How Placebo Effects Work to Change Our Biology & Psychology

День тому

In this episode, I discuss placebo and belief and mindset effects - all of which exert a powerful and real influence on our biology and psychology. I discuss how your beliefs and expectation that a certain outcome will occur after taking a substance (or any intervention cause genuine changes in brain and bodily function. I discuss how placebos can change neurotransmitter and hormone release, pain levels, whether the stress response is beneficial or detrimental and more. I also explain how placebo effects can work with traditional drug or behavioral treatments to help improve health outcomes and why some people are more susceptible to placebo effects. By the end of the episode, listeners will understand the placebo effect, how it works, and how beliefs and mindsets can be leveraged toward mental health, physical health, and performance goals.
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Journal Articles
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease: bit.ly/3IrhjWc
Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses: bit.ly/49TSlKY
Impact of brand or generic labeling on medication effectiveness and side effects: bit.ly/3IkUWSn
DEMONSTRATION TO MEDICAL STUDENTS OF PLACEBO RESPONSES AND NON-DRUG FACTORS: bit.ly/3IofHws
Effect of capsule colour and order of administration of hypnotic treatments: bit.ly/3TiZG1k
Effect of colour of drugs: systematic review of perceived effect of drugs and of their effectiveness: bit.ly/3P4vF2G
Do medical devices have enhanced placebo effects?: bit.ly/3P4vJPY
Placebo Effects in Oncology: bit.ly/3TkNOMc
Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma: bit.ly/3T4Kfsf
Nicotine-related beliefs induce dose-dependent responses in the human brain: go.nature.com/3V15yNM
Mind over milkshakes: Mindsets, not just nutrients, determine ghrelin response: bit.ly/42ZKnhe
Mind-Set Matters: Exercise and the Placebo Effect: bit.ly/3IkV7Nx
A central master driver of psychosocial stress responses in the rat: bit.ly/3uJSBgU
Huberman Lab Episodes Mentioned
Nicotine's Effects on the Brain & Body & How to Quit Smoking or Vaping: www.hubermanlab.com/episode/n...
Dr. Alia Crum: Science of Mindsets for Health & Performance: www.hubermanlab.com/episode/d...
People Mentioned
Ivan Pavlov: physiologist, developed the conditioned reflex concept: www.nobelprize.org/prizes/med...
Ted Kaptchuk: Harvard, professor of medicine, studies placebo effects: ghsm.hms.harvard.edu/faculty-...
Alia Crum: Stanford, professor of psychology, studies mindset and belief effects: profiles.stanford.edu/alia-crum
Timestamps
00:00:00 Placebo Effects
00:02:40 Sponsors: Eight Sleep, AeroPress & Levels
00:07:24 Placebo, Nocebo vs. Belief Effect, Prefrontal Cortex
00:14:03 Dopamine, Placebo & Parkinson’s Disease; Placebo Controls
00:21:36 Hormone Release & Placebo Effect, Paired Associations
00:28:52 Conditioning Effect & Insulin; Pavlovian Response
00:32:50 Sponsor: AG1
00:34:17 Context & Expectations; Placebo Effect & Brain
00:40:51 Cancer, Mind-Body Practices; Placebo Effects & Limits
00:44:54 Asthma, Specificity & Placebo Effects
00:48:01 Sponsor: InsideTracker
00:49:03 Nicotine & Dose-Dependent Placebo Effects
00:55:31 Placebo Effects vs. Belief Effects, Food & Mindset
01:01:02 Exercise & Belief Effects
01:04:08 Placebo Effect, Brain & Stress Response
01:11:18 Individual Variation, Genetics & Placebo Effect
01:16:11 Zero-Cost Support, Spotify & Apple Reviews, UKposts Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
#HubermanLab #Science #Placebo
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: www.hubermanlab.com/disclaimer

КОМЕНТАРІ: 523

@enieslobby2182 2 місяці тому

Hey Andrew Huberman. I am a 14 year old. I have been watching you since 2 years. Just wanted to say thank you for all the invaluable information you give for free. ❤

@hubermanlab 2 місяці тому

Thank you for your interest in science!

@AnoneemusNoename 2 місяці тому

@@hubermanlab Can we get and episode on the relationships between all the sh*t, like contaminates and additives in everything we touch, eat, drink and breathe and how it relates to autoimmune diseases, various cancers, degenerative brain illnesses etc. sometime? I'm talking like all the organophosphates, xenoestrogens/microplastics, flouride, artificial flavours, preservatives, cellulose, hydrogenated seed oils, off-gassing from plastics and building materials like the formaldehyde in OSB sheathing, skin and hair products, sun block, various forms of radiation (radio, microwave, xrays) etc. I'm curious if the general consensus is the cumulative micro-exposure to all these things adds up to lead to all this stuff and what the most crucial things are to clear this stuff from the body and counteract its effects are. Essential amino acids, antioxidants, vitamins, TRT(?) etc. A supplement episode would be good too (i was gonna add it but i figured it could probably be it's own thing given how many there are and all the different ways they are extracted and stuff). I just wanna know what ones are worth taking as far as effects and bioavailability are concerned and what is a waste of time and money and why. The internet is full of BS and marketing hype so any kind of "this will most likely lead to tangible benefits over time" vs, "this is nigh useless and/or even harmful" would be greatly appreciated.

@Sridarsh 2 місяці тому

W lil bro, good luck to you brodie

@kalebgriffin1360 2 місяці тому

Big W having access to this so young is unreal

@kalebgriffin1360 2 місяці тому

Enies lobby is a W aswell

@jrodartec 2 місяці тому

My mom grew up in a family with little to no money and shared the house with a lot of siblings. Her father would buy m&ms, separate them by color, put each color in a fancy jar, and label it properly with their respective "medical properties", such as "Painkillers" for red ones and "Sleep pills" for blue ones. I grew up listening my mom insist on how effective those "pills" were, and laughing at her. Now, decades later, Mr. Huberman teaches me on the effects of color, labels and beliefs on placebo, and I find myself thinking: "My grandpa was a true genius. Made medicine out of sugar, and healed his family despite having little to no money at all." - Thank you Andrew! You make me humbler every day.

@springpena9873 2 місяці тому

What an amazing story!

@jrodartec 2 місяці тому

@@springpena9873 thank you!

@narellehinds2276 2 місяці тому

Hi Andrew I was a heavy drinker and addicted to seroquel. Since watching your podcasts I haven't touched any in 3 months. Amazing don't even feel like it. A big Thank you to you my life is really changing. I can't thank you enough

@balkibartokomous 2 місяці тому

This video itself is a placebo that made me feel better about all the other placebos I know I do.

@Shelly-cp7gj Місяць тому

Sweet haha, love this.

@hugomarx1324 2 місяці тому

Sorry for my English, I had severe Anhedonia after I quit my job. The job caused my mental breakdown and I had no other option but to resign. I couldn't sleep at night and it worsened my mental state. The ability to not fall asleep is like torture. You feel like screaming and going mad. It caused me to become paranoid and I thought I was becoming schizophrenic. I had no feeling or any emotions. It's like my soul died inside. No feeling, no pleasure. Only thing i felt was extreme agitation and that's when I decided to put on my running shoes and I ran 5km. It didn't really improve my mood but i consistently jogged every day and I gradually got my feeling back. I believe the sun exposure played a massive part in my healing. First thing every morning i went to the beach and swam in cold water. That brought me back to life. Why? Because it fixed my sleep. I believe the most important thing when depressed is to fix your sleep and daily sunlight, cold exposure, cardio exercises like running, hiking or breathing exercises does improve your sleep rapidly and that's the road to recovery right there. I highly recommend Wim Hof ,David Goggins, Alan Watts and Dr Hubberman if you feel paranoid or depressed.

@TheVirtualBomb 2 місяці тому

Good for you, glad you’re doing better! I heard people say that when you’re feeling mentally numb, do things that will force you to feel things externally. So like you said, cold water exposure, sunlight exposure, running and activities that will connect the mind to the body. I think a lot of people don’t do this because we’re told when you’re stressed you’re dealing with mental problems. Of course, the mental work needs to be done but can’t forget how much physical work matters too

@mariacolucci6958 2 місяці тому

Thank you for opening up and sharing your experience, I'm glad that you're feeling better! Sending lots of love and prayers your way 💖

@hugomarx1324 2 місяці тому

@@mariacolucci6958 thanks 😊 🙏

@leopepi834 2 місяці тому

Thanks for opening up man, I got similar problems. Shit is tough. We're in this together. Stay strong everyone!

@TheCamilaM 2 місяці тому

Alan Watts is a great author!!

@nikkiorourke3712 2 місяці тому

My sister in law has MS and has just had it confirmed that she has moved to the progressive form of the disease. It's so hard to see her feel so hopeless (and my brother). I have tried to research but as a lay person it is so difficult to know which is the trust worthy information. We are in the uk and although we are so lucky to have the NHS they can't offer or recommend the wide range of treatments that are available privately and around the world. it would be beyond amazing if you felt that an episode on this condition might be of interest to more of your audience. I completely understand you must get inundated with requests, but I'm feeling a little useless too so thought it was worth a try. Thank you

@mpt1992 2 місяці тому

Andrew. Top 0.1% fan according to Spotify here! Love your work. Regular listener since the beginning and have taken so much from your content. Please do an episode on Alopecia, in particular Alopecia Areata. The link between the autoimmune disease & the gut microbiome in particular fascinates me and I’ve been trying for years now to alter gut microbiome to see if I can send mine into remission. You thank us all for our interest in science, but I just want to thank you, for your interest in science, as without it, I speak for a lot of people in saying we’d be incredibly less informed if you hadn’t started your podcast. I sincerely mean that. Keep it up!

@venomwi844 2 місяці тому

I am a 13yr old and l am exceptionally grateful for the value that you provide in these kinds of long form videos😊

@haakoncj6887 2 місяці тому

Im 12 and even more grateful

@dakshpithadia 2 місяці тому

i am still in my mom's stomach and I am even more grateful@@haakoncj6887

@teamhop 2 місяці тому

Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.

@sakjdh 2 місяці тому

Iam 8 and I think this content is fantastic 🎉

@fasmaestro4155 2 місяці тому

I’m 3 and this information is phenomenal I’m so grateful too 🙏🏼

@SharingIdeology 2 місяці тому

Who's up early to listen to the Huberman!? 🧠 Growth time baby

@deep_fried_analysis 2 місяці тому

Morning, cup of coffee, winding up with Huberman ❤‍🔥

@SharingIdeology 2 місяці тому

Hope that cup of coffee is at least an hour after waking! 😝

@curiousc9259 2 місяці тому

Up here before work with coffee in hand! 😊

@donniet685 2 місяці тому

It drops in the early afternoon here.

@smilebot484 2 місяці тому

get your sleep!

@keithhoward7882 2 місяці тому

This episode caused several segments of tear shedding from being enlightened, most pleasantly overwhelmed.

@teamhop 2 місяці тому

@gribincealorelia848 2 місяці тому

I am 16 years old now & I'm deeply passionate about neuroscience and my dream is to become a neuroscientist one day. Thank you for showing me the beauty of this career❤Amazing episode, by the way:)I'm currently reading "You are the placebo" by Joe Dispenza right now

@noel05 2 місяці тому

Great career choice! Proud of you! You got this 👍

@pixelswalashorts 2 місяці тому

Good❤

@MarvinImproves 2 місяці тому

Youre on the way to a bright future. If youre this passionate at such a young age and know what you want to do, youre ahead of 99,9% of people. Keep it up!

@teamhop 2 місяці тому

@marezapetrou4535 2 місяці тому

I have so many life experiences to prove this belief! I have always said and believed our life Is the placebo. I Have used this to achieve the impossible in diagnosis,health,and life on general. So grateful scientists are catching up to this and giving alchemy recognition.❤

@kristinawiese84 2 місяці тому

Incredible episode. Blown away by how our brains work! Now, I'm excited to share and discuss all these amazing facts with my kids. Thanks for such a great listen, you're the absolute BEST 🙏

@cathygamble8609 2 місяці тому

Greetings! German teacher with MS here. I love your content, and I'm able to use so much of your teaching into professional development sessions for teachers. My last presentation integrated your research /analysis of neuroplasticity and mindset effects. Life-changing information for students and teachers alike, and I always direct my audience to you and Dr. Crum. You mentioned you had never seen The Matrix. Um... You absolutely have to see this movie -- for a lot of reasons -- but its dive into mindset effects goes along with everything you've been saying. "The mind makes it real" is one of my favorite moments of the movie, and there are so many moments that speak to the power of the mind and of belief systems. It's worth a deep dive on its own. I promise. 💜

@courpsecollectioner 2 місяці тому

Russian teenager listening, I'm 15 and have been listening to your podcasts for more than a year now. You have changed my life forever! Episode with David Goggins made me read his book, and I will never be the same. Also, not to mention dosens of different themes and protocols. Huge thank you. I really appreciate the availability of your content in other countries ❤

@kdoggdracul 2 місяці тому

Oh, just finished the Alia Crum episode on belief effects! Perfect timing! ❤ Thank you for everything!

@teamhop 2 місяці тому

@moatasim7 2 місяці тому

Just last week I was thinking about requesting an episode on belief effects in the comments section and here we are ❤️

@amanjaveri5666 2 місяці тому

Huberman I just want to state the fact that your videos are so accessible that a 15 year old watches them since 1year. I even have a sorta note book just for the knowledge bestowed upon me by your videos. I would love to see an episode on skin health. P.S. just love the way your videos are consistent with the intro and the sound track.

@jessicabailey6654 2 місяці тому

Yay! I've been waiting for this topic, thanks 😊

@3liBrns 2 місяці тому

Thank you for all your content. Your work has motivated me to pursue my masters degree in neuroscience. I’ve always had a passion for learning the relationship between the brain and body, and didn’t understand what the field of that interest was termed as until I discovered this podcast. Thank you again Dr Hubberman. I appreciate you more than you know

@teamhop 2 місяці тому

@77777jetta 2 місяці тому

Hey Andrew!!! You are my Dopamine! I learn so much from your podcast! Thank you for sharing your knowledge! Keep up the great work! Thanks MJ 🏃‍♀️

@teamhop 2 місяці тому

@user-mq3kn5pw4j 2 місяці тому

Placebo is one of my favorite effects, thank you for making it more well-known today Andrew.

@njott1021 2 місяці тому

Excellent. This is the kind of content that made me fall in love with this podcast

@teamhop 2 місяці тому

@KL-ni9ju 2 місяці тому

Thanks for this week's episode!

@PyroGamie 2 місяці тому

My body has the expectation that this will be a good video 💯

@B1971F 2 місяці тому

I am EXCITED for this one Andrew! Been hoping you would unpack this for a while now. Perhaps you might have Bruce Lipton or Joe Dispenza on the podcast too? We cant spell belief without a lie in the middle and if we don't know the lies in our beliefs, we will always be vulnerable to manipulation by those who do. Thanks for being here, you are deeply appreciated.

@olgazavilohhina6854 2 місяці тому

¡Hola Profe! Such a fascinating and thought provoking topic. Thank You for all Your hard work and care for all of us

@mdashikahmed398 2 місяці тому

You are a true gem Andrew!!! Thank you for your great contents.

@brandaceoriginal 2 місяці тому

Great episode and very helpful information. TBH, what really caught my attention was the tail end of the podcast regarding Individual Variations and Genetics, more specifically the COMT gene/enzyme. Your explanation of COMT and how a variation of the gene, could explain why an individual may or may not react/respond to a placebo peaked my interest. Not only that, the COMT’s association with an individual’s personality and stress reactions are fascinating. A brief trip down the internet rabbit hole about COMT produced so much information and I definitely want to know more! Thx!

@diegovallejo5398 2 місяці тому

Thank you for all that you do, this podcast is one of the few things keeping me going ❤

@Joy-cc1sw 2 місяці тому

Dr Huberman is inspiration

@DocJon1 2 місяці тому

Wow , another brilliant and relevant topic !!! Thanks Andrew!

@PhilosophicalNonsense-wy9gy Місяць тому

I'm 14, I've been watching your podcasts since 13, thank you for giving these invaluable information for free, I have used many tools and received many positive benefits ❤

@justin.baer_ 2 місяці тому

Very powerful episode right there, thanks a lot!

@marioo.4742 Місяць тому

If you are here looking for information that’s actually based on factual science you’re in the right place. Ive been here since 500k subs and I’ve watched almost every episode. I am in a much stronger place and constantly helping others with some useful information that they can experiment with to create a more fulfilling life

@itsmarsyadig 2 місяці тому

Mr. Huberman, I can go on about what you’re teachings have done for me but to keep it simple… thank you, I really appreciate you.

@teamhop 2 місяці тому

@sambadi782 2 місяці тому

An episode on brain damage from you would be awesome. Concussions and how they affect people in general, from brutal sports like some martial arts, rugby to other cases where brain damage is common. A topic not often talked about

@Linda_Sci 2 місяці тому

I travelled to watch you in Brisbane, thank you for the event. I greatly enjoyed your stories and your humor. Thank you also for the notebook, a lovely addition.

@3liBrns 2 місяці тому

The episode I’ve been waiting for 🙌🏼

@scope73 2 місяці тому

Dr Andrew, with the back of my head bashed in I'm still waking up each day, I believe I live because of your directions. After 2 years I've improvement, I desire to reincarnate as your child. I can't imagine I life better than that! Thank you so much for all that you do for me and everybody else!😊

@almeidaalin3 2 місяці тому

Hey Huberman, I just wanted to express how much I love your videos. Since day one, I've been a fan and have watched every single episode. I've got a suggestion for a topic that I think would be super helpful and interesting for many of us: emotional stability. After all, it's something we all struggle with at times. Why do we feel all over the place sometimes, and more importantly, what can we do about it? It would be amazing to have a science-based view of it and methods to improve ourselves. Thank you for the awesome work, and I'm looking forward to whatever you've got coming up next." 🇧🇷❤

@telefonustaxonasi2261 2 місяці тому

I can say now that there is a dopamine circuit in my brain that activates every time you release a podcast 😅😂

@besmart2350 2 місяці тому

UKposts plays with our dopamine system pretty well. They make us addicted

@in2097 2 місяці тому

Really was waiting for this! Thank you!

@belatortspota 2 місяці тому

Andrew ❤ I just found your podcast and I love it!!! I now know more vocabulary in english and I thank you for that❤

@222littlecat 2 місяці тому

Already love this episode just looking at the topic !!❤

@sebato_art 2 місяці тому

Hey Andrew Huberman, from my 4 grandparents, 2 had diabetes and one had the most awful illness i have seen, parkinson. I started two entrepeneurments in order to help people take care of themselves by working out, eating healthy and studying. I cannot be more grateful with you for all your work. I know we will meet some day and i hope you can participate in one of my talks, thank you again, greetings from Argentina. AGUANTE LA YERBA MATE Y ANDREW HUBERMAN!!

@aniketsingh1057 2 місяці тому

That is awesome Thank you so much for the episode may God bless you with lots of happiness ❤❤❤❤

@janelast5177 2 місяці тому

Thanks for sharing your knowledge and expertise I really learnt a lot from this podcast and will put it in practice when counselling patients

@bpetrova2818 2 місяці тому

Thank you so much Andrew Huberman!

@Kuk0san 2 місяці тому

Dr Huberman please do an episode on power dynamics. Thank you for the work you do!

@JORMUNGANDReyeS 2 місяці тому

This is the BEST Andrew! It is the acknowledgement of the Science of ENERGY before the Science of MATTER. Reality is created with ENERGY. We wield energy with our MIND. Energy is contagious, the more powerful energy, the contagion. Disconnecting from the cage of thoughts (law of man and its common "sense" - i.e. FEAR) FREES the mind to be in CONTROL instead of the AUTOMATION that's been conditioned.

@philliponfitness 2 місяці тому

oh man this one was so informative always wondered about how this actually works.

@jeannineluke 2 місяці тому

I believe I’m going to love this episode ❤️

@_IvanGrozny 2 місяці тому

You've got all ropes in the world, Andrew :) Thank you for not flying away.

@pguetan 2 місяці тому

Great content as always Andrew! I would love to see how placebo is related to cognitive biases pertaining to behavior and decision-making. Much love! 🔥💪

@newday2637 2 місяці тому

Great study, I have always been interested in the effects of placebos . The power of our mind and beliefs is incredible. It was very interesting the effect smelling food can have on hunger and releasing insulin. It made me wonder if watching food shows or tutorials, can have a similar effect.

@david.solar1 2 місяці тому

Dr Huberman, thank you very much for your work!! Would you please do an episode on hyperhidrosis? Many people are struggling with it without not many people knowing about it, thanks!🙏

@zahrakarimi7818 2 місяці тому

Great as always! Thank you🙌

@mattbarcello667 2 місяці тому

I can't wait to hear this one! I hope he goes over things like reiki and acupuncture as an example of placebo effects

@PaliCanon250 2 місяці тому

This is one of the times when Dr. Huberman is as excited as Carl Sagan always was when he talked about the cosmos, and I can see why!

@rororoyourboat 2 місяці тому

Dr rly went off on this ep. I love it sm

@nahidsafavi2925 2 місяці тому

Hi Doctor , I have been listening to your podcasts . Thank you so much all the knowledges that you transfer to all of us. Is there anyway we can have a podcast on narcissistic behavior please.

@user-py1iz1lv3x Місяць тому

This was very timely for me. I just stopped a medication for eczema (Dupixent) and I was ‘expecting’ a rebound at week ten. I just told myself this was likely. I tried to not think that way but I really felt it inside and couldn’t stop thinking about it. Sure enough I had a major eczema flare right at week ten! Your podcast really helped me realize the power of these thoughts and now I’m going to try to harness my mind to expect healing. I wish I could get saline needles to inject every two weeks. I bet my body would think it was Dupixent!!!

@jennyrock6185 2 місяці тому

Dr. Huberman, I'm a huge fan, and send everyone I know to your podcast. Thank you for all you do for the planet! Unrelated to this specific episode, PLEASE have a guest who is a Certified Rolfer (Structural Integration). You've mentioned fascia before, and many other things that relate to results from Rolfing, but without directly discussing it. It would be wonderful to have more on this topic. Thank you!

@johnedelmann6711 2 місяці тому

This is what I was waiting for!

@thethoughtfuelpod 2 місяці тому

Such a fascinating episode on how the mind can impact the body. Love it

@Kevin-db7tp Місяць тому

Thank you Andrew, you blew my mind just by talking about what the prefrontal cortex does.

@dameanvil 2 місяці тому

00:28 💊 Placebo, nocebo, and belief effects influence biology and psychology independently of physical or chemical properties of treatments. 01:23 🧠 Neural circuits in the brain modulate biological functions such as heart rate and blood pressure in response to expectations. 02:33 🩺 Placebo, nocebo, and belief effects can be harnessed as unique treatments for various diseases alongside traditional approaches. 07:29 🔬 Placebo effects are distinct from nocebo effects and belief effects, each with unique impacts on symptoms and performance. 09:26 🧠 The prefrontal cortex plays a key role in placebo, nocebo, and belief effects by modulating neural circuits that control physiological functions. 13:49 🧪 Placebo, nocebo, and belief effects rely on information and experiences shaping expectations, leading to physiological changes in the brain and body. 19:52 💡 Expectation strength varies across individuals and impacts the magnitude of placebo effects, highlighting the importance of placebo controls in clinical trials. 20:06 🧠 The placebo effect measures the expectation of a drug's effects in a trial, illustrating the impact of belief on outcomes. 21:30 🩸 Placebo effects show high specificity based on what individuals believe about a treatment, even impacting hormone levels. 23:31 💉 A placebo injection, even of saline, can lead to hormone changes based on prior knowledge or expectation of treatment. 31:48 🛎 Classical conditioning demonstrates how unrelated stimuli, like a bell, can trigger physiological responses like insulin release. 34:36 💊 Expectations about treatment quality, packaging, and color significantly impact the placebo effect. 39:15 🏥 The placebo effect is stronger with more invasive or complex treatments, showing the brain's association of complexity with larger outcomes. 40:37 🩸 Expectations, not just psychological, have real biological effects through specific brain circuitry. 41:06 🩸 Placebo effects have limitations, such as in cancer treatment, where they alleviate symptoms but do not shrink or eliminate tumors. 45:00 🎩 Placebo effects, while powerful, are specific and cannot completely eliminate conditions like asthma or cancer. 49:09 💡 Belief systems significantly shape how drugs, supplements, and behavioral protocols affect physiology and brain function. 53:01 🧠 Placebo effects scale with the degree of expectation one has, influencing outcomes even with the same dosage of a substance. 57:01 🍔 Beliefs about the calorie content and indulgence of food impact hormonal responses, affecting feelings of satiety and hunger regulation. 01:01:02 🏋‍♂ Beliefs and mindsets can also impact exercise outcomes, suggesting a significant interplay between psychology and physiology. 01:02:39 🏥 Simply believing that daily activities, like work, mimic exercise can lead to improvements in health metrics such as blood pressure and body weight. 01:05:23 🧠 While thoughts from the prefrontal cortex may not directly impact muscle growth, they can affect basic bodily functions like stress response through neural pathways. 01:06:06 🐀 A study on rats demonstrates a pathway from the prefrontal cortex to the hypothalamus, controlling stress responses, which has implications for understanding psychosomatic effects in humans. 01:10:06 💡 The placebo effect, influenced by genetics like the CT Gene, varies among individuals, showing different levels of response to placebo conditions. 01:12:21 🧬 Genetic variations, such as the CT Gene, correlate with differences in placebo response, indicating a biological basis for individual susceptibility to the placebo effect.

@denachubbic9494 2 місяці тому

Thank you

@german9864 2 місяці тому

Thank you very much man, you ve improve my life style

@user-lv7cz7wp6o 2 місяці тому

Can you make an episode on genetics, how it works and what we can do to change what we inherit ? By the way I don’t miss an episode and I thank you for sharing your knowledge free of cost..otherwise I could not have access to this information. Thank you again

@Anita-wh4vr 2 місяці тому

Interesting as always. Thank you so much ☺️! As I suffer quite a lot of slow COMT (it’s getting worse with high estrogen during perimenopause as the enzyme breaks down also estrogen and histamine to some extent), I should take advantage of the fact that I am genetically predisposed to have a stronger placebo effect ❣️❣️❣️

@awaiskhan5536 Місяць тому

I have written word by word of what he says, constituting about 5792 words on MS WORD. It will help me in my medical journey, Thank you Dr. Andrew it was great listening to you as you simplified placebo effect for me. Long live hero!!

@leta8796 2 місяці тому

Hey Andrew Huberman, I'd love to see the neuroscientist and memory expert, Professor *Christine Ann Denny*. Her lab has pioneered a method of being able to turn memories off and on! Mindboggling. I'm obsessed with studying Memory engrams (memory traces). They are after all the building blocks, the units of meaning we give everything. According to my memory, Huberman, your channel is the one I watch most. You helped me change my routines/ life.

@Giovanni-zj8vs 2 місяці тому

Hey Andrew, I’m immensely grateful and thankful for every piece of content you’ve created. Any chance you’ve thought about a video related to sports betting and gambling; how it affects the developing brain, human mindset and how both negatively impact our mental and emotional health “blindly” in adolescents and adults? I feel there are major placebo implications related to this topic as well and am curious as to what science based research has to say regarding gambling addictions, the view of rapid monetary rewards and hits to our self-esteem. Especially with both fields becoming so widespread legally and easily accessible. Thank you a ton, you are the man

@KeredB94 2 місяці тому

I feel like an episode doing a deep dive on the prefrontal cortex would be amazing.

@austinkuipers6087 2 місяці тому

Belief as a means to conduct ones own neurology into performing feats which used to be attributed to mass-parallelized imaginary friends is freakin awesome.

@kam8837 2 місяці тому

Thank you Dr. Huberman for giving us the precious knowledge.❤ Please make an episode on bad breath/halitosis and how to get rid of it 😢

@mariaguzman9516 2 місяці тому

I believe there's an oral episode

@keshab97 2 місяці тому

Thank you for providing us all these usefull information and i think its a high time that you should write a book including all these information it will be a bestselller for sure.

@Abbas-fl3bw 2 місяці тому

Hi Dr Huberman, I'm 2 months old and your podcasts have been an invaluable resource in my journey to further my intellectual capacities. I cannot yet walk, let alone crawl, but I am already making great strides towards my future!

@kathleenward6268 2 місяці тому

That's funny!

@GajduS12 2 місяці тому

Hey Andrew, just a spitballing but would love to see you talk a little about neurodegenerative progress or diseases. As a person with such disease it would clear so much unknown and questions, that not only me, but a lot of other people touched by such diseases have. Love the incentive of sharing such knowledge in these podcasts btw, keep doing you :)

@raindropsonroses7018 2 місяці тому

I work as a medical interpreter in Australia. Years ago I had a patient who came to ED due to heart issues and high blood pressure. He was going to undergo an emergency open heart surgery. He was so nervous about dying on surgery table that his blood pressure couldn’t be controlled by medicine through the drip very 15 minutes. His daughters came to see him before the surgery, they told him to pray as their family believes in God. The two daughters held his hands and prayed for a few minutes, his blood pressure came down and stabilised. Today’s podcast clearly explained why and how belief can have placebo effect.

@teamhop 2 місяці тому

@DisnStukKk 2 місяці тому

Thank you for a surprisingly interesting episode! You are an n of one in teaching science. Thank you so much!! Please consider doing an episode on fascia

@TimelessHealercom 23 дні тому

Spectacular🤩🤩😍Dr. Huberman! The placebo effect has always served me so well in my long medical career… you just described with great precision the mechanisms involved… blew my mind, man! Thank you so so much🙏🏽🪷💥

@hibabelimi5328 2 місяці тому

Very interesting topic. Short story when I was a resident one (hospitalized)patient told me that only one particular IV injection could release her pain, nothing was mentioned in her therapeutic sheet, when I asked my colleague what was the drog he gave her: he told me 10 ml of isotonic saline!

@JORMUNGANDReyeS 2 місяці тому

Yes, the MIND rules ALL for REALZ 🙌

@oscartix2539 2 місяці тому

Dr Huberman, thank you for all you do!! Could you please consider doing an episode on the effects of dairy consumption including both the effects of lactose and whey protein? There seems to be a lot of debate over the topic with dairy's effect on acne and much else.

@dimitrisorokin25 2 місяці тому

Been waiting for this since the episode with dr. Crum

@zeynepconker3795 2 місяці тому

Amazing information as usual Dr Huberman. Thank you. Could you please do a podcast on visual disturbances like migraines with aura and seeing things, faces etc, like a Picasso paint.

@amirhosseinrashidi4597 2 місяці тому

Im watching your videos from the start and had a peek at this one since it just released. I must say you look different! Best of luck to you

@alexd.alessandro5419 2 місяці тому

Thanks for this, for the last year I've been meaning to ask you for a program regarding Placebo effects 😅.

@jopo7996 2 місяці тому

I'm not sure I believe in the placebo effect. I don't have time to watch this right now, but I feel better just knowing Dr. Huberman uploaded this.

@sew1what 2 місяці тому

😂

@LiveContentCreator 2 місяці тому

Same here maybe listen on the commute to work or walking on the treadmill! Let's listen together, lol

@debrapopowich885 2 місяці тому

You mentioned previously the topic of Cold Sores and doing an episode. (I think involving the trigeminal nerve.) Hope this topic is still on your list. Thank you for all the research you put in.

@joshbozz 2 місяці тому

Thank you so much for the depth and very palatable way you present all your information, truly a pleasure. In regards to this placebo subject, maybe a good guest would be Dr. Bruce Lipton and his research into Epigenetics? Best

@sohaibkhan8652 2 місяці тому

Really appreciate the amount of knowledge you are bringing to everyday people. With Ramadan coming can you maybe talk about fasting aspect and it's effect in a future episode

@stefanmarinkovic2501 2 місяці тому

Andrew, can you please consider making episodes with Dr. Joe Dispenza. I believe it would be interesting to hear you two discussing the topic of neurobiology, neuroplasticity, placebo, nocebo, etc. For me personally, Doctor Joe had a huge impact in the field of neuroplasticity and self work. I believe there are more people who share the same thoughts. Thank you for your effort and all that you are doing for the world! 🙏🏻🙏🏻🙏🏻

@lionmr8792 27 днів тому

Learnt alot from this video, thank you dr Andrew

@kkatecollins 2 місяці тому

Thank you for away sharing amazing science. Your voice is music to my ears. The best part- I am able to stare at you for hours in awe, and of course learning and soaking up the knowledge you share. I loved this podcast🎉🎉🎉 Also, Let’s get married and start a family! ❤❤

@Arayav 2 місяці тому

Dr. Huberman, I would be interested to hear if there might be a salient correlation between individuals who are more susceptible to placebo effects and those who are more receptive to self-hypnosis. Thanks and keep up the good work (from an aspiring student of neuroscience).

@jaluban 2 місяці тому

Great as always. ... Idea for a podcast: Interview Mary-Frances O'Connor at U of Arizona, a specialist on the physiology and psychology of grief.

@stormfromthesea 2 місяці тому

Kind of off-topic to this video, but I was wondering if you could please cover the topic of consuming Lichen and it's potential benefits. Thank you for all that you share. My husband and I love your podcast!

@gray1232 2 місяці тому

Hi Andrew, thank you for your very informative episodes. Can you do an episode on declining numerical skills with age, how can it be stopped, and how numberical/ mathematical skills can be improved in adults. I have had above average numerical skills in school but with age I am experiencing difficulties in performing simple mathematical calculations mentally.