanted to express the admiration and gratitude I have for this channel. Personally I experienced depression in my youth that was life threatening to say the least, I say that to illustrate how much of a change you’ve made to my life. Through years of therapy and changes to my health, many MANY of which were inspired by you, I am the happiest person I know. In face people come to be regularly asking for advice on mental and physical health and I recommend your work so much it’s become a bit of a joke in my circle how much I advertise for you. What’s more admirable to me is not that you have made vast improvements to my life and secondly to those around me, but how much of a change you have on the rest of the world. Mental and physical health is such a hard beast to conquer but it’s so important, probably the most important thing we will ever do. And you, Dr.Huberman, have done more to positively impact the world than any else I’ve ever seen. You share rigorously scientific information that is trust worthy, articulated in a way that makes sense, tools that are beyond useful and you do it for free and on such a vast scale. I cannot imagine a more fulfilling life than that and I hope to one day be just like you.
@TheCamilaM
@TheCamilaM Місяць тому
I would love an episode about dance and neuroscience! A hug to all fellow dancers, professionals or not!
@annmoses654
@annmoses654 Місяць тому
Yes! There is increasing research on movement and how it can affect mood, aging etc. Would love to see what Dr. Huberman reveals.
@pohkeee
@pohkeee Місяць тому
Interesting…to explore the benefits of enhanced skills of not only muscle memory, a fine tuned sense of timing… but also proprioception, the awareness of the body in space.
@user-mo2sg8mf5k
@user-mo2sg8mf5k Місяць тому
Dancing makes the regions of the brain responsible for dancing bigger. That’s my guess
@jessicasanchez5765
@jessicasanchez5765 Місяць тому
​@@annmoses654I would like to know how people can remember all those steps in order. To me, dancers have genius level memories!
@matusjurcik6974
@matusjurcik6974 Місяць тому
U can predict. Its cardio training plus sensory stymulus.
@belrapley4326
@belrapley4326 Місяць тому
Hi Dr Huberman I have retinitis pigmentosia I’m almost blind now in both eyes I have no retina and there is currently no cure for it at this stage but every day I appreciate I’m still here on this earth I live through joy and gratitude I learn to look at my obsticals through my inner strength Every day I live through adventure and love I laugh at myself a lot as I bump into things a lot but ahh well l can’t help it Last night I listened to your video I felt so many feelings for you I’m so proud of you and inspired from where you were as a child and all the work you put in your life to where you are today your story touched my heart and I felt sad for you when you were taken away from your family but as I know that where we find our strength from inner pain we find our inner strength I appreciate the work you do and I’m very grateful thank you so much for
@LaurieLaurie-sf3nc
@LaurieLaurie-sf3nc 9 днів тому
I pray I'm alive when EJ et al can bring eyesight back to the blind 🙏🏻
@mwd473
@mwd473 Місяць тому
I have watched a few of your podcasts on UKposts; the ones that grabbed my interest. I am 74 years old. The ones that I watched have, without question, improved the quality of my life. Many thanks for providing these opportunities.
@adrianagiraldo9315
@adrianagiraldo9315 Місяць тому
EJ just became one of my favorite neuroscientists 🙌🏽💜🙌🏽
@adrianagiraldo9315
@adrianagiraldo9315 Місяць тому
I love Costello and miss his snoring 😅😢🐶
@olgazavilohhina6854
@olgazavilohhina6854 Місяць тому
¡Hola Profe! Thank You for a beautiful conversation with such an insightful Guest. Our eyes are not only two pieces of our brain, but also windows of our soul. Thank You for all Your hard work and care for all of us.
@mr_savage4314
@mr_savage4314 Місяць тому
Hello Professor Huberman, I dont know if you can see this message, I am listening to your podcast since 2022, and they have helped me alot in fixing my unhealthy lifestyle. I would forever be grateful for that. Keep inspiring! Keep Helping! Regards
@Maggieiaconeta
@Maggieiaconeta Місяць тому
What I can say is just “Wow”, amazing episode Dr Huberman . I loved when your guest formulated you a question? Lot of passion and engagement ❤
@patriciapagan7461
@patriciapagan7461 Місяць тому
This is wonderful! My beautiful daughter has Retinitis Pigmentosa (CERKL) and is totally blind (except some dark/light). She gets around with a great guide dog and, in fact, works for an organization that gives the gift of these dogs to the blind and visually impaired, but oh, to think that one day, she will see me and look into my eyes again. See a sunrise, sunset, fireworks, stars, and all the beauty in the world. Thank you Drs Chichilnisky and Huberman. Its great to know that the research is moving forward.
@idaalavioon
@idaalavioon Місяць тому
We support you professor Huberman. Keep speaking your truth no matter what.
@tstatus1206
@tstatus1206 Місяць тому
my friend actually lost her vision to an auto immune disease 6 years ago and we pray it comes back one day. im practicing growing lionsmane and other medicinal mushrooms to hopefully help her vision return one day
@kylynoliver9260
@kylynoliver9260 Місяць тому
I'm 26 and I have MS I would love to chat with you!
@tstatus1206
@tstatus1206 Місяць тому
@@kylynoliver9260 ok
@marshad.9149
@marshad.9149 Місяць тому
Everyone should have a good friend like you ❤
@richiebailey8163
@richiebailey8163 Місяць тому
An episode on skin and skin health would be super informative. It’s the biggest organ and would be great to know the do’s and do not’s in how to take care of it
@markspencer352
@markspencer352 Місяць тому
would it not be COOL to have a class with these two teaching?!?!?!?
@jjuniper274
@jjuniper274 Місяць тому
These discussions just keep getting better. Thank you.
@starlasse
@starlasse Місяць тому
Really enjoyed this uplifting episode - science plus wisdom - Know thyself, be thyself, love thyself. And I have a new word to use more often…”behold” - you both have great energy and I loved it!! ❤️❤️
@shewong9767
@shewong9767 Місяць тому
It’s great to see how much Andrew and E.J. see eye to eye on this fascinating topic.
@jlcperu1
@jlcperu1 Місяць тому
Thank you Dr. Huberman for another amazing topic 👏👏👏👏👏
@user-jf8dk5nq6o
@user-jf8dk5nq6o Місяць тому
Thank you for having this brilliant guest! Listening to him was a true joy ! What an absolute gift!
@karenmcrobb3105
@karenmcrobb3105 6 днів тому
How cool is Dr EJ! Such sincerity and passion...what a mission he is on!
@suzanneshort72
@suzanneshort72 Місяць тому
Two friends, two scientists, two amazing humans. Thoroughly enjoyed this episode. I think back to the only science learning I had in high school - chemistry and biology. Neither exposure led me to believe I’d so enjoy listening to scientists riff!
@user-jf8dk5nq6o
@user-jf8dk5nq6o Місяць тому
I am so incredibly excited for this! I know I'm not the only one who's been waiting for the ophthalmology professor to teach us this! Woo hoo!
@shelleydiamond6468
@shelleydiamond6468 Місяць тому
Dr Chichilnisky is simply one of the coolest people on the planet. Not just for the science, but for the person he’s evolved to. Loved the story of his career & life evolution.
@FREEAGAIN432
@FREEAGAIN432 Місяць тому
wow, this cast was fantastic. Really love that he spoke about his history with music and dance, and in general how open minded and nuanced he is with his language. INSPIRING!! Thank you Andrew and E.J. Invaluable.
@gins8781
@gins8781 Місяць тому
Long before your guest said he performed music I saw his hands and thought, “What great hands for piano or guitar!” This interview made me rethink what to share with my neurologist. Since “the eyes are two parts of the brain”, having ocular migraines might be significant information for them to know.
@nigist0402
@nigist0402 Місяць тому
I'm inspired by you professor Huberman. I even tell my Dr that I've been following your podcast to listen to my body.❤ thanks for all the efforts.
@lynnnestor7985
@lynnnestor7985 Місяць тому
It takes Dr E.J. Into his body intuition + soul …just pure joy (+ power) for us to witness this humbling sincerity. Many, many brilliant thoughts would no doubt pass through his mind but he doesn’t need to attach to these as he knows thyself. A captivated Dr Huberman throughout the full exchange but culminating in an element of surprise of Dr E.J.s deep “awareness” (a great insight into evolving consciousness) of love ( + self compassion) was the apex for me to take away. Dr E.J.s mind body perspective will assists his colleagues + all listeners to “pause” in awe. His beautiful easeful breathing cadence gave him away😌🙏
@annmoses654
@annmoses654 Місяць тому
I'm going to need to listen to this conversation more than once.. so much to think about. It was beautiful to see your friendship.
@LynnevandenBergpgmod
@LynnevandenBergpgmod Місяць тому
great comment!the mutual admiration spread warmth throughout the conversation, a joy to witness and a ton of wisdom shared with a big dose of science
@BAInspire
@BAInspire Місяць тому
Absolutely fascinating! Dr. E.J. Chichilnisky's work on artificial eyes and his insights into the retina's role in our perception are groundbreaking. It's incredible how neuroscience can lead to such life-changing innovations, potentially restoring vision to the blind. The discussion on brain augmentation and its implications for the future of medicine and humanity opens up so many possibilities. Also, his unique career path is truly inspiring, reminding us of the importance of exploration and adaptability in both professional and personal growth. Thank you for sharing this enlightening conversation!
@mikewilliams1782
@mikewilliams1782 Місяць тому
I’ll listen to this soon, I heard about the hit piece and came to comment that I am here with 💎🙌🏼
@anothercrazyredone
@anothercrazyredone Місяць тому
I've been listening for a couple of years now I'd say... definitely a big fan. I've never felt the need to comment; I figure you get lots and probably most bases are covered. Near the end of this episode though, the more personal conversation between the two of you caught me. Yes, the facts and research being done by E.J. is fascinating and the science riveting.. but the interpersonal discussion/connection you shared about the experiences that only come occasionally, if we are lucky, or perhaps more often if we are in a place to be able to really be open to it... where exceptional beauty takes your breath away... Or meeting a person with such amazing energy that is so captivating and can make one feel so alive... or the feeling that comes when one just *knows* within that a path is the right one and the ease that brings... I appreciated that. It's something about the human connection. The richness. And you're right; I guess science cannot explain that. I helped me to feel more connected to you both as well as myself.. Thanks.
@adrianagiraldo9315
@adrianagiraldo9315 Місяць тому
What delightful, insightful, and humbling conversation. I can relate to what he shared about finding a meaningful way to make an impact to change people’s life for the better.💜🙌🏽🧠. All this as I keep debating on whether or not pursuing a PhD or keep doing what I am doing 😮
@babygiirl0931
@babygiirl0931 Місяць тому
My baby has CVI and a stage 4 brain bleed. Thank you for this podcast. ❤
@drosphiliamelanogaster3755
@drosphiliamelanogaster3755 Місяць тому
I love the part about personal developmental side of Dr. E.J. Chichilnisky. It's important to know we can move forward and still make a difference.
@waynegalvin4639
@waynegalvin4639 Місяць тому
Excellent show, hopefully all blindness can be eliminated in the coming decades!
@Katawitcher
@Katawitcher Місяць тому
Just wanted to express my gratitude to Dr Huberman. I listen to your podcast and will be listening and I hope your fans like me understand that mainstream media are there to destroy any person thinking different than they would like us to think. Totally behind you sir.
@masudaurunova4224
@masudaurunova4224 Місяць тому
Haven't seen more simple and precise explanations thank you❤
@user-hu9zy9tb4u
@user-hu9zy9tb4u Місяць тому
Dr Huberman, last year I read an article in The Times (UK) about your work generally and this podcast in particular. As someone with serious neurological issues (MS) and severe eye problems, some resulting from MS but some as a result of chronic uveitis. (go me and my interesting ailments), your work was of particular interest. Consequently I've tuned into your podcasts ever since . My dentist thanks you by the way (he says no to mouthwash too). But this episode got me really excited. Although the loss of sight in my left eye relates to atrophy in my optic nerve, this has been a very interesting episode. Knowing that there are clever people out there, working hard to understand how we 'see' and how we might be able to restore vision to the blind is mind blowing. Of all the health issues that affect me (and there are many) losing my sight in one eye has been devastating. Each day I'm thankful for my remaining sight and pray that it remains as long as possible. Thank you Dr E J Chichilnisky and huge thanks Dr Huberman - the work you do through this podcast means more than you can imagine.
@user-iz3kg4gv3j
@user-iz3kg4gv3j Місяць тому
One of my favorites. His work seems to come from such a beautiful place and intention. And Ashtanga! That practice demands from the depths. Thank you both so much!
@0dnamra1
@0dnamra1 Місяць тому
From Puerto Rico. We have watched your show from episode 0. We stand with you brother.
@edandtaramaluszczak1490
@edandtaramaluszczak1490 Місяць тому
Dr. Huberman- As always, thank you for making science interesting. I am a dedicated listener to your podcasts, and this particular episode really resonated with me. Dr. EJ's compassionate description of the tireless efforts of the dedicated team, along with his profound respect for the donors' invaluable contribution to science, truly struck a chord. If there was ever a convincing argument for becoming an organ donor, he certainly made it!
@prmft94123
@prmft94123 Місяць тому
What a beautiful concept: "Ease." So true. So beyond explanation. Thank you.
@scotchbarrel4429
@scotchbarrel4429 Місяць тому
Im half way thru, just wanna acknowledge how great it is to listen to experts who have mastery of the english language and can articulate clearly, so even dumbos like myself can absorb some of this complicated field. Love it Doc, well done, great gueat 👊😎
@GfnWiz
@GfnWiz Місяць тому
Truly amazing…retired military that specialized in TBI/PTSD. Amazing stories to share, I just need a direction. My brain is expanding again.
@GfnWiz
@GfnWiz Місяць тому
My new, ever changing mantra….Stop, Breathe and Behold
@sandragee2864
@sandragee2864 Місяць тому
Interesting interview. Suggestion: would you do a deep dive into hearing research? Just as important as vision is hearing. Hearing makes social connection possible. There is isolation and loneliness due to age related deafness. Loss of hearing is related to dementia. I think it also plays a role in early emotional development since there seems to be more behavioral disturbances in deaf children compared to blind children. Finally, keep up the good work! I now look forward to Mondays to listen to your UKposts channel.
@onespeedbjj3846
@onespeedbjj3846 Місяць тому
As somebody who has been dealing with a detached retina and massive complications from it in my right eye as well as a Chemist working in research. This was a really amazing podcast I don’t know how I haven’t heard of Dr. E.J C as much research I’ve done on the retina. Such an amazing guy doing amazing things. We don’t realize how important something as common to use as vision is until we face the possibility of loosing it. This guy and people like him give me hope for the future. I hope to one day be part of something as beneficial to humanity as this man.
@nda4591
@nda4591 Місяць тому
What a gem of a conversation! So enriching on many levels starting with the informative aspect ending by the inspiring journey shared. It’s beautiful to see two great scientists with no power complex, moved by their scientific curiosity and love of doing good science that gives back to the society. Thanks for sharing this great content!
@AznDudeIsOn
@AznDudeIsOn Місяць тому
EJ's insight into the retina is fantastic Love what EJ had to say about being at ease and know-be-love thyself
@angelvelik
@angelvelik Місяць тому
Amazing, so fascinating. Thank you so much for this conversation, and for pushing such wonderful science forward.
@Nirmaljikoirala
@Nirmaljikoirala Місяць тому
Dear Andrew Huberman, I have your recent podcasts and I really found them very knowledegable and productive. I'm a person with albinism - a syndrome causing body and hairs to be white and eyes to be not normal by birth. I sincerely request you to broadcast a podcast with an expert regarding albinism highlighting its causes, occurrence, and all related informations for safe life of albinos. I hope to see your podcast on it soon. ❤❤
@alegria4vida
@alegria4vida Місяць тому
Wow. I love so many things about this podcast episode.. and have a number of questions after listening! It ties together many aspects that have made this a powerful resource for me: the love for science, the cutting edge of science, understand ourselves as humans and also looking to what we can become/how we can grow, a strong spirit of curiosity and wonder, reminders and the pursuit to "know thy self", a deep passion for giving to the world, and coming back to simple and grounded techniques and tools... Finding this podcast is like finding the thing I always wanted to give but didn't imagine was possible. It is a huge inspiration. Questions: 1. I love how you highlight here and elsewhere that people don't always take the standard pathway to find where they thrive/have found a sense of purpose. Since discovering this podcast, I'm feeling a deep pull to question how I can get back to my love for science and research (I had this as a kid and fell in love with biology in my undergrad but went in [many] other directions). Are there ways to get involved with labs/research happening other than going back to university for post grad? Especially research involving things like brain-computer interfaces, dreams, fear, meditation, breath, states of consciousness... I know your premium channel supports a lot of research work done on humans, so are there ways to start working with those organizations? 2. It is mind blowing to think about how sight works - especially that it is all getting converted to electrical signals... I have often wondered about the science behind visual illusions and visual hallucinations. For example, I wonder why in states of meditation, if my eyes are open (gazing at a candle for instance), I start to see visual changes - there is a darkening of the room, features change that are not physically changing which stop if I break the state/focus... Hard to explain in words. 1. Could you explain how these types of experiences work especially given all the context here in this episode? 2. And more specifically for visuals that come with psychedelics, is that acting on the retina directly? Or is the drug creating a signal directly to the brain? It makes me wonder what would happen if you put the active substance of psilocybin for example directly on the retina.. I probably don't know enough about either to be suggesting that, but I'm fascinated what we would discover (and see!). 3. As to the cutting edge.. It is exciting to see the advancements in AI and neuroscience. I wonder about how incorporating machines into our brain/body might have second order effects and if/how we could get ahead of the curve to prevent negative impacts from the start. For example how could we have developed smart phones/wif/etc differently if we knew that the EMFs from phones can be detrimental to some aspects of our body? Is this something you think about? And if so, could you share some of your concerns and ideas and questions so that perhaps people in these areas of research and development can take more consideration along these line? How can we better ensure we design these types of machines/technologies with the future in mind? PS - I love how your podcast doesn't just focus on the information, but also the people. I love hearing how these scientists and successful/amazing people (yourself included) are interested in so many of the things I am interested in (yoga, meditation, exercise, love for tea/coffee, how to "know thy self", etc) and also struggle with so many of the things I do. I feel more connected to myself and others through this podcast. Thank you for creating that sense of togetherness. Thank you for your interest in humanity Dr Huberman!
@Altus45
@Altus45 Місяць тому
Please do know that all of us who followed you, and watches your videos we support you. ❤
@miladzangene5011
@miladzangene5011 Місяць тому
I'm watching every single video from beginning and taking note Thank you sir for your effort and HARD WORK I appreciate your hard work It would be great if you release some books your humble student From IRAN ❤❤❤❤❤
@oOZanlanOo
@oOZanlanOo Місяць тому
Technical Telepathy is possible for decades. Nice to see people waking up and talk about it.
@DocJon1
@DocJon1 Місяць тому
Thank you Andrew , can't wait to listen to this !!!❤
@jacobclausen5656
@jacobclausen5656 Місяць тому
I’m an optometry student and I couldn’t be more excited for an episode 🤓
@mico9406
@mico9406 Місяць тому
What a beautiful person Dr. Chichilnisky is... 💜 Great interview! Thank you 🙏🏼
@snasnusnaba3361
@snasnusnaba3361 Місяць тому
Such a good vibe. What an uplifting episode!
@csillatalamasz196
@csillatalamasz196 Місяць тому
So glad for the persistent Layman terms` explanation in your podcasts, much appreciated!
@douglasalmeidask8
@douglasalmeidask8 Місяць тому
Thank you for this conversation. The concept of ease mentioned at the end of the episode is just beautiful and it is going to for sure frame my vision of life in a different way. I'm in awe!
@marshad.9149
@marshad.9149 Місяць тому
Love the friendship interactions, & calling each other brother. ❤
@dameanvil
@dameanvil Місяць тому
01:50 🤔 Chichilnisky describes his unconventional career path, emphasizing the importance of exploring diverse interests and experiences. 09:11 🎯 Chichilnisky discusses the significance of focusing on the retina for understanding vision, highlighting the potential for engineering solutions to restore sight. 15:40 📸 Explanation of how the retina processes visual information, likening it to Photoshop filters or different movies, showcasing the complexity of human vision. 17:44 🦌 Comparison of human vision with other species, illustrating the unique features of the human neuro retina and its limitations in perceiving certain aspects of the visual world. 20:29 🌈 Humans perceive color based on three primary colors, while other animals can capture more wavelength information. 21:51 🦉 Rodents possess retinal cells sensitive to looming shadows, helping them avoid bird attacks, showcasing how different species have unique visual needs. 23:11 🧪 Research on retinal cells involves intensive experiments, especially when studying human retinas obtained from deceased donors, requiring swift action to preserve tissue viability. 26:15 🏥 Human retinas are obtained from organ donors shortly after death, allowing for crucial research into vision and retinal function. 27:26 🧠 Sophisticated electrophysiology equipment is used to study retinal ganglion cells, enabling simultaneous recording and stimulation to understand their electrical activity. 29:44 ⚡ Electrical stimulation of retinal cells is explored for potential vision restoration methods, demonstrating the intersection of research and practical applications. 31:22 🧬 Understanding retinal ganglion cell types is crucial, as they encode various features of the visual world, aiding in detecting motion, color, and other visual stimuli. 32:17 🧠 Cell types are fundamental in neuroscience, influencing our understanding of brain function, consciousness, and neural circuitry. 34:34 📊 Cell types in the retina are identified based on their function, morphology, gene expression, and electrical properties, essential for interpreting retinal signals accurately. 37:36 🎨 Visual stimuli used in experiments range from controlled patterns to random flickering images, allowing researchers to uncover responses from different retinal cell types. 40:47 🧠 The retina responds to transitions in the visual scene rather than static imagery, and studying naturalistic visual stimuli is crucial for understanding its function. 42:53 🤔 There are about 20 different cell types in the retina, but only seven are well-characterized, with another 15 still largely unknown, highlighting the ongoing mysteries in retinal research. 46:07 🧬 Recent breakthroughs have identified around 15 new cell types in the retina, each with unique properties and responses to visual stimuli, expanding our understanding of retinal circuitry. 51:41 🔬 Neuroengineering aims to restore vision by bypassing damaged photoreceptor cells and directly stimulating retinal ganglion cells, potentially offering solutions for vision restoration in conditions like macular degeneration and retinitis pigmentosa. 53:57 💡 Existing retinal implants lack sophistication and fail to replicate naturalistic vision due to their crude stimulation methods, highlighting the need for more advanced devices that consider the complex circuitry of the retina. 57:49 🛠 Incorporating scientific knowledge into neuroengineering efforts for vision restoration is crucial, as current retinal implants do not reflect decades of research on retinal function and cell types, highlighting the gap between research findings and practical applications. 01:00:21 🧠 Building a robotic retina or artificial retina could fundamentally change vision, enhancing sight or enabling new visual abilities. 01:04:46 🧬 Researching parallel visual pathways in the retina could lead to the development of devices for streaming diverse visual information simultaneously to enhance human vision. 01:05:39 🤖 The artificial retina implant, designed to restore vision, can also serve as a research tool to explore how the brain receives and processes visual information, potentially leading to new visual sensations and abilities. 01:09:55 🔬 Neuroengineering aims to augment neural function through precise stimulation of brain regions, starting with the retina due to its well-understood structure and cell types. 01:17:15 💡 Developing adaptive electronics that can understand and interact with neural circuits, possibly utilizing AI and machine learning, is crucial for effective neural modulation and augmentation. 01:19:07 🧠 Chichilnisky discusses the concept of a "smart device" in neuroengineering, emphasizing the importance of precise stimulation and recording. 01:20:02 💡 Electric shock therapy, though often viewed as barbaric, can yield impressive clinical outcomes in treating depression by inducing a non-specific release of neurotransmitters. 01:21:38 🩺 Impressive advancements in neural prostheses outside the visual system, such as restoring movement in paralyzed individuals or facilitating communication through brain-computer interfaces, are underway. 01:25:18 🧬 Viewing the neural retina as part of the brain offers diagnostic insights into neurodegenerative diseases like Alzheimer's, hinting at the potential of retinal imaging for early detection. 01:27:10 🧠 Chichilnisky discusses the plasticity of the brain and the challenges of adapting to enhanced sensory inputs, advocating for an incremental approach to neural augmentation. 01:36:44 🤔 Chichilnisky shares his non-linear journey through multiple PhD programs before finding his passion in neuroscience, highlighting the importance of perseverance and finding the right mentor. 01:39:29 🐦 Dance may have evolutionary roots in language; Chichilnisky shares insights from Eric Jarvis' research on bird vocalization and dancing. 01:40:13 🔍 Exploring diverse interests led Chichilnisky to develop expertise in retinal research, laying the foundation for his work in developing retinal implants to restore vision. 01:41:37 🌱 Chichilnisky emphasizes the importance of self-awareness, acknowledging that his career path feels accidental but aligns with his mission to advance vision restoration technology. 01:45:02 🧠 Reflecting on personal development, Chichilnisky shares the aphorism "know thyself, be thyself, love thyself" and discusses the significance of understanding and accepting oneself. 01:53:18 🌟 Chichilnisky shares the awe-inspiring experience of examining the human retina, highlighting the intersection of scientific curiosity, beauty, and purpose in his work. 01:55:05 🌐 Chichilnisky's research aims to not only understand the nervous system but also to apply this knowledge towards developing technologies that serve humanity, expanding the possibilities for human potential. 01:56:27 🌍 Chichilnisky emphasizes his commitment to using his research to benefit humanity, both in treating diseases and enhancing human experience. 01:56:56 🧭 Chichilnisky reflects on his unconventional career path, highlighting the importance of intuition and personal preference in guiding one's journey.
@Johnramboandcigar
@Johnramboandcigar Місяць тому
Hello Andrew, I've been listening to your podcast through spotify for the recent days at work and I really appreciate your work. You asked for suggestions for future episodes and since I've been diagnosed with essential tremor and you have alot of knowledge in that area, could you cover tremors and if it's possible to treat them to make the effect lighter, in one of your future episodes?
@emilymkaye
@emilymkaye Місяць тому
Very inspiring to hear Dr. E.J. Chichilnisky's story and how he got to where he is !! Thank you :)
@DanielSlim-yq1hs
@DanielSlim-yq1hs Місяць тому
You spoke about building smart devices. So why not implant and AI chip behind the retina of a living person, and see how the self fire by his day to day life. Forever grateful for The constant treasure trove of inspiration!
@valoriebroderick
@valoriebroderick Місяць тому
Awww, I love seeing such seasoned scientists melt into big softies. I like seeing that side of sciencey people. Sometimes science comes off as very cold. But it's nice to see the sense of awe and beauty that also comes with a deep understanding of it. And I completely understand getting emotional about dogs. Dogs are amazing. Having my dog snoring next to me makes all the difference in the world in a way that I really don't know how to explain.
@cesarhurtado4871
@cesarhurtado4871 Місяць тому
Dr Huberman, first and foremost I wanted to thank you for the awesome content you share and the respect and professionalism you bring to your audience. I had a unique and bizarre (for me) moment in military basic training: We were always told to hold military bearing, one of those aspects is to stand at parade rest when speaking to a drill sergeant. In parade rest you are not allowed to do any kind of movement that isn't your mouth when you speak. There was an instance where I ran into a drill sergeant and they were asking me about my whereabouts and why, I'm standing at parade rest (feet shoulder width apart, hands behind my back), but I'm bobbing my head in the direction I'm going and the drill sergeant immediately yells at me and tells me to stop moving my head, and like magic my brain went completely blank. I froze. Eventually I recovered my thoughts and was able to explain myself. Would love to hear the mechanisms behind this phenomena.
@nikan2269
@nikan2269 Місяць тому
Full support to Andrew and all he does 🙏🏼
@PariSA991
@PariSA991 Місяць тому
Doc, in one of your podcasts you mentioned the reason you’re wearing a black shirt is that you don’t wanna distract ur audiences, while watching your podcast I just noticed that I can focus perfectly when the camera goes closer to take a close shot of your eyes!🤣 Big beautiful blue eyes, our lovely doctor💪🏿💪🏿
@selfcraftedking4881
@selfcraftedking4881 Місяць тому
Andrew, thank you for being a science hero to us all ❤ I plan on being at your next live event!
@LindsayGeinert
@LindsayGeinert Місяць тому
What an insightful & sweet conversation between two good friends! Sounds to me like E.J. makes decisions using his third eye ;)
@bhvnraju8493
@bhvnraju8493 Місяць тому
Amazing stuff, So engaging and wow feeling not only for sharing neuroscience and retinal insights but also making us to understand. With great Respect Namaste to BOTH of you 🙏🙏
@jackfbn
@jackfbn Місяць тому
Another phenomenally engaging and and enlightening session. Thank you, doctors!
@fangyushen4210
@fangyushen4210 Місяць тому
I wish we could have Noam Chomsky to talk about language learning or other scholars to talk about language acquisition and aphasia🙏
@VideoWill
@VideoWill Місяць тому
This will be epic!!!
@lucretiasulimay1968
@lucretiasulimay1968 Місяць тому
Great conversation as usual!! I'm learning things that I would not even think about if it wasn't for you,Dr Huberman, thank you!!
@briansprock2248
@briansprock2248 Місяць тому
I went to a course in Germany once called Seeing without eyes. I did not fully breakthrough, other attendees did. Still I was amazed by my personal progress. There is plenty info on youtube on this subject and how to learn it
@ApplesOranges123
@ApplesOranges123 Місяць тому
Keep up the great and inspiring work Andrew.
@nadagranger7939
@nadagranger7939 Місяць тому
How fascinating science is , thank you for this episode ❤
@user-cb8hb4oq7g
@user-cb8hb4oq7g Місяць тому
I’m blind in my right eye because of a retina detachment 12 years ago. 12 surgeries later they couldn’t save my sight. This conversation gives me hope! If you need test subjects for trials sign me up. 🙏🏻
@lenkabosma5629
@lenkabosma5629 Місяць тому
You make me feel calm. Thank you
@endobiff
@endobiff Місяць тому
Another amazing interview. Could you interview Pavel Tsatsouline at some point in the future?
@hubermanlab
@hubermanlab Місяць тому
Yes!
@Arnieman1993
@Arnieman1993 Місяць тому
Hi Andrew, Little thing: In the shownotes it says: "mediation and yoga", it has to be "meditation and yoga". Just listened to check.
@anubhavsaikia6187
@anubhavsaikia6187 Місяць тому
Hello professor huberman . As an audience we would love an episode with jim kwik and talk about all the various superpowers of the brain.
@dianechilds1857
@dianechilds1857 Місяць тому
Wonderful interview!! Deep science is where I experience “God.” And it sounds like Dr. Chichilnisky does too. A transcendent experience. Thank you so much!
@ClaireAdamian
@ClaireAdamian Місяць тому
Much appreciated for this amazing video
@sarasprague762
@sarasprague762 Місяць тому
I really enjoyed this podcast, mostly for the real bromance at the end. It is wonderful to hear/see this kind of authentic and tender companionship. Thank you. Also-I think that Irvin Yalom or The Gottmans would be super guests on your show, and as a mental health counselor, I’d like to ask you to reconsider using *certain* sponsors who do not protect the privacy of their clients…I know you use most of the products that sponsor your program-and maybe you use this one, too. It’s different though….this might be really interesting as a topic: how has the landscape of MH treatment changed since the pandemic. Because, boy howdy, as a therapist, I’m just over here with my mind blown!
@LCarefortheworld
@LCarefortheworld Місяць тому
Thank you, Dr. Andew for another fantastic interview. Please cure for dry eyes. 🙏
@Sofinews
@Sofinews Місяць тому
The best
@Sofinews
@Sofinews Місяць тому
Keep up the excellent work, skateboarder!
@GirlLearnsWellness
@GirlLearnsWellness Місяць тому
This is so interesting! Thanks for sharing 😊
@Giovanni-zj8vs
@Giovanni-zj8vs Місяць тому
Hey AH, thank you for everything. Would love a video regarding the science behind decision fatigue, decision making and why we make decisions the way we do.
@nancyberman5357
@nancyberman5357 Місяць тому
Thanks for this from a vision pioneer.
@bil9uun
@bil9uun Місяць тому
Hi Mr. Huberman. We would love an episode on acne. Such a controversial topic that needs your help!
@stephaniebest9428
@stephaniebest9428 Місяць тому
I went 3 years with half of my retina detached. I went to my regular eye doctor 15 times or more and a neurologist because of the loss of my eyesight and hearing my loss was suddenly. They didn’t catch it so I had no choice but to find a new I eye doctor and he knew right away something was wrong. My eyesight is now ok but my left eye doesn’t work without my right eye now. I had to have two cataract surgeries my photoreceptors are damaged and I have scar tissue where my retina was reattached. It was a horrible experience. I had no idea what the retina’s function was.
@ebebecker
@ebebecker Місяць тому
@hubermanlab I really admire your work, Namaste to you always! However, this one I don’t have strong enough words to thank you, I just want to hug you both and say thank you over and over. Also, it makes me wish to be loved as much as you have Castelo… I so wish he knew how luck he IS, even though or even if he no longer physically here. Much love to you both ❤❤❤
@lunarteswisewoman
@lunarteswisewoman Місяць тому
Fascinating work, ❤2❤
@The-ghost911
@The-ghost911 Місяць тому
Can you make an episode about the frequency that is going into our body when we meet new people
@vexowmc580
@vexowmc580 Місяць тому
andrew huberman. the PSSD and anhedonia community NEED you. please 🙏
@benjaminkutler7772
@benjaminkutler7772 Місяць тому
Is there anyway you can upload these videos to Spotify too the way Lex does? I think that’s an awesome feature. Love the podcast!
@hali6260
@hali6260 Місяць тому
Robot eyes??!! I'm strapped in and ready to listen.
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