The "Sheenis" joke got me. Charlie just took blow after blow, not like he wasn't used to that lifestyle already

Seth struggling to tell Tyson's "S" joke is the best part xD

Seth MacFarlane is honestly one of the most talented voice actors ever. It amazing how he is able to change his impressions so quickly

When roasting Charlie Sheen is just telling the truth 😂

All I can hear is Brian Griffin roasting everyone.🤣

Tyson had a fairly intelligent joke about Homer that I never would have expected. Well played!

Seth is not actually a person, he's the first attempt at turning a cartoon character into a real boy

I love how Seth’s impression of Gilbert Gottfried just sounded like a Wilem Dafoe Green Goblin impression

He's a guy that has beaten everyone he has come against except the letter S😭

Seth is so amazing. He surely knows how to take jokes and laugh at himself. He also knows how to be mean. It's cute.

Seth doesn't get enough credit. Freaking talented human being he is

I dont think anyone can beat Seth with roast jokes, after all he has been doing that pretty much nonstop on the family guy for a years.

I could see the fear and uncertainty in Seths eyes when he was telling that last joke about Tyson. He legit regretted writing that the second he started saying it

I’m convinced Seth did this just so he could roast them to their face.

Idk why but Gilbert Gottfried yelling his lines at us always comforts me

Charlie Sheen was laughing because he’s like “yeah, that’s me”

"Hottest woman of 2002" that joke gets more potent over time

Charlie Sheen mentioning all his surgeries had me rolling

I love Seth's casual and conversational delivery of his jokes.

Can’t stop imagining Brian talking 😂

Seth is one of those really talented people who can do it all.

Seth is a national treasure. That Tyson letter S joke was hilarious

Seth Mcfarlane and Ricky Gervais the ultimate/underrated collaboration . They speak the truth because its necessary.

Seth MacFarlane is essentially the Eminem of celebrity roasts and adult animation. No one gets at him and goes unpunished

He absolutely obliterated every single person who made more than one joke against him 😂😂

Sending people to roast seth mcfarland was like sending children to anakin skywalker.

Seeing Beth Chapman in the crowd really hit me in the feels. Rest in Peace, Beth.

"And I always seem to look like someone just squirted lemon juice in my eyes" 🤣 😂 that Gilbert Gottfried impression always gets me

I was not expecting Gilbert. He recently passed about a week ago… honestly that first second of hearing his voice made me sad. What a legend. We all loved you. You will always be a legend.

most of these were not comebacks; they're people who went after Seth followed by what Seth said about them first.

4:55 Seth’s Gilbert impression sound like Willem DaFoe’s green goblin

The best Seth roast in my opinion usually goes over people's heads... "Anthony Jeselnik act combines the excitement of standing there with the thrill of saying words. You know him best from me saying his name right now."

Who in his right mind dares roast Seth MacFarlane? 😂 He roasts people for a living.

MacFarlane is a comic genius. I would have loved to have seen some Jeff Ross and MacFarlane back and forths.

He delivered all the jokes calmly except when he told the letter S joke. Even seth can't hold his laugh 😂

Ik it’s bad timing and all but Seth’s Gilbert Godfrey impression got me cracking up 😂

Seth laughing as he tells the Tyson joke. Partly because it’s funny , and partly out of fear. “Everyone has a lisp joke till they get punched in the mouth”.

Technically his “comebacks” where delivered before the other person

Seth Macfarlane is so funny he can take any joke I wish the rest of the world could still do that

Seth Mcfarlane is hands down one of the best MC's at a roast!

Seth trying to roast to Gilbert Gottfried really just sounds like green goblin judging his own appearance

What an absolute treasure to have Patrice on one of these roasts, one of the greatest comics of his generations, so deep!

His actual respect and laughter is so actually wholesome to his own insults

See, Seth, You're not the only person who got by by taking ideas from Homer -Mike Tyson 😂

The fact Seth worked for Hanna Barbera , makes Patrice's joke much funnier than it should be 🤣

I just realized that Gilbert is the freaking parrot from Aladdin

Its not often that I laugh out loud. But that Patrice Cinema joke had me rolling.

I wish Seth would've gotten Patrice on family guy, they're an unlikely match up that would undoubtedly be a hit

Seth MacFarlanes Gilbert Gottfried impression is actually an INCREDIBLE Willem Dafoe impression

Brian griffin roasting everyone for 9 minutes and 57 seconds

You could here Seth’s fear when it was time to roast Mike! Hahahah

Seth MacFarlane is hands down my all time favorite producer, actor/voice actor! I love everything he does... I haven't disliked a single thing this guy touches. I have nothing but the utmost respect and love for him. If I could meet one actor or famous person it would be Seth 👍 👌 I own every episode of family guy as well as American dad. The Orville is amazing as well. Season three comes out on my bday 🎂 🥳 this guy takes a lot of pain away and helps people escape, truly underrated.... we need to enjoy him while we have him!!

Charlie Sheen looks older than 46 bruh

Seth has already made a career out of roasting these people. For him, this was nothing more than a rerun.

This man is a legend I don't know why everyone underestimates him.

"rosa parks fought" joke had me dead, the shock factory and delivery and excellence of that joke

Can we talk about how Seth looks like a 8 year old Italian kid at a wedding.

The look on Seth's face saying "Sheen-is" was epic!

I love the way he can take it as well as deal it out...he sits & laughs when he is being roasted, then when it's his turn, claps back. Doesn't throw a wobbly, just calmly dispatches any opponent :)

Rare occasion where the comebacks were better than the attacks… brilliant work

I'm still laughing at some of the harshest roast from seth.

Seth destroyed Hasselhoff, and i love it

I'm dying from laughing. The Gilbert Gottfried bit was too funny

Love how all these comedians use the vilest, filthiest terms to attack Seth and he comes back with grace and class and buries them. 😁

Isn’t this everyone else’s revenge since Seth roasted first for the Charlie sheen roast?

Seth is a beast when he roasts!

The last joke about Mike is the best out of all of it 😂

Roasts, especially the old school ones really show the importance of needing to able to take criticism and having a thick skin. You have to take shots at people and do it on the spot/little time to prepare, and not accidentally say something too serious/cross a line. It's really a skill to do this successfully

The Iliad one really got me 🤣🤣🤣

The fact that I'm watching this today, the day Gilbert died, I wasn't expecting to get hit with his roast. RIP.

I have never seen Brian Griffin roast so many characters at once

After Seth roasted Tyson he should've said and now if you'll excuse me I'm gonna run as fast as I can to my car.🤣🤣👍 Tyson got him with that homer joke though

Still love that Mike Tyson called Iliad a poet and not a poem lol makes me laugh bc u know a writer just wrote that joke and he got it confused bc its so out of his wheelhouse

The fact that I now know that Charlie is only 6 yrs older than me gives me soooo much hope for where I am in life at 40!!!!!

even in his grave people will be nervous at roasting tyson.. thats a real legend 🙌

I love how out of nowhere amongst the people it shows hulk hogan there.

Patrice O'Neal: Seth MacFarlane doesn't have a partner. Butch Hartman: Am I a joke to you?

Seth is so charming. The sparkle in his eyes, the smile. Funny guy.

these people should get a medal of honour to come up on stage and roast Seth MacFarlane

These roasts are so savage. I love it.

Watching this to remember what it was like to tell jokes and not get slapped.

That joke by Tyson is elite. Referencing the Iliad and stealing from homer😂😂

Gilbert’s Simpsons joke was the best.

Mike tyson is a vicious boxer who knocks people out permanently, and can still manage to have a sense of humor and a personality. Will smith slapped chris rock for a haircut comment. Now let that sink in…

Actually Seth already have his own "Barbera" in Alex Bornstein form.

Seth is always gonna be my favorite comedic mind, also RIP Gilbert Gottfried

This video is just incredible all of some of the best celebrities together roasting each other

Poor Charlie got totally bulldozed flat by Seth. (Yes, with S, not with M. That's another story.)

I'd be forever grateful to Seth for family guy.

Yo Seth is a legend on come back burns 🔥.

4:13 when your custom character is in a cutscene

I wish people were easier on him. His movies got a laugh out of every few minutes it wasn’t appreciated enough. The Orville seems to be where his inspiration is these days which is great. Family guy is a bit lacking but he’s still doing amazing work on American dad he’s going all out for those voiced even if he’s not so much writing anymore. I wish he were appreciated to make more work

Seth might be one of the only people to Hassle the Hoff without punishment

Seeing Beth and Dog in the crowd

Seth is extremely talented! Love seeing him on the roasts 🔥

Seth’s Gilbert Gottfried impression sounds like Willem Dafoe’s green goblin 😂

I love Seth MacFarlane.

gottfried in here with the real take away. RIP you absolute legend.

His name isn’t Charlie Sheen it’s Señor Drugs😭😭

Love Seth he's brilliant