Shoutout to those of us who had to rewind the video because we lost focus and zoned out!

Felt the need to add this as well: No doctor (at least in my country) is going to take their time and explain all of this to their patient. Thank you for putting out this for the public.

The irony of a two hour podcast discussing adhd stimulants .

0:23: 🧠 Stimulants for ADHD treatment target specific brain networks involved in attention and focus. 10:06: ✨ Stimulant drugs used to treat ADHD improve symptoms by enhancing the prefrontal cortex's ability to suppress and enhance the activity of different brain networks. 20:17: ⚡ Adderall is a potent sympathomimetic drug that increases the activity of dopamine and norepinephrine in the brain, resulting in increased motivation, focus, and alertness. 31:16: 💊 Different drugs like Adderall, Vyvanse, and Ritalin increase dopamine and norepinephrine levels in the brain to improve focus and attention. 49:04: ✅ ADHD is a complex condition that involves challenges in focusing on various tasks, and the use of stimulant medications like Adderall and Ritalin can help increase dopamine and norepinephrine levels to reduce distractions and improve focus. 52:08: 🧠 The use of stimulant drugs like Adderall and Ritalin in the treatment of ADHD is not just about increasing neural activity, but about tuning the amount of dopamine and norepinephrine in specific brain networks to achieve the right balance of activation and synchronization. 1:03:08: 💊 Treatment of ADHD involves a careful diagnostic evaluation, consideration of both pharmacological and behavioral treatments, and monitoring of nutritional and supplementation aspects. 1:13:39: 🧪 The use of drugs like Adderall, Ritalin, and Vyvanse for ADHD treatment does not appear to negatively impact height or growth, but long-term elevation of sympathetic nervous system activity may carry some cardiovascular risk. 1:23:24: ⚠ The timing of cortisol release is key, as late day elevations in cortisol are a strong correlate of depressive symptoms. 1:33:53: ⚠ ADHD drugs, such as Adderall and Vyvanse, have a higher likelihood of inducing psychosis in individuals with a predisposition, but the overall incidence of psychosis is still fairly low. 1:44:06: 💊 Different drugs are used to treat ADHD, with methylphenidate being the most studied, followed by modafinil and guanfacine. 1:54:23: 🧠 Guanfacine is a medication used to treat ADHD by stimulating the alpha 2A system and activating pathways that dampen down the sympathetic nervous system. Recap by Tammy AI

Sometimes the timing Huberman has to upload things I suddenly want to know is pretty scary.

Thanks for the black background and the lack of decor as well as black shirt. Perfect. No distraction

Who else is watching this at 2x⏩ speed while also reading the comments and looking for the next video to watch? 😅

I just discovered this man, i live is Spain, im just a regular guy, electrician, and waiter before, but i can notice this man is great, full of knowledge, and he speaks so clearly and straight, i start to follow him, and at the same time practice my poor english language, congratulations to you Doctor, youre amazing 👍👍👍

Huge service to the ADHD community. You summarise so much neurobiology into precise illuminated explanations. Your advocacy for ADHD in the popular podcast sphere is essential! 🙏

Would be cool to also touch on or hear about the dangers of undiagnosed or untreated ADHD. How those stack up against the negatives of these medications. Great video!

I'm a psychiatric nurse practitioner specializing in the treatment of children and adolescents. This podcast episode was far more informative and immediately applicable than any lecture series or graduate-level course I have thus far attended. I am not surprised, as Dr. Huberman is a phenomenal teacher, but I am exceptionally grateful for all the easy-to-understand examples he puts forth in this episode that I can utilize starting today to help patients and their families better understand this disorder and available treatment options. Thank you, Dr. H!

Here are the key highlights from the discussion: • Stimulants like Adderall, Ritalin, and Vyvanse are commonly prescribed to treat ADHD. They work by increasing neurotransmitters like dopamine and norepinephrine. Adderall, Ritalin, and Vyvanse are stimulant medications commonly prescribed to treat attention deficit hyperactivity disorder (ADHD). They work by increasing the neurotransmitters dopamine and norepinephrine in the brain. Dopamine helps treat the core symptoms of ADHD in a few ways: Noise reduction: By boosting dopamine levels, stimulants can help suppress distracting thoughts, stimuli, and urges. This helps "reduce noise" in the brain and improve focus. Signal amplification: Norepinephrine helps amplify relevant signals that the individual needs to pay attention to. This improves the brain's ability to detect important stimuli and direct attention appropriately. Neuroplasticity: Increased dopamine and norepinephrine levels promote neuroplasticity, which helps strengthen and "train" the brain circuits involved in attention, focus and impulse control. This can provide lasting benefits even after medication use ends. So in essence, stimulants work by optimizing the balance of neurotransmitters in the brain to alleviate the core symptoms of ADHD: inattention, hyperactivity and impulsivity. The "calming" effects come from the brain's increased ability to filter out irrelevant stimuli and focus attention where needed. This is a simplified overview of the basic mechanisms of how stimulants work to treat ADHD. Let me know if you have any other questions! • Increased dopamine helps reduce "noise" in the brain by suppressing distracting thoughts and stimuli. Increased norepinephrine helps amplify relevant signals to improve focus. Here are some additional details on how dopamine and norepinephrine contribute to improved focus in ADHD: Dopamine: • Dopamine increases the signal-to-noise ratio in the brain. It helps tune out irrelevant background thoughts, stimuli, and internal sensations. This "reduces noise" to improve focus. • The prefrontal cortex uses dopamine to inhibit distracting activity in other parts of the brain, like the default mode network. This allows for more targeted attention. • Higher dopamine levels allow the brain to shift attention among relevant stimuli or tasks more easily. This supports aspects of executive function like task switching. So in general, dopamine helps suppress distractors to boost the "signal" the individual needs to focus on. Norepinephrine: • Norepinephrine activates the salience network in the brain, which detects important stimuli that demand attention. • It amplifies relevant signals at synapses to strengthen communication between neural circuits involved in focus and attention. • Norepinephrine is thought to help sustain attention on important tasks over time by optimizing cognitive performance. Together, dopamine and norepinephrine work in complementary ways: • Dopamine helps reduce noise and distractors, while norepinephrine boosts the salience of relevant signals to improve focus. • The right balance of these neurotransmitters, as achieved with stimulant medications, helps individuals with ADHD better direct and maintain their attention on important tasks and information. • The dosage needs to be individualized and closely monitored. Too high of a dose can cause side effects like anxiety, psychosis, and cardiac issues. Dosage: • There is tremendous individual variation in the optimal dosage of ADHD stimulants for different people. • Some people require very low doses (e.g. 2.5 - 5 mg of Adderall), while others need much higher doses (up to 100+ mg for Vyvanse). • The general approach is to start with the lowest effective dose and increase gradually as needed based on response and side effects. • Weight-based dosing is used as a rough guideline, but actual dosage requirements vary widely and are determined by testing different doses. Side effects of high doses: • Too high of a stimulant dose can cause side effects like: - Anxiety - Insomnia - Irritability - Increased blood pressure and heart rate - Psychotic symptoms (in susceptible individuals) • High doses can also lead to addiction, abuse potential and drug seeking behaviors. • Peripheral effects like suppressed appetite, weight loss, headaches and tics may also occur at excessive doses. • Some individuals become tolerant to higher doses over time, requiring even higher amounts to achieve the same benefits. This increases risk of side effects. Key takeaways: • The optimal stimulant dose for ADHD treatment is the lowest effective amount that: 1. Significantly improves symptoms 2. Is well tolerated 3. Does not cause unwanted side effects • Close monitoring of dose, response and side effects by a psychiatrist is critical, especially as doses change over time. • Individualizing dosage based on a patient's needs, biology and characteristics can maximize benefits while minimizing risks. Hope this expanded explanation of dosage and side effects provides useful additional context! Let me know if you have any other questions. • Taking stimulants during development can help "train" the brain circuits involved in focus and attention. But they must be used judiciously to avoid long-term issues. Benefits of early treatment: • Taking stimulant medications during childhood and adolescence can promote neuroplasticity in the brain circuits involved in focus and attention. • This "training" effect can help strengthen these circuits and establish better functioning even after medication use ends. • Early treatment of ADHD with stimulants has been linked to: - Improved executive function and cognitive performance - Better school outcomes - Higher rates of high school and college graduation - Less severe ADHD symptoms over the long term Potential risks of early use: • Excessively high or prolonged doses of stimulants during development could potentially: - Impact growth and development - Disrupt the endocrine system - Increase risk of substance abuse or addiction - Lead to behavioral or sleep problems • However, properly monitored and appropriately dosed stimulant treatment during childhood does not appear to significantly increase these risks. Key considerations for early treatment: • Monitoring growth, sleep, hormones, mood and behavior is important when using stimulants during development. • Starting at the lowest effective dose and gradually titrating upward based on response and side effects can help maximize benefits while minimizing risks. • Periodic "drug holidays" were originally recommended to allow the brain to normalize, though this practice has fallen out of favor recently. • Combining medication with behavioral therapies and lifestyle modifications may produce the best long-term outcomes. • Stimulant treatment during development should generally continue as long as it significantly improves symptoms and functioning without major side effects. In summary, while stimulants carry some risks during development, properly monitored and appropriately dosed treatment appears to provide neuroplasticity benefits that can last well beyond medication use - especially when combined with behavioral interventions. However, judicious and individualized use is essential to minimize potential harms. • There are risks of abuse and addiction with stimulants, but properly prescribed and monitored treatment for ADHD may actually reduce those risks compared to untreated ADHD. • Other options like Modafinil, Armodafinil, and Guanfacine are also used off-label to treat ADHD. They work through different mechanisms. • Combining drug treatments with behavioral interventions tends to be the most effective approach for managing ADHD. • Regular check-ins with a qualified psychiatrist are important to determine the right medications, dosages, and monitoring of side effects over time. In summary, stimulants and other drugs do have a role to play in treating ADHD when used properly. But careful consideration, dosage adjustment, and combination with non-drug treatments are critical to minimize risks and maximize benefits.

Great episode!! My partner has ADHD and wasn't diagnosed properly until he was 28-29 years old because his parents had a stigma against the medication when he was a child. He managed to get through and excel in his masters, but only through self-medicating with caffeine, smoking and alcohol which was detrimental to his physical health. Now he's doing his PhD with medication, he's off the drinking and smoking, exercising more, eating better, and it is a complete world of difference for him.

I was an adult in my 30s when I was diagnosed. I was referred to a psychiatrist for depression. I waited 6 months for my appointment and when I went I thought I knew exactly what was going to happen. They were going to say I'm depressed and prescribe anti-depressants and recommend therapy. At the end of that first appointment, when my psychiatrist said "I think you have ADHD", I laughed out loud in his face. It was the LAST thing I was expecting to hear. I could not believe it. Being medically treated for ADHD changed my life. It was like I was experiencing the world for the first time. A fog I had never seen before was lifted off of me. I have been very lucky in my ADHD journey in that I have not experienced the many hurdles and horror stories I've heard from other people with ADHD, but I have certainly had difficulties. Getting the diagnosis was the easiest part. For a time my prescription was 80mg Vyvanse daily. One time I couldn't get into my regular physicians office for a refill, because I left it to the last minute, so I went to a drop in clinic. And despite living in a country with socialized healthcare where health records have standardized access to all providers (the physician could verify my prescription history and diagnosis), this physician would not prescribe me the 80mg dose that I was currently on. To justify this decision, he brought out this little promotional card made by Vyvanse, and showed me where it said 70mg was the highest recommended daily dose. So he prescribed my 70mg. He didn't need to show me the promotional card because I knew the real reason. He risked being audited by his college if he refilled my prescription at the dose I was on. For the first three years I had to physically go into my physicians office every single month for my prescription. I was a clinical researcher in my 30s, multiple university degrees, no legal or substance abuse history, and for 3 years they treated me like the primary risk of my condition was drug accountability. Now I am nearly 40 and I have been granted the comfort of a physician refill for 3 months at a time. I confronted my physician about this on my last visit. I said that I am going to have ADHD for the rest of my life. Are you really going to have me come into this office every 3 months when I'm 80? Yes. The answer was yes. I have an American friend with ADHD, and he recently told me that he is required to submit a urine test, every month, before his provider will issue a prescription. He was told this was to make sure he was taking the full dose. But we all know the real reasons. It's unconscionable. Being diagnosed with ADHD has improved my life, but being treated like a drug dealer for no other reason than complying with treatment for my condition has challenged me.

I was actually diagnosed with ADHD few years ago. Also suffered severe depression and mental disorder. Not until my wife recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 6 years totally clean. Never thought I would be saying this about mushrooms.

I finally found a provider who actually listened to me and what I’d been struggling with my whole life, I had all the “potential” but never met up to it… I was called lazy among many other things. I couldn’t complete tasks and attempting college was an impossible task for me. My doctor encouraged me to get testing done and sure enough… adhd… it was hard at first grieving all the perceived wasted time I didn’t know or beat myself up over and over feeling like a constant failure. My doctor and I have worked to find a great combination of prescriptions that have completely turned my life around. I’m way more productive, I don’t miss things at work, I have a greater desire to exceed at my career. I have completely reframed my internal negative beliefs about myself and I’m able to feel accomplished when I complete things that used to be the biggest mountain to climb. I really enjoy digging into the science and understanding of my diagnosis and I really enjoyed this video. Thank you so much for providing this content. Side note, where are my fellow adhd folks that listened to this on 2x speed and multitasked so we wouldn’t lose interest 😂😂

Im on Vyvance 70mg, prescribed in my 30's after a lifelong time of untreated ADHD. Its been a life saver and changed my life incredibly.

Simply next level and inspirational! Articulate and easy to comprehend!

Really can't overstate how much this man has improved my life.

Thank you so much for this in depth review. I was diagnosed with ADD(ADHD) in second grade. I tried different medications over the years. Ritalin made me want to hurt my parents and Adderall gave me short term psychosis, even on a low dose. I have found other tools over the years to help me cope with my ADHD instead and personally respond really well to just a little caffeine, diet, exercise and sleep. My thoughts are with anyone who deals with this. You are not stupid your brain just works differently than others. 💙

As someone diagnosed with ADHD, I really appreciate this special! I got distracted about 5 mins in though so no idea what the actual content is. Sure its really good

I have been extensively researching ADHD for 4 years after (finally) being diagnosed at 38 yr old. Inattentive ADHD in the female population is just now getting the attention it deserves. To hear the latest and greatest research is so helpful as it helps me understand the why behind the what and helps me be my own advocate with my doctors. Thank you for this amazing and valuable content!!

Thank you, Andrew. I am 57 and was diagnosed in June this year. I'm a retired teacher and always suspected I hd add due to my experience with students with add as well as all the PD I've received on the topic. The diagnosis and resulting treatment has absolutely changed my life. Beyond quieting the chatter in my head and improving my executive function, it has completely eliminated my sugar cravings. It'd truly been incredible. Thank you for this lecture.

I would love more content on ADHD. There is so much confusion out there. Thanks for all that you do Andrew!

I'm 34 and have severe ADHD. Started taking Vyvanse this year and it has drastically changed my life for the better when it comes to my focus and career. No more constant fatigue and inability to focus. Now I can harness the good parts of ADHD without some of the crippling downsides.

Would love to hear an episode on the short and long term effects of SNRI/SSRI to manage mental health conditions

Andrew, you're incredibly generous. Sharing knowledge on these subjects is so precious.

Dexamphetamine has been a life changer for me. I'm in my 4th year of being diagnosed in my early 40's with ADHD. I'm so much more stable and able to cope with the challenges that life throws at me.

I take Vyvanse for ADHD but also for Binge Eating Disorder. It’s the only thing that completely helps me to control my impulses and not binge. It’s not about the appetite suppressant effect of the meds but the ability to be able to choose better and to not seek dopamine in food. Thanks for this video!

Thanks so much Andrew for the deep dive into ADHD and associated treatments. I always see a high level of integrity and impartiality in your work. Appreciated!

As a provider who diagnoses and prescribes these medications, thank you, I’ll be sharing this video with my patients. This is such a wealth of knowledge.

Hey Andrew, your podcast is amazing! I was diagnosed with ADHD in my mid-forties. I did stimulants to a problematic degree when I was young (not the kind you get a prescription for). The cravings were always there, even after I hadn't touched anything like that for decades. Then, after my diagnosis, I started taking Concerta. My cravings have been gone since. I think I was trying to do for myself what Concerta does for me but without the actual tools. This is such good information and something that so many people should hear

As a Huberman groupie I am eager to hear this one. I was diagnosed with ADD at age 47 twenty-five years ago and it was life-changing. I have been taking Ritalin ever since. I hope I can listen with an open mind.

This video is too long for my ADHD brain 😂

Thanks so much for putting this content out there. I was put on ADD meds about 20 years ago and have seen many psychiatrists and have tried to go off medication many times unsuccessfully. The medication still helps me manage daily life and especially with focus at work, but it also taxes my system frequently and can impact my relationships and ability to wind down and relax at home due to the hyper focus state it causes. I'd love if you could do a podcast that goes into more detail on strategies for helping support the brain and particularly nervous system if you have been on ADD meds for a long time and want to get off or taper down. I also think there are a lot of women out there on these meds wondering what is the best thing to do when they get pregnant and want to breastfeed. It's a HUGE topic that I could not find very information or guidance around other than just stop your meds, which I felt could be very dangerous for some people.

It’s such a privilege to access such extensive information from a Stanford professor in the comfort of my home. Thank you, @hubermanlab for producing these amazing lectures. Guys, it costs $6K per QUARTER to audit (sit in on) classes at Stanford… and almost $80K per year when enrolled for credit. And we are getting this for free. Amazing stuff…. Just amazing. Thank you!

Would really like you to make a follow up to this episode with alternative ways to treat ADHD with exercise, diet, supplementation. Thank you.

You are doing a service that will not be forgotten! My grandkids thank you Dr. Huberman

This is exactly the information I have been seeking. These podcasts have been a godsend after what my family experienced last year.

This is one I had requested, thank you so much for taking requests and taking the time to research and record this information. You and your podcast has taught me so much.

Concerta has been a lifechanger for me after 28 years of fighting myself for every drop of motivation. ADHD-PI used to be called ADD, so if people misconstrue it with hyperactivity, that's why!

I wish I had this information when my son was younger! My son is 18yrs old now, freshman in college and has been on Vyvanse since he was around 8yrs old. He says he doesn't feel like he needs to take it all the time. Makes sense after you explained how the brain is trained when on the meds. Thank you for the wonderful information/education, priceless for a parent like me.

Andrew, you have absolutely unique ability to convey the most difficult topic with "regular" words and structure, thank you!

The high dosage segment is actually very comforting to me. I've been afraid of bumping up my dose, just because I was afraid of the side effects, but knowing that as long as the psychiatrist approves, it should be safe, that is making me feel better about taking that step.

As someone with narcolepsy, this video was of equal interest for me as someone with ADHD. Thanks alot for the video!

Dr H. You’re a good man and your dedication to educating the public is much appreciated. God bless you.

Re: Tardive Dyskinesia:...I have developed this condition from long term use of Adderall and/or SSRIs. For those unfamiliar with the movement disorder, common symptoms are involuntary writhing movements of the tongue and mouth, which my M.D. says cannot be controlled. It is commonly known that older antipsychotic medications result in t.d.; however, whether due to the pharmaceutical companies not wanting it acknowledged, or for whatever reason, there is little awareness and focus on this resulting condition; be aware. Thank you for another fascinating lecture, Dr. Huberman; you are such an effective communicator.

Awesome content as always! Can you please make an episode on neurodivergence and autistic spectrum? I think it might be really interesting!

This was BY FAR the best explanation I have come across of ADHD. The concerns I have were addressed concisely and east to understand.Thank you for making science easy for those of us who sometimes just can’t “get” it. ❤

This is hands down the best video on ADHD and associated meds that I have seen on UKposts. Most videos either go so high level that I don’t learn anything new, or they fear monger about meds. I just started Adderall and was taking Atemoxetine before that, and it’s very helpful to understand what’s happening. I am happy to finally feel the “quiet” in my brain after a lifetime of thinking about everything all at once without being able to control it. Before medicine, I even got to the point where I was sleepy by noon every day and used to sneak home to take naps. I have suffered from years of having to work on weekends or nights to catch up. I was binging out of control because I couldn’t control my impulses. Finally medication is helping. And yes - I do exercise and try to eat right, and use behavioral therapy, but it wasn’t enough. A combo of all of these plus meds has helped me so much.

I have a BS in Biology, MEd in Education, worked in schools for 20 years. Also I have been being treated for Adult ADHD for 10 years. I have NEVER come across this information before. At the beginning when speaking of the Prefrontal Cortex and thinking back to good Ol' Phineas Gage, my whole understanding of my condition changed. Thank you. You Sir are changing people's lives.

Best video on ADHD and most thorough explanation of drug effects, the first time I hear about lasting benefits of drugs on connections in neurons

THANK YOU!!! for such an amazing podcast on ADHD medication. It was so well done. I am a parent of an ADHD kid and had so much shame about putting my kid on medication. It is such a journey and so refreshing to have such good scientific explanation about medication. It has really saved my kid's childhood experience especially in school. A few notes to add...my kid had to go through many different medications before finding one that worked and then every few years we had to make a change. This can be a hard journey. Guanfacine was prescribed to my kid to help with RSD, Rejection Sensitive Dysphoria, a common ADHD issue. She took it from about age 9 to 15. She just got off of Guanfacine. It was so needed and helped, but she is now mature enough to be able to deal with hard situations. When she was younger she was so sensitive that any critical feedback /bullying etc. she would lose it and not be able to function. It is nice to look at medication as temporary and that there is a path to getting off of it. She is still on Vyvanse but, again since she has matured, and working with her doctors can do a lower dose in the summer and also takes days off without significate side affects. I can see her as an adult only needing some focus meds like Vyvanse when needed. Additionally it has made me think more clearly about other medications like Zoloft for anxiety. While anxiety meds were not part of this podcast, it provided a nice framework to think about medications as temporary (even if it is for years), people change and it is good to think of most medication as something that is only needed during certain stages of life. My kid will likely only need until she is in her 20's and she can choose to get off of them if she wants. I am so thankful for medication options. These medications truly improved the quality of life for my kid and our family. THANK YOU so much for this episode and creating a positive environment to share an often sensitive subject.

Absolutely incredible. Thank you so much. I was recently diagnosed with combined version and have been researching and asking my doctors all sorts of questions, and here I find this video that literally breaks down EVERYTHING I wanted to know. Thank you so much for this.

thank you for taking the time to make this. we appreciate you.

Not sure if this was covered in previous episodes but would like to learn about comorbidities such as ADHD and Asperger's. Great podcast. You have helped so many people all over the world. And in the most understandable and relatable way. Thank you.

Would you also cover another non-stimulant for ADHD, Atomoxetine, please? Thank you, Prof Huberman, for this informative video!

I was misdiagnosed with ADHD and prescribed adderall for 20 years. A brain scan showed that it’s actually PTSD, severe depression, and anxiety. My ADHD symptoms are being caused by my mood, not damage to my prefrontal cortex. Willing to bet this is the case in many other ADHD diagnoses, especially those in their 30’s and 40’s being told they have it for the first time.

Such an informative episode especially the focus (no pun intended) on kids. I have an 8 yr old recently diagnosed & the truth is ADHD runs so incredibly deep & impossible for people to understand if they are not dealing with it themselves either personally or with a child. Your podcasts on this topic specifically, shines a little more light onto the empathy everyone should have on neurodiverse kids (& their parents) & how important it is to have a society support these kids more. Thank you Andrew.

You've quickly rose to the top as far as leading person we "ADHDers" listen to, to better understand our disorder and better take care of ourselves.

This was incredibly educational and I enjoyed learning about the medication I take. I have horrible ADHD and am prescribed Vyvanse. It helps immensely and I don’t know what I would do without my medication. Thank you Andrew for helping me understand how my medication works. 😁

I normally don't sit through 2 hour informative talk... but you got my attention... and I have experienced much of what you described. Thank you very much.

Thank you for choosing to discuss this topic. I feel lost in Narnia some more often than not times when wrapping my head remotely twords understanding these. Very good video

I was diagnosed with ADHD in my 30s and currently use 50mg Vyvanse, It's been a life saver but I've never used any other medications. I also suspect I'm one of the ADHD members whose on the spectrum but there's very little information about the overlap. Thanks for all you're work Dr.

I really appreciate this episode. Thank you❤️. I’m diagnosed with ADHD and wouldn’t wish it on anyone but I’m not looking for sympathies or attention.😊 I’m always trying to ignore “negative” reporting on ADHD but it’s sometimes unavoidable. I don’t understand why it’s still so common to claim that ADHD isn’t “real”? I’ve heard several doctors claim that ADHD isn’t a real thing! I rarely tell anyone that I have ADHD, unless I’m in a situation where it’s relevant. As a result, I often hear people saying they have occasional ADHD (despite no diagnosis) or that “everyone” has ADHD. In other words, people with a diagnosis must be faking or imagining things? With this in mind, it’s super frustrating that patients aren’t offered brain scans. If I understand correctly, it’s possible to detect or “see” ADHD? If so, why isn’t imaging offered as part of a diagnosis? This would serve the needs of patients AND hopefully stop misinformation about ADHD as something fake or imaginary. This might not seem like a big deal. I shouldn’t let other people’s opinions affect me, but they do. I can’t wait til the day that ADHD diagnostic tools improve, because it makes me feel incredibly invalidated when people say it’s not real despite the very real and negative consequences ADHD has had on my life.

this is incredibly helpful for someone who has taken vyvanse for about eight years. thanks so much for the great breakdown

an individual with great knowledge benevolent and charitable, he is willing to share his wisdom and teach people.

Dr. Huberman thank you. I, too, am interested in the relationship between ADHD, Autism, Asbergers, etc. Are there bright lines between each diagnosis? I, ask because my soon-to-be eighteen year old son--who takes vyvance--has never received a clear diagnosis. He's been treated by the who's who of specialists at UCI and USC for thirteen years. He was initially diagnosed with a condition known as DAMP symdrome, which, as I understand it means his central nervous system matures differently than neurotypical kids. An episode on 'spectrum' disorders would be great!

Please can you interview an expert on perimenopause and menopause. An interview with Dr Christopher Gardner on nutrition would be fantastic. Very interested to hear you interview a chiropractic expert. Thank you for all your amazing podcasts.

Huberman is EXCELLENT. By far the best I’ve ever seen/heard.

My intellect and obsessive interest in my own ADHD experience thank you for all this priceless content

Thank You. I can’t begin to express the amount of Joy that fills my heart for all the kids You have given the fighting chance to function in life. Truly Grateful.

Thank you for your service for ADHD kids + parents everywhere who have been scrambling to understand how this all fits! So grateful - and know what questions I'll be bringing to my kiddos next psychiatry appointment. Thanks Dr H, I hope you know how much of a positive impact your podcast has on so many!

Thank you for this and all the meticulous work you have put in so far.

I was on adderall for about 12 years. Before hand I was a very hard worker. During I was a circus level performance type worker. Once off of them, I’ve never had the energy to work again. My body is completely depleted of all energy. But I sure was hyper focused and rose to great success on it.

Would like to see a comparison of Amphetmaine/Ritalin vs. Caffiene vs. Nicotine in terms of affected neurotransmitters etc.. , also the effects/dangers of using the above in tandem?

Could you add a a full episode about narcolepsy and Idiopathic hypersomnia as an extention to this?

Just started on Adderall a week ago. Your videos have been very helpful understanding it all. Thank you

Great video, Dr. Huberman, love your channel. I’m diagnosed ADHD and have been prescribed atomoxetine (Strattera) as I did not tolerate very well the more common stimulant meds you covered here. If you ever produce a third video on ADHD, I would love to hear your take on Strattera. Thanks so much for making this video.

Wow!! What timing, diagnosed with ADHD with a too specialist at the age of 40 about 2 years ago and on the verge of losing a lot of things close to me because of it. What amazing timing, thank you for taking the time to put out so much information on a subject matter than many people are struggling with. Thank you 😊

This is a huge benefit to the ADHD community out there. I would love additional guidance on supplementation for ADHD - it seems as though there has been a huge proliferation of products out there being marketed as beneficial, but it's hard to access guidance on whether or not they really would benefit me, or how to tailor supplementation to my needs.

I almost quit university during the second year. I was diagnosed with ADHD that year and started on vyvanse. I am now wrapping up my graduate studies and getting a PhD.........life saver.

Great episode. Thanks for explaining the mechanisms of those drugs and also the dosage problems! In my experience people with ADHD tend to react diffrently to stimulants. A friend of mine with severe adult ADHD took methylphenidate for the first time, after taking it she got very calm and slept for three hours.

Just wanted to note that, thankful for not only the detail and focus that went into a video like this, also the tips created to better present myself. The descriptions to many of the medical finding are “digestible” and are placed together with relevant subsidiary explanations and analogies. The nonverbal cues seen were a great testament to a great speaker to keen learner. Thank you again. ✌🏾❤😊

I only saw 30% and understood only part of your presentation, but the fact that you have zero dislikes is a testament to the quality of your research and review. You present in such a rational way that it does us nervous/anxious ADHD types such a service when trying to understand ourselves. A warm thank you.

I'm an adult who has been prescribed Adderall in my 30s and it has changed my life in ways that are hard to talk about without expressing all my gratitude that it exists. I lived my entire life paycheck to paycheck, moved around the country, worked 25+ different jobs, started and dropped out of school 3 times, failed to graduate high school, and had a self destructive addiction to alcohol. Within 3 months of getting prescribed Adderall, I got a full month ahead on my bills for the first time in my life, stuck religiously to a budget, went to the dentist for the first time in 10 years, improved my diet, picked back up with a workout regiment focused on overall longevity and health, and got to work self studying to be a web developer. I have lived life in a tangled mess all my life, and for the first time I have confidence in my ability to make my dreams come true. I was even able to cut my dose back down by half after about 6 months because my sleep, diet/nutrition, and exercise became so much better, and I developed helpful habits that allow me to be more focused and take care of my life better. It's disheartening sometimes to see so much resistance to Adderall in popular culture, from people who want to sound smart and want to appear like they care and are looking out for others who want Adderall to be more difficult to obtain and more difficult to make. It's been nothing short of a miracle for me and for so many others and some people want to inhibit access, yet we allow for the sale of poison in a drinkable can or bottle at a grocery store. Poison that is implicated everyday in homicides, drunk driving, personal accidents, domestic abuse, bodily self harm, poor health, impaired judgement, with ZERO health benefits for ZERO people. This is insanity

This is probably the more informative video I've seen! Super helpful.

Huberman would learn more from Erowid at this point. Being obsessed with studies and ignoring real world, ground level experience is a massive blind spot.

I was diagnosed with adhd and prescribed adderal at age 7. I have had a long history of addiction, lashing out, being “zombied”. Then since I couldn’t sleep at night I was given seroquil to SLEEP! I refuse to give my children ANY drug. Much less a controlled substance!

I appreciate you so much for this. The dosage range is crazy. I too am in the high 200s with weight and take 2.5 mg, 2 times a day. Anything more than 10 per day has made me have panic attacks and anger issues when it wears off. We range so much, but adderall has been life changing for me. It’s helped me stop binging, it’s helped me make better, more rational decisions, stick with jobs, stick with school, etc. I wish my parents had explored ADHD as a reason for all my issues as a child. I definitely always had it but found out at 26 years old.

Literally, just crying saying I don’t know the right thing to do. I don’t know if I should take medication or not I don’t wanna negatively affect my brain chemistry further, and I wish I was praying for the right advice and boom this video. God bless you thank you so much I really trust you with all of my heart.

This made be feel better. I have extreme ADHD and BP II. The ADHD meds stopped the noise in my head and the racing thoughts whereas before, I could not function

Took Adderall and Ritalin for years to treat my ADD and the symptoms were unfortunately worse than the actual condition itself. Sweating, sleeplessness, weight loss, and extreme mood swings were all my symptoms. I switched to healthy eating and exercise instead 👍🏻

I wonder why vyvanse makes me feel so sad or emotionless ,but it's so effective .I got diagnosed at 29 after so much struggle maintaining a job ,yet I feel it really had long term effects on me even though I don't take them anymore. It might be behavioral changes just because I saw new possibilities and my inner values and goals changed .but I do things that I would never even try ,3 years ago. for example It would be nearly impossible for me to listen to this podcast in one sitting .I think my whole personality changed in almost 3 years. right now not only things are easier but I challenge myself to do things that are harder for me.

Thanks Huberman for this episode! I was diagnosed with ADHD around 2nd grade, and was put on Ritalin for a little while. Later in high school I was given Dexedrine. I quit Dexedrine and nicotine around the same time during my third year of college (20 plus years ago). I quit both of those substances after a major mental health episode, and managed to stay off of them, but I've never considered what was going on in my brain until I came across this episode (as well as Huberman's recent appearance on This American Life). Quitting these substances also coincided with discovering my passion for climbing. I always say climbing saved my life, and now I'm getting curious about the dopamine and other chemicals may have played a role in that. Hopefully we can connect some time, and thanks for your work. Peace, Luke Mehall Author: American Climber and The Desert Publisher: The Climbing Zine Host: Dirtbag State of Mind podcast

The Grand Master of Neurobiology! 🙌🙌Such a detailed and an informative Episode! Thanks truly!

I thought I knew what I needed on ADHD, seems not. Thanks for that. Topics I'd like to see visited : -Supplementation - right now, I find that my semi-regular intake of NAC (unsure yet if L-Tyrosine can do the same) and L-Theanine is giving me one of my best mental states in year, even more than Ritalin. Regular electrolytes are also a must. -Stopping medication - what to expect, tips to succeed, things to accept or not, daily life tips -Exploring the various aspects affecting sleep for an ADHD mind - thinking for example of racing minds, different sleep schedules, that people can sleep less or more for the same results... -Exploring combos of ADHD and various health conditions (and they can make it even more difficult to decipher, such as deafness)

48:00-49:00 Best description of the core problem ADHD people face.

Was diagnosed ADD at the age of 41 half a year ago. And I was also working as a sozial worker with Kids who have ADHD. In the Education - we did not learn anything about ADHD. Within the sozial media there are tons of people talking about ADHD but not many are more than oppinions, personal experienence or short and not based on any scientific data but more just on like wikipedia, youtube or chatgpt. So I realy want to thank you for your effort! I got good informations, and good learnings from this one.

I wrote my first published essay on the short/long term effects of Adderall on adolescence for treatment of ADD/ADHD.... This is something I wanna hear all the more now.